Chemometrics-Assisted UV-Vis Spectrophotometry for Quality Control of Pharmaceuticals: A Review

Abstract

Spectroscopic method in the UV-Vis region is considered the most molecular spectrometric method for content determination of a single component. However, a lot of pharmaceutical dosage forms comprise two or more components which lead to peak overlapping. Moreover, in the chemical stability test, active pharmaceutical ingredient (API) was also found along with the degradation products, impurities, and adulterant compounds. UV-Vis spectroscopy is one of the methods of choice for the determination or quantification of a single component in pharmaceutical preparations. The pharmaceutical products typically contain two or more APIs having chromophoric agents capable of absorbing UV-Vis beams and the absorbance values are summative from the absorption of each UV-Vis active compound according to the additive nature of Lambert-Beer law. The main problem for the simultaneous determination of API along with impurities and the degradation products in pharmaceutical preparations is the presence of overlapping peaks of UV-Vis spectra. The chemometrics-assisted spectroscopy is one of the analytical efforts to solve these problems. This review highlighted the application of chemometrics in combination with UV-Vis spectroscopy for the assay of API, impurities, adulteration issues and degradation products present in pharmaceutical dosage forms.

Greening the waves: experimental and chemometric approaches in spectroscopic methods for organic pollutant determination in natural waters

“…However, several challenges need to be addressed to fully realize the potential of green spectroscopic methods in water quality analysis. 81–84…”

Regulating the Monomer Symmetry of Poly-Perylene-Diimides for Photocatalytic H2O2 Production

“…The effective use of clean energy and protection of the living environment are necessary guarantees for the sustainable coexistence of all species on the earth [3]. In the current research, photocatalysis technology using clean solar energy has aroused great attention [4,5]. Among various solar photocatalytic technologies, photocatalytic H 2 O 2 production is a viable solution for dealing with energy and environmental challenges, because of its minimal energy usage, security, and green credentials [6].…”