2000
DOI: 10.1016/s0944-7113(00)80006-9
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Chemomodulatory action of Aloe vera on the profiles of enzymes associated with carcinogen metabolism and antioxidant status regulation in mice

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Cited by 55 publications
(30 citation statements)
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“…41) In another study, fresh leaf pulp extract of Aloe vera caused a decrease in malondialdehyde (MDA) formation in liver, suggesting the plant's role in the protection of oxidant induced cellular damage. 42) In the examination of the enzymes characteristic for liver function, in the diabetic groups given Aloe pulp and gel extracts a decrease in serum ALT, in contrast to an increase in the group given glibenclamide (Table 2) shows that Aloe extracts are more beneficial for liver than this latter known hypoglycemic drug. Though ALP is a marker for different metabolic functions, which could also have been impaired by diabetes, Aloe pulp extract could have decreased ALT which is a mainly hepatic enzyme, but increased ALP.…”
Section: Discussionmentioning
confidence: 97%
“…41) In another study, fresh leaf pulp extract of Aloe vera caused a decrease in malondialdehyde (MDA) formation in liver, suggesting the plant's role in the protection of oxidant induced cellular damage. 42) In the examination of the enzymes characteristic for liver function, in the diabetic groups given Aloe pulp and gel extracts a decrease in serum ALT, in contrast to an increase in the group given glibenclamide (Table 2) shows that Aloe extracts are more beneficial for liver than this latter known hypoglycemic drug. Though ALP is a marker for different metabolic functions, which could also have been impaired by diabetes, Aloe pulp extract could have decreased ALT which is a mainly hepatic enzyme, but increased ALP.…”
Section: Discussionmentioning
confidence: 97%
“…(Malencic et al, 2000). Effect of the fresh leaf pulp extract of Aloe vera was effective in inducing SOD and CAT activities in mice (Singh et al, 2000). Treatment with Aloe vera caused a decrease in malondialdehyde (MDA) formation and the activity of lactate dehydrogenase in the liver.…”
Section: Discussionmentioning
confidence: 99%
“…Thereafter, phase II detoxification enzymes conjugate and guide these ions from the body (Sunkara et al, 2008). Singh et al (2000) reported that the fresh leaf pulp extract of Aloe vera significantly reduced the levels of phase I detoxification enzymes and increased those of phase II detoxification enzymes in the livers of mice. In the present study, the mRNA expression level of the phase II detoxification enzyme GST was found to be elevated.…”
Section: Discussionmentioning
confidence: 99%