Chemometric tools improving the determination of anti-inflammatory and antiepileptic drugs in river and wastewater by solid-phase microextraction and liquid chromatography diode array detection

García, Miguel de Cara; Cañada-Cañada, Florentina; Culzoni, María J.; Vera‐Candioti, Luciana; Siano, Gabriel G.; Goicoechea, Héctor C.; Galera, M. Martı́nez

doi:10.1016/j.chroma.2009.05.073

Cited by 56 publications

(25 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Firstly, eight tetracycline antibiotics were determined in effluent wastewater, solving matrix effects and exploiting the second-order advantage [59,60]. Afterward, the determination of anti-inflammatory and antiepileptic drugs in river and wastewater by solid-phase microextraction and liquid chromatography diode-array detection with MCR-ALS was presented [61]. The following study included 11 pharmaceuticals which were quantitated in river water by column switching of large sample volumes and HPLC-DAD, modeling with MCR-ALS [62].…”

Section: Uv Spectroscopy With Diode-array Detectionmentioning

confidence: 99%

“…Recently, in our group the second-order algorithm MCR-ALS was applied in combination with standard addition calibration for the determination of drugs in environmental water samples by LC-DAD [61,62]. In a first work, eight pharmaceuticals were determined in wastewaters samples [59] containing compounds interfering with the analytes of interest with a variable effect between samples, in addition to matrix effect.…”

Section: Liquid Chromatographymentioning

confidence: 99%

“…The latter case was observed with different extraction techniques such as solid-phase extraction (SPE) [59,60,64] and solid-phase microextraction (SPME) [61]. These sample treatments are necessary to increase sensitivity of the analytical methods when analytes are present at ultratrace levels in the samples being analyzed.…”

Section: Standardizationmentioning

confidence: 99%

“…PDS was applied to correct the breakthrough effect observed for the most polar analytes after the SPE step in a method developed for the determination of eight tetracyclines in effluent wastewater samples by solid-phase extraction (SPE) and LC-DAD using MCR-ALS [60] and U-PLS/RBL [61] algorithms. The five first eluting compounds were partially lost during the pre-concentration step and this drawback was overcome by transferring sample signals obtained from standards prepared in pure solvent to signals after SPE and then, unknown samples were predicted with models built with the former.…”

Section: Standardizationmentioning

confidence: 99%

“…PDS combined with MCR-ALS was also applied in the determination of seven non-steroidal anti-inflammatory drugs and one anticonvulsant in river and wastewater by SPME-LC-DAD [61].…”

Section: Standardizationmentioning

confidence: 99%

See 4 more Smart Citations

Chemometric strategies for enhancing the chromatographic methodologies with second-order data analysis of compounds when peaks are overlapped

Goicoechea

Culzoni

García

et al. 2011

Talanta

Self Cite

View full text Add to dashboard Cite

This overview covers the different chemometric strategies linked to chromatographic methodologies that have been used and presented in the recent literature to cope with problems related to incomplete separation, the presence of unexpected components in the sample, matrix effect and changes in the analytical signal due to pre-treatment of sample.Among the different chemometric strategies it focuses on pre-treatment of data to correct background and time shift of chromatographic peaks and the use of second-order algorithms to cope with overlapping peaks from analytes or from analytes and interferences in liquid chromatography coupled to diode array, fast-scanning fluorescence spectroscopy and mass spectrometry detectors.Finally the review presents the strategies used to deal with changes in the analytical response as result of matrix effect in liquid and gas chromatography, as well as the use of standardization strategies to correct modifications in the analytical signal as a consequence of sample pre-treatment in liquid chromatography.

show abstract

Section: Uv Spectroscopy With Diode-array Detectionmentioning

confidence: 99%

Section: Liquid Chromatographymentioning

confidence: 99%

Section: Standardizationmentioning

confidence: 99%

Section: Standardizationmentioning

confidence: 99%

“…PDS combined with MCR-ALS was also applied in the determination of seven non-steroidal anti-inflammatory drugs and one anticonvulsant in river and wastewater by SPME-LC-DAD [61].…”

