Chemokines—What Is Their Role in Colorectal Cancer?

Pączek, Sara; Łukaszewicz-Zając, Marta

doi:10.1177/1073274820903384

Cited by 18 publications

(16 citation statements)

References 92 publications

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“…19,[30][31][32][33] Growthregulated oncogene (GRO) has three different genetic variants: CXCL1 (GRO-α), CXCL2 (GRO-β) and CXCL3 (GRO-γ) which interact with CXCR2. [34][35][36][37][38][39][40][41][42] Furthermore, CXCL8, known as interleukin-8 (IL-8), is able to activate both CXCR2 and CXCR1 and has pro-tumoral capacity via the activation of pro-tumoral neutrophils and stimulation of angiogenesis. 40,42 However, only CXCR2 possesses the ability to promote neoangiogenesis, while CXCL1 binds CXCR2 with higher affinity.…”

Section: Chemokines In Cancer Progressionmentioning

confidence: 99%

<p>The Significance of CXCL1 and CXCL8 as Well as Their Specific Receptors in Colorectal Cancer</p>

Łukaszewicz-Zając¹,

Pączek²,

Mroczko³

et al. 2020

CMAR

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Every year, almost 2 million people develop colorectal cancer (CRC), which makes it the fourth most common malignancy worldwide. It is also estimated that approximately 48% of CRC patients will die from the disease. Thus, noninvasive and accurate methods for early detection and prevention of CRC are sorely needed. It is suggested that C-X-C motif ligand 1 (CXCL1) and C-X-C motif ligand 8 (CXCL8) as well as their cognate receptors can mediate tumor growth, proliferation, survival, neoangiogenesis and metastasis of malignant cells, including CRC. However, little is known about the clinical significance of these proteins as potential biomarkers for CRC. Therefore, in our review, we performed a comprehensive literature search using the PubMed database to identify original articles that investigated whether CXCL1 and CXCL8 and their receptors play a role in CRC pathogenesis. In summary, our review highlighted the potential significance of CXCL1/CXCR2 and CXCL8/CXCR1,-2 in the diagnosis and progression of CRC as well as indicated their potential therapeutic significance. However, given the non-specific nature of analyzed chemokines and a small number of studies concerning the assessment of blood concentration of these proteins in CRC patients, investigations need to be continued in the future before selected chemokines could be established as biomarkers for CRC.

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Section: Chemokines In Cancer Progressionmentioning

confidence: 99%

<p>The Significance of CXCL1 and CXCL8 as Well as Their Specific Receptors in Colorectal Cancer</p>

Łukaszewicz-Zając¹,

Pączek²,

Mroczko³

et al. 2020

CMAR

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“…Furthermore, the infiltration of various immune cells, such as tumorinfiltrating leukocytes (TILs), various cytokines and tissue remodeling factors, has also been associated with cancer-related inflammation. Our previous original studies as well as some clinical investigations of other authors prove that selected circulating inflammatory mediators such as cytokines, including chemokines and hematopoietic growth factors (HGFs), specific inflammatory proteins such as C-reactive protein (CRP) and various matrix metalloproteinases, in particular gelatinases (MMP-2, MMP-9) and their tissue inhibitors (TIMP-1, TIMP-2), could be involved in the tumor development, proliferation, migration and angiogenesis of cancer cells (Figure 1), and may be considered potential candidates for novel biochemical markers for CRC (Table 1) [18][19][20][21][22][23][24][25][26][27][28]. Hematopoietic cytokines (HCs), also known as hematopoietic growth factors (HGFs), are small proteins that induce the differentiation and proliferation of hematopoietic progenitor cells.…”

Section: Colorectal Cancermentioning

confidence: 99%

Circulating Biomarkers of Colorectal Cancer (CRC)—Their Utility in Diagnosis and Prognosis

Łukaszewicz-Zając

2021

JCM

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The global burden of colorectal cancer (CRC) is expected to increase, with 2.2 million new cases and 1.1 million annual deaths by 2030. Therefore, the establishment of novel biomarkers useful in the early diagnosis of CRC is of utmost importance. A number of publications have documented the significance of the overexpression of several specific proteins, such as inflammatory mediators, in CRC progression. However, little is known about the potential utility of these proteins as circulating blood tumor biomarkers of CRC. Therefore, in the present review we report the results of our previous original studies as well as the findings of other authors who investigated whether inflammatory mediators might be used as novel biomarkers in the diagnosis and prognosis of CRC. Our study revealed that among all of the tested proteins, serum M-CSF, CXCL-8, IL-6 and TIMP-1 have the greatest value in the diagnosis and progression of CRC. Serum TIMP-1 is useful in differentiating between CRC and colorectal adenomas, whereas M-CSF and CRP are independent prognostic factors for the survival of patients with CRC. This review confirms the promising significance of these proteins as circulating biomarkers for CRC. However, due to their non-specific nature, further validation of their sensitivity and specificity is required.

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“…There are over twenty chemokine receptors which are seven-transmembrane, G protein-coupled receptors [ 13 ]. One chemokine can be related to many receptors, whereas a specific receptor may be activated by several ligands [ 14 ]. Chemokine receptors participate both in physiological processes and in cancers, cardiovascular diseases, or infections [ 13 ].…”

Section: Gastric Cancermentioning

confidence: 99%

“…Controlled inflammation is an important and beneficial process since it can, for example, promote wound healing or defend the body against pathogens. Moreover, chemokines are also crucial to processes such as atherosclerosis, autoimmune diseases, or HIV infection [ 14 ]. They play an important role in autoimmune diseases such as rheumatoid arthritis.…”

Section: Gastric Cancermentioning

confidence: 99%

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The Role of Chemokines in the Development of Gastric Cancer—Diagnostic and Therapeutic Implications

Pawluczuk

Łukaszewicz-Zając

Mroczko

2020

IJMS

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Gastric cancer (GC) is the fifth most common cancer worldwide and the second leading cause of cancer-related death. GC is usually diagnosed at an advanced stage due to late presentation of symptoms. Therefore, there is a need for establishing more sensitive and specific markers useful in early detection of the disease when a cancer is asymptomatic to improve the diagnostic and clinical decision-making process. Some researchers suggest that chemokines and their specific receptors play an important role in GC initiation and progression via promotion of angiogenesis, tumor transformation, invasion, survival and metastasis as well as protection from host response and inter-cell communication. Chemokines are small proteins produced by various cells such as endothelial cells, fibroblasts, leukocytes, and epithelial and tumor cells. According to our knowledge, the significance of chemokines and their specific receptors in diagnosing GC and evaluating its progression has not been fully elucidated. The present article offers a review of current knowledge on general characteristics of chemokines, specific receptors and their role in GC pathogenesis as well as their potential usefulness as novel biomarkers for GC.

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Chemokines—What Is Their Role in Colorectal Cancer?

Cited by 18 publications

References 92 publications

<p>The Significance of CXCL1 and CXCL8 as Well as Their Specific Receptors in Colorectal Cancer</p>

<p>The Significance of CXCL1 and CXCL8 as Well as Their Specific Receptors in Colorectal Cancer</p>

Circulating Biomarkers of Colorectal Cancer (CRC)—Their Utility in Diagnosis and Prognosis

The Role of Chemokines in the Development of Gastric Cancer—Diagnostic and Therapeutic Implications

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