Chemoprevention of azoxymethane-induced rat aberrant crypt foci by dietary zerumbone isolated from Zingiber zerumbet

Suppression of β-catenin and Cyclooxygenase-2 Expression and Cell Proliferation in Azoxymethane-Induced Colonic Cancer in Rats by Rice Bran Phytic Acid (PA)

“…Our finding was in line with the study by Takahashi et al (2000), which reported frequent mutation, and an altered cellular localization of β-catenin in rat colon adenocarcinomas induced by AOM, along with up-regulation of COX-2. The increased level of COX-2 proved evidence of an involvement of the Wnt-APC-ß-catenin/Tcf pathway in COX-2 expression as reported by Tanaka et al (2001).…”

Luteolin, a Bioflavonoid Inhibits Colorectal Cancer through Modulation of Multiple Signaling Pathways: A Review

“…Henceforth, assays of COX-2 expression may be used to monitor the process of carcinogenesis, and the suppression of COX-2 expression has become an important target for treatment and prevention of CRC (Tanaka et al, 2001;Turini and DuBois, 2002;Hamiza et al, 2012). COX-2 is induced by inflammatory cells, by various stimuli including cytokines, growth factors and tumor inducing factors.…”

Key cell signaling pathways modulated by zerumbone: Role in the prevention and treatment of cancer

“…In the first published in vivo study with zerumbone, Tanaka and coworkers reported that oral administration of the sesquiterpene suppressed azoxymethane-induced colonic aberrant crypt foci in male F344 rats in a dose-dependent manner [64]. Subsequently, Murakami and co-workers reported that oral administration of zerumbone caused suppression of dextran sodium sulfate-induced acute colitis in female ICR mice [65].…”