Chemoprevention of mammary tumor virus-induced and chemical carcinogen-induced rodent mammary tumors by natural plant products

Bhide, S. V.; Azuine, Magnus A.; Moushumi, Lahiri; Telang, Nitin T.

doi:10.1007/bf00665965

Cited by 45 publications

(14 citation statements)

References 25 publications

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“…The antimutagenic and chemopreventive potential of turmeric has been sufficiently documented [31][32][33][34]. The aqueous extract of turmeric has been reported to inhibit lipid peroxidation, affording protection to DNA against free radical attack [35].…”

Section: Discussionmentioning

confidence: 99%

Biomonitoring the Chemopreventive Potential of the Plant Products Neem and Turmeric in 4-Nitroquinoline 1-Oxide-Induced Oral Carcinogenesis.

Nagini

Manoharan

1997

J. Clin. Biochem. Nutr.

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Section: Discussionmentioning

confidence: 99%

Biomonitoring the Chemopreventive Potential of the Plant Products Neem and Turmeric in 4-Nitroquinoline 1-Oxide-Induced Oral Carcinogenesis.

Nagini

Manoharan

1997

J. Clin. Biochem. Nutr.

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“…8,25 Furthermore, numerous in vivo studies have demonstrated a decrease in tumor initiation and growth following curcumin [26][27][28][29][30][31] or EGCG administration. 8,[32][33][34][35][36] For example, EGCG and green tea extracts were both recently shown to decrease tumor incidence and burden in athymic mice inoculated with MDA-MB-231 (ERa-) human breast cancer cells. 8,36 A potential mechanism for this effect is via inhibition of the epidermal growth factor receptor (EGFR), which is overexpressed in ERa-breast cancer cells 37 and patients.…”

Section: Abstract: Egcg; Curcumin; Mda-mb-231 Cells; Vegfr-1mentioning

confidence: 99%

The combination of epigallocatechin gallate and curcumin suppresses ERα‐breast cancer cell growth in vitro and in vivo

Somers-Edgar

Scandlyn

Stuart

et al. 2008

Intl Journal of Cancer

121

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Both epigallocatechin gallate (EGCG) and curcumin have shown efficacy in various in vivo and in vitro models of cancer. This study was designed to determine the efficacy of these naturally derived polyphenolic compounds in vitro and in vivo, when given in combination. Studies in MDA-MB-231 cells demonstrated that EGCG 1 curcumin was synergistically cytotoxic and that this correlated with G 2 /M-phase cell cycle arrest. After 12 hr, EGCG (25 lM) 1 curcumin (3 lM) increased the proportion of cells in G 2 /M-phase to 263 6 16% of control and this correlated with a 50 6 4% decrease in cell number compared to control. To determine if this in vitro result would translate in vivo, athymic nude female mice were implanted with MDA-MB-231 cells and treated with curcumin (200 mg/kg/day, po), EGCG (25 mg/kg/day, ip), EGCG 1 curcumin, or vehicle control (5 ml/kg/day, po) for 10 weeks. Tumor volume in the EGCG 1 curcumin treated mice decreased 49% compared to vehicle control mice (p < 0.05), which correlated with a 78 6 6% decrease in levels of VEGFR-1 protein expression in the tumors. Curcumin treatment significantly decreased tumor protein levels of EGFR and Akt, however the expression of these proteins was not further decreased following combination treatment. Therefore, these results demonstrate that the combination of EGCG and curcumin is efficacious in both in vitro and in vivo models of ERa-breast cancer and that regulation of VEGFR-1 may play a key role in this effect. ' 2007 Wiley-Liss, Inc.

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“…It was observed that when betel leaf extract was fed to rats bearing mammary tumors in the initiation phase, the tumor growth was prevented, while rats with fully developed mammary tumors failed to show any reduction/inhibition in tumor growth (52,53). We have recently reported that betel leaf extract exhibits significant efficacy in inhibiting growth of prostate cancer xenografts (20).…”

Section: Betel Nutraceuticals Offer Chemopreventive Benefits: Potentimentioning

confidence: 99%

Piper Betel Leaf: A Reservoir of Potential Xenohormetic Nutraceuticals with Cancer-Fighting Properties

Gundala

Aneja

2014

Cancer Prevention Research

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Plants contain a much greater diversity of bioactive compounds than any man-made chemical library. Heart-shaped Piper betel leaves are magnificent reservoirs of phenolic compounds with antiproliferative, antimutagenic, antibacterial, and antioxidant properties. Widely consumed in South Asian countries, the glossy leaf contains a multitude of biophenolics such as hydroxychavicol, eugenol, chavibetol, and piperols. Convincing data underscore the remarkable chemotherapeutic and chemopreventive potential of betel leaves against a variety of cancer types. The leaf constituents modulate an extensive array of signaling molecules such as transcription factors as well as reactive oxygen species (ROS) to control multiple nodes of various cellular proliferation and death pathways. Herein, we provide an overall perspective on the cancerfighting benefits of the phenolic phytochemicals in betel leaves and a comprehensive overview of the mechanisms responsive to dose-driven ROS-mediated signaling cascades conscripted by bioactive phenolics to confer chemotherapeutic and chemopreventive advantages. Intriguingly, these ROS-triggered responses are contextual and may either elicit a protective xenohormetic antioxidant response to premalignant cells to constitute a chemopreventive effect or generate a curative chemotherapeutic response by pro-oxidatively augmenting the constitutively elevated ROS levels in cancer cells to tip the balance in favor of selective apoptosis induction in cancer cells while sparing normal ones. In conclusion, this review provides an update on how distinct ROS levels exist in normal versus cancer cells and how these levels can be strategically modulated and exploited for therapeutic gains. We emphasize the yet untapped potential of the evergreen vine, betel leaf, for chemopreventive and chemotherapeutic management of cancer. Cancer Prev Res; 7(5);

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Chemoprevention of mammary tumor virus-induced and chemical carcinogen-induced rodent mammary tumors by natural plant products

Cited by 45 publications

References 25 publications

Biomonitoring the Chemopreventive Potential of the Plant Products Neem and Turmeric in 4-Nitroquinoline 1-Oxide-Induced Oral Carcinogenesis.

Biomonitoring the Chemopreventive Potential of the Plant Products Neem and Turmeric in 4-Nitroquinoline 1-Oxide-Induced Oral Carcinogenesis.

The combination of epigallocatechin gallate and curcumin suppresses ERα‐breast cancer cell growth in vitro and in vivo

Piper Betel Leaf: A Reservoir of Potential Xenohormetic Nutraceuticals with Cancer-Fighting Properties

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