1997
DOI: 10.1076/ceyr.16.12.1202.5034
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Chemokines in acute anterior uveitis

Abstract: This is the first study of chemokine concentrations in the aqueous humor of patients with acute anterior uveitis. The concentration of chemokines: IL-8, IP-10, MCP-1, RANTES and MIP-1 beta were significantly increased during the active stages of AU, and correlated with the clinical severity of the disease. These chemoattractant cytokines probably play a critical role in leucocyte recruitment in acute AU.

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Cited by 104 publications
(82 citation statements)
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“…MCP-1 is an important mediator of monocyte infiltration (Gu et al, 1999) and is shown to be over-expressed in human eyes during acute anterior uveitis (Verma et al, 1997) as well as in the rat EIU model (de Vos et al, 1994). The results of this study show that captopril successfully down-regulates MCP-1 levels in anterior chamber, thus showing its anti-inflammatory properties also by affecting monocyte recruitment in EIU.…”
Section: Discussionmentioning
confidence: 99%
“…MCP-1 is an important mediator of monocyte infiltration (Gu et al, 1999) and is shown to be over-expressed in human eyes during acute anterior uveitis (Verma et al, 1997) as well as in the rat EIU model (de Vos et al, 1994). The results of this study show that captopril successfully down-regulates MCP-1 levels in anterior chamber, thus showing its anti-inflammatory properties also by affecting monocyte recruitment in EIU.…”
Section: Discussionmentioning
confidence: 99%
“…94 In addition to being found in the aqueous humor of patients with anterior uveitis, increased serum IL-8 levels have been associated with increased disease activity in idiopathic intermediate uveitis. 79,95 In humans, IL-4 has only been detected in low levels and at levels not significantly different from controls in the aqueous humor and serum of patients with idiopathic uveitis. 86 91 A recent study also showed that there were no significant differences in aqueous humor IL-4 levels between anterior uveitis, panuveitis and control groups, but that IL-5 was significantly not detected in the panuveitis groups with idiopathic uveitis as compared to controls and those with idiopathic anterior uveitis.…”
Section: Cytokines and Chemokines In Patients With Uveitismentioning
confidence: 99%
“…77 Fractalkine upregulation prior to disease onset in experimental autoimmune uveitis has also been demonstrated. 78 As yet, only the chemokines IL-8, MIP-1β and MCP-1 have been investigated in the aqueous humor in patients with acute anterior uveitis, 13,79 and CCL2 (MCP-1), CCL5 (RANTES), CCL11 (Eotaxin), TGF-β2 and CXCL12 (SDF-1) have been investigated in patients with anterior uveitis. 13 …”
Section: Chemokines In Experimental Uveitismentioning
confidence: 99%
“…Increased chemokine production is correlated to leukocyte recruitment in the eye. In a recent study of patients, IL-8, inflammatory protein-10 (IP-10), monocyte chemoattractant protein-1 (MCP-1), RANTES, and macrophage inflammatory protein-1␣ (MIP-1␣) were significantly increased in the aqueous humor during the active stages of anterior uveitis (16). Chemokines are also associated with the neuroinflammatory processes in experimental allergic encephalomyelitis (EAE), a mouse model for multiple sclerosis (MS) (7).…”
mentioning
confidence: 99%