Chemometric analysis of the seasonal variation in the essential oil composition and antioxidant activity of a new geraniol chemotype of Lippia alba (Mill.) N.E.Br. ex Britton &amp; P. Wilson from the Brazilian Amazon

Barros, Luana de Sousa Peixoto; Cruz, Ellen de Nazaré Santos da; Guimarães, Bruna de Araújo; Setzer, William N.; Mourão, Rosa Helena Veras; Silva, Joyce Kelly do Rosário da; Costa, Jaqueline Macedo; Figueiredo, Pablo Luis B.

doi:10.1016/j.bse.2022.104503

Cited by 18 publications

(5 citation statements)

References 21 publications

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“…These findings corroborate the idea that seasonal variation can cause the variation of the composition of volatile oil and affect the oil yield [38]. Several factors can lead to the variation in the essential oil content and its composition, such as light, temperature, reproductive stage, season, and the growing conditions which is in accordance with results reported before [26,39,40]. From our findings, we have deduced that seasonal variation can cause…”

Section: Gc/ms Analysissupporting

confidence: 92%

The impact of seasonal variation on the composition of the volatile oil of Polyalthia suberosa (Roxb.) Thwaites leaves and evaluation of its acetylcholinesterase inhibitory activity

Mahmoud,

Ayoub,

Eldahshan

et al. 2024

BMC Complement Med Ther

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Background Polyalthia suberosa (Roxb.) Thwaites (Annonaceae) is a medicinal plant that has been reported for its various pharmacological potentials, such as its anti-inflammatory, analgesic, antioxidant, and neuropharmacological activities. This study aimed to analyze the leaf essential oils of P. suberosa (PSLO) collected in different seasons, to evaluate the acetylcholinesterase inhibitory activity, and to corroborate the obtained results via in-silico molecular docking studies. Methods The leaf essential oils of P. suberosa collected in different seasons were analyzed separately by GC/MS. The acetylcholinesterase inhibitory activity of the leaves oil was assessed via colorimetric assay. In-silico molecular docking studies were elucidated by virtual docking of the main compounds identified in P. suberosa leaf essential oil to the active sites in human acetylcholinesterase crystal structure. Results A total of 125 compounds were identified where D-limonene (0.07 − 24.7%), α-copaene (2.25 − 15.49%), E-β-caryophyllene (5.17 − 14.42%), 24-noroleana-3,12-diene (12.92%), β-pinene (0.14 − 8.59%), and α-humulene (2.49–6.9%) were the most abundant components. Results showed a noteworthy influence of the collection season on the chemical composition and yield of the volatile oils. The tested oil adequately inhibited acetylcholinesterase enzyme with an IC50 value of 91.94 µg/mL. Additionally, in-silico molecular docking unveiled that palmitic acid, phytol, p-cymene, and caryophyllene oxide demonstrated the highest fitting scores within the active sites of human acetylcholinesterase enzyme. Conclusions From these findings, it is concluded that P. suberosa leaf oil should be evaluated as a food supplement for enhancing memory.

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Section: Gc/ms Analysissupporting

confidence: 92%

The impact of seasonal variation on the composition of the volatile oil of Polyalthia suberosa (Roxb.) Thwaites leaves and evaluation of its acetylcholinesterase inhibitory activity

Mahmoud,

Ayoub,

Eldahshan

et al. 2024

BMC Complement Med Ther

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“…The essential oil was dehydrated by centrifugation (5 min, 3,000 rpm) with anhydrous Na 2 SO 4 and repeated centrifugation. The percent yield of essential oil expressed in percent (v/w) and calculated from humidity-free biomass through the relationship between oil volume, mass plant sample, and humidity calculated as follows 100% × volume essential oil/mass dry leaves ( Barros et al, 2022 ).…”

Section: Methodsmentioning

confidence: 99%

Exploring the impact of seasonal variations on the chemical composition, antinociceptive, and anti-inflammatory properties of Pogostemon heyneanus Benth. essential oil

Santos,

Jerônimo,

Ribeiro

et al. 2024

Front. Pharmacol.

