Chemoprevention by white currant is mediated by the reduction of nuclear β-catenin and NF-κB levels in Min mice adenomas

Rajakangas, Johanna; Misikangas, Marjo; Päivärinta, Essi; Mutanen, Marja

doi:10.1007/s00394-008-0704-0

Cited by 32 publications

(20 citation statements)

References 43 publications

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“…It has been shown to reduce the incidence of a variety of carcinogen-induced tumors 20 . The anticarcinogenic effect of EA was shown in several types of cancers [21][22][23][24][25] . In our study we observed, EA at 25-200µM strikingly reduced the cell viability of U251 cells, suggesting the anti-proliferative efficacy.…”

Section: Discussionmentioning

confidence: 99%

Ellagic acid inhibits proliferation and induces apoptosis in human glioblastoma cells

et al. 2016

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PURPOSE:To investigate the anticancer activity of ellagic acid (EA) in U251 human glioblastoma cells and its possible molecular mechanism. METHODS:The cells were treated with EA at various concentrations for different time periods. Cell viability and cell proliferation were detected by cell counting kit-8(CCK-8) assay and live/dead assay respectively. Cell apoptosis were measured with Annexin V-FITC/PI double staining method by flow cytometry and Mitochondrial membrane potential assay separately. Cell cycle was measured with PI staining method by flow cytometry. The expressions of Bcl-2, Survivin, XIAP, Caspase-3, Bax, JNK, p-JNK, ERK1/2, p-ERK1/2, p38, p-p38, DR4, DR5, CHOP and GRP78-related proteins were detected by western blot after EA treatment. RESULTS:Cell viability and proliferation of glioblastoma cells treated with EA were significantly lower than the control group. EA caused robust apoptosis of the glioblastoma cells compared to the control group. EA significantly decreased the proportion at G0/ G1 phases of cell cycling accompanied by increased populations at S phase in U251 cell lines. And the expressions of anti-apoptotic proteins were dramatically down-regulated. CONCLUSION:Ellagic acid potentially up-regulated DR4, DR5 and MAP kinases (JNK, ERK1/2 and p38). EA also caused significant increase in the expressions of CHOP and GRP78. Our findings suggest that EA would be beneficial for the treatment of glioblastoma.

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Section: Discussionmentioning

confidence: 99%

Ellagic acid inhibits proliferation and induces apoptosis in human glioblastoma cells

et al. 2016

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“…Expression of various factors, such as iNOS, cyclooxygenase-2, etc., is associated with the upregulation of inflammatory processes that are regulated by NF-κB [23]. Colon cancer patients are reported to have high levels of active NF-κB, which stimulate tumor progression [24]. Results from the present study show that triptolide enhances PPARγ levels and reduces iNOS levels in HCT116 cells.…”

Section: Discussionmentioning

confidence: 50%

Prophylactic effects of triptolide on colon cancer development in azoxymethane/dextran sulfate sodiuminduced mouse model

Zhou¹,

Sun²,

Cui³

et al. 2018

Trop. J. Pharm Res

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“…As assessed by microarray analyses, with berry enriched diets the authors observed attenuation of genes implicated in colon carcinogenesis, including the decreased expression of the adenosine deaminase, ecto-5′-nucleotidase, and prostaglandin E2 receptor subtype EP4, thus suggesting some mechanistic evidence as to a potential explanation for the tumor risk reduction. In separate in vivo experiments also on Min mice, Rajakangas et al, showed that a 10% white currant dietary supplementation administered for 10 weeks can yield a significant reduction in the number and size of adenomas in the total small intestine, associated with reduced nuclear beta-catenin and NF-κB protein levels in the adenomas [60]. …”

Section: The Role Of Dietary Berries In Various Types Of Cancermentioning

confidence: 99%

Protective Role of Dietary Berries in Cancer

2016

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Dietary patterns, including regular consumption of particular foods such as berries as well as bioactive compounds, may confer specific molecular and cellular protection in addition to the overall epidemiologically observed benefits of plant food consumption (lower rates of obesity and chronic disease risk), further enhancing health. Mounting evidence reports a variety of health benefits of berry fruits that are usually attributed to their non-nutritive bioactive compounds, mainly phenolic substances such as flavonoids or anthocyanins. Although it is still unclear which particular constituents are responsible for the extended health benefits, it appears that whole berry consumption generally confers some anti-oxidant and anti-inflammatory protection to humans and animals. With regards to cancer, studies have reported beneficial effects of berries or their constituents including attenuation of inflammation, inhibition of angiogenesis, protection from DNA damage, as well as effects on apoptosis or proliferation rates of malignant cells. Berries extend effects on the proliferation rates of both premalignant and malignant cells. Their effect on premalignant cells is important for their ability to cause premalignant lesions to regress both in animals and in humans. The present review focuses primarily on in vivo and human dietary studies of various berry fruits and discusses whether regular dietary intake of berries can prevent cancer initiation and delay progression in humans or ameliorate patients’ cancer status.

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Chemoprevention by white currant is mediated by the reduction of nuclear β-catenin and NF-κB levels in Min mice adenomas

Abstract: This study shows that white currant is effective in preventing cancer initiation and progression in the Min mouse. Whether the positive effects are due to its special phenolic composition needs to be studied in more detail.

Cited by 32 publications

References 43 publications

Ellagic acid inhibits proliferation and induces apoptosis in human glioblastoma cells

Ellagic acid inhibits proliferation and induces apoptosis in human glioblastoma cells

Prophylactic effects of triptolide on colon cancer development in azoxymethane/dextran sulfate sodiuminduced mouse model

Protective Role of Dietary Berries in Cancer

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