Section: Standardizationmentioning

confidence: 99%

See 3 more Smart Citations

Chemometric strategies for enhancing the chromatographic methodologies with second-order data analysis of compounds when peaks are overlapped

Goicoechea

Culzoni

García

et al. 2011

Talanta

Self Cite

View full text Add to dashboard Cite

show abstract

Environmental Applications of Solid Phase Microextraction Techniques

Montesdeoca-Esponda

Torres-Padrón

Sosa‐Ferrera

et al. 2015

Analytical Separation Science

View full text Add to dashboard Cite

Miniaturization is a strategy employed in sample preparation that has gained much prominence in recent years due to the need to develop more efficient procedures that consume less solvent and time. The analysis of important families of contaminants, such as pesticides or polycyclic aromatic hydrocarbons ( PAH s), in liquid samples has traditionally been conducted using conventional techniques, such as liquid–liquid extraction ( LLE ) and solid‐phase extraction ( SPE ). Although SPE uses much less amount of solvent than LLE , the volume can still be significant, making both techniques expensive and environment‐unfriendly procedures. The miniaturization of sample preparation processes has led to a new generation of techniques with improved characteristics. Different solid‐phase microextraction ( SPME ) techniques, including fibers, stir bar sorptive extraction ( SBSE ) and thin‐film microextraction ( TFME ), and automated techniques, such as in‐tube solid‐phase microextraction ( IT ‐ SPME ), have allowed the determination of different families of contaminant compounds, including emerging compounds in complex environmental waters, such as seawater, groundwater, or superficial water. The emerging compounds are relatively unknown compounds that are not covered by the existing regulations; they are frequently detected in different environmental compartments in very low concentrations. For this reason, their analysis requires extraction, purification and preconcentration from the matrix and subsequent separation and detection systems that can measure these concentration levels. In this chapter, we review the most recent applications of microextraction techniques based on solid phase coupled to liquid chromatography ( LC ) for the determination of different emerging contaminants in several water environmental matrices.

show abstract

A novel microextraction by packed sorbent–gas chromatography procedure for the simultaneous analysis of antiepileptic drugs in human plasma and urine

Rani¹,

Malik

2012

J of Separation Science

View full text Add to dashboard Cite

A simple, accurate, and sensitive microextraction by packed sorbent-gas chromatography-mass spectrometry method has been developed for the simultaneous quantification of four antiepileptic drugs; oxcarbazepine, carbamazepine, phenytoin, and alprazolam in human plasma and urine as a tool for drug monitoring. Caffeine was used as internal standards for the electron ionization mode. An original pretreatment procedure on biological samples, based on microextraction in packed syringe using C(18) as packing material gave high extraction yields (69.92-99.38%), satisfactory precision (RSD < 4.7%) and good selectivity. Linearity was found in the 0.1-500 ng/mL range for these drugs with limits of detection (LODs) between 0.0018 and 0.0036 ng/mL. Therefore, the method has been found to be suitable for the therapeutic drug monitoring of patients treated with oxcarbazepine, carbamazepine, phenytoin, and alprazolam. After validation, the method was successfully applied to some plasma samples from patients undergoing therapy with one or more of these drugs. A comparison of the detection limit with similar methods indicates high sensitivity of the present method over the earlier reported methods. The present method is applied for the analysis of these drugs in the real urine and plasma samples of the epileptic patients.

show abstract

Chemometric tools improving the determination of anti-inflammatory and antiepileptic drugs in river and wastewater by solid-phase microextraction and liquid chromatography diode array detection

Cited by 56 publications

References 26 publications

Chemometric strategies for enhancing the chromatographic methodologies with second-order data analysis of compounds when peaks are overlapped

Chemometric strategies for enhancing the chromatographic methodologies with second-order data analysis of compounds when peaks are overlapped

Environmental Applications of Solid Phase Microextraction Techniques

A novel microextraction by packed sorbent–gas chromatography procedure for the simultaneous analysis of antiepileptic drugs in human plasma and urine

Contact Info

Product

Resources

About