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Background:Pogostemon heyneanus leaves infusions are relevant in ethnopharmacology for treating colds, coughs, headaches, and asthma.Purpose: The essential oil chemical composition of a Pogostemon heyneanus specimen was monthly monitored from October 2021 to July 2022 to evaluate the climatic influences on its yield and chemical composition and antinociceptive, andanti-inflammatory properties.Methods: The leaves, collected monthly over a 10-month period, were submitted to hydrodistillation. The oils obtained were analyzed by gas chromatography coupled to a mass spectrometer and gas chromatography coupled to flame ionization detector. The P. heyneanus essential oil (PhEO) was tested in vivo to evaluate its peripheral analgesic actions through the abdominal writhing test induced by acetic acid, and peripheral analgesia by tail immersion. Neurogenic and inflammatory pain were evaluated by formalin test, and acute oral toxicity of the oil was also verified.Results: PhEO presented 27 chemical constituents with the highest predominance of patchoulol (43.6%–76.9%), α-bulnesene (0.2%–12.7%), α-guaiene (0.4%–8.9%), seychellene (3.8%–5.1%) and pogostol (0.0%–8.2%). The climatic parameters insolation, humidity, rainfall, and temperature did not influence the essential oil yield or the main chemical constituents, except for pogostol, which presented a strong (r = 0.73) and statistically significant (p < 0.05) correlation with temperature. PhEO did not display toxicity at the maximum 300 mg/kg dosage. The oil showed low peripheral and central analgesic action at 100 mg/kg, while in the neurogenic and inflammatory pain inhibition tests, no actions related to PhEO were observed. In the carrageenan-induced peritonitis test, PhEO did not reduce the migration of leukocytes to the peritoneal cavity compared to the control group.Conclusion:Pogostemon heyneanus is a resistant plant to seasonal influences and a source of patchoulol. Despite ethnopharmacological indications, no in-vivo biological activities such as neurogenic or inflammatory pain were identified in the present work. So, the low influence of the climatic parameters on chemical composition can infer that the low pharmacological activity is also not subject to climatic variations, that is, it does not change due to the climate.

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“…The dry period in the region where the plant occurs comprised the months from August to February, with an average precipitation of 253.7 ± 58.4 mm, and the rainy period from March to May, with an average precipitation of 472.5 ± 60.2 mm (Figure 1). In previous work, in the seasonal study of the essential oil composition of Lippia alba, the dry period occurred from August to February, and the rainy period from March to May [16]. The climate in the Brazilian Amazon is represented only by the dry and rainy seasons.…”

Section: Seasonal Effect On Oil Yieldsmentioning

confidence: 99%

Seasonal Influence on Volatile Composition of Psidium friedrichsthalianum Leaves, Sampled in the Brazilian Amazon

et al. 2023

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Psidium friedrichsthalianum (Myrtaceae) is a small tree with antioxidant activity in its fruits and antimicrobial activity in its leaves and thin branches. The present study analyzed the seasonal variability in the yield and essential oil composition of a P. friedrichsthalianum population in Belém, Brazil. Essential oils were obtained by hydrodistillation and analyzed by gas chromatography (GC) coupled to mass spectrometer (MS) and flame ionization detector (FID). Chemometric analyses were carried out to verify the climatic influence on the production and composition of the essential oil. The average oil yield in the dry season (August–February) was 0.5 ± 0.0%, and in the rainy season (March–May), it was 0.8 ± 0.0%, with statistical differentiation. There was a moderate correlation between oil yield and the collection area’s relative humidity (r = 0.63). The PCA and HCA analyses did not show differentiation between the P. friedrichsthalianum oil samples during the dry and rainy seasons. However, the class of monoterpene hydrocarbons presented a negative correlation with temperature (r = −0.81) and humidity (−0.80) of the sampled area. In the PCA and HCA studies, the samples were classified into three groups: Group I (leaf oils) was characterized by a higher content of α-pinene (6.3–18.0%), β-elemene (9.9–14.8%), caryophyllene oxide (4.3–16.3%), and β-pinene (4.8–13.4%). Group II (leaf oils) was defined by a higher content of selin-11-en-4-α-ol (4.6–15.6%), β-elemene (9.9–14.8%), α-pinene (6.3–18.0%), and E-caryophyllene (3.1–8.7%). Group III (fruits volatile concentrate) was characterized by a higher content of α-pinene (17.6%), α-terpineol (13.7%), and selin-11-en-4-α-ol (10.0%). There was significant seasonal variability in P. friedrichsthalianum, whose responses are directly linked to abiotic factors such as precipitation, insolation, humidity, and temperature.

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Chemometric analysis of the seasonal variation in the essential oil composition and antioxidant activity of a new geraniol chemotype of Lippia alba (Mill.) N.E.Br. ex Britton & P. Wilson from the Brazilian Amazon

Cited by 18 publications

References 21 publications

The impact of seasonal variation on the composition of the volatile oil of Polyalthia suberosa (Roxb.) Thwaites leaves and evaluation of its acetylcholinesterase inhibitory activity

The impact of seasonal variation on the composition of the volatile oil of Polyalthia suberosa (Roxb.) Thwaites leaves and evaluation of its acetylcholinesterase inhibitory activity

Exploring the impact of seasonal variations on the chemical composition, antinociceptive, and anti-inflammatory properties of Pogostemon heyneanus Benth. essential oil

Seasonal Influence on Volatile Composition of Psidium friedrichsthalianum Leaves, Sampled in the Brazilian Amazon

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