Chemopreventive activity of grape juice concentrate (G8000TM) on rat colon carcinogenesis induced by azoxymethane

Silva, Roseane Mendes; Campanholo, Vanessa Maria de Lima Pazine; Paiotti, Ana Paula Ribeiro; Neto, Ricardo Artigiani; Oshima, Celina Tizuko Fujiyama; Ribeiro, Daniel Araki; Forones, Nora Manoukian

doi:10.1016/j.etap.2015.09.012

Cited by 9 publications

(2 citation statements)

References 33 publications

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“…The results are promising with inhibition of tumor development associated with reduced phosphorylation of PI3K/Akt, declining levels of NF-κB and decreased expression of pro-inflammatory markers [160]. Recent researches have shown that administration of grape juice concentrate rich in phenolic compounds ( peonidin glucoside , malvidin-glucoside ) reduced inflammation, through decreased expression of COX-2, if taken before or after induction of colon cancer [161]. Other authors reported that administration of anthocyanin-rich diet in an animal model of CRC showed significant reduction of colon tumors and a positive effect on gut microbiota [162].…”

Section: In Vivo Studies In Crc Animal Modelsmentioning

confidence: 99%

Chemoprevention of Colorectal Cancer by Dietary Compounds

Costea

Hudiţă

Ciolac

et al. 2018

IJMS

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Colorectal cancer is one of the leading causes of death, and the third most diagnosed type of cancer, worldwide. It is most common amongst men and women over 50 years old. Risk factors include smoking, alcohol, diet, physical inactivity, genetics, alterations in gut microbiota, and associated pathologies (diabetes, obesity, chronic inflammatory bowel diseases). This review will discuss, in detail, the chemopreventive properties of some dietary compounds (phenolic compounds, carotenoids, iridoids, nitrogen compounds, organosulfur compounds, phytosterols, essential oil compounds, polyunsaturated fatty acids and dietary fiber) against colorectal cancer. We present recent data, focusing on in vitro, laboratory animals and clinical trials with the previously mentioned compounds. The chemopreventive properties of the dietary compounds involve multiple molecular and biochemical mechanisms of action, such as inhibition of cell growth, inhibition of tumor initiation, inhibition of adhesion, migration and angiogenesis, apoptosis, interaction with gut microbiota, regulation of cellular signal transduction pathways and xenobiotic metabolizing enzymes, etc. Moreover, this review will also focus on the natural dietary compounds’ bioavailability, their synergistic protective effect, as well as the association with conventional therapy. Dietary natural compounds play a major role in colorectal chemoprevention and continuous research in this field is needed.

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Section: In Vivo Studies In Crc Animal Modelsmentioning

confidence: 99%

Chemoprevention of Colorectal Cancer by Dietary Compounds

Costea

Hudiţă

Ciolac

et al. 2018

IJMS

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show abstract

“…The underlying molecular mechanisms involved to this event are not fully understood, but several mechanisms have been purposed so far. The Thieme first mechanism resides on the fact that flavonoids are able to inhibit COX-2; COX-2 is a redox-sensitive transcription factor being activated by oxidative stress following inflammatory process in the colonic mucosa [28]. In the present study, M. caesalpiniifolia was able to inhibit COX-2 immunoexpression when administrated at 250 mg after inducing colitis induction and 50 mg of ethylacetate fraction.…”

Section: Thiemementioning

confidence: 45%

The Anti-Inflammatory Potential of Mimosa caesalpiniifolia Following Experimental Colitis: Role of COX-2 and TNF-Alpha Expression

et al. 2017

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The aim of this study was to evaluate the preventive and/or protective action of Mimosa caesalpiniifolia (M. caesalpiniifolia) following experimental colitis in rats. The rats were randomized into ten groups (n=10 per group), as follows: G1 - Sham group:; G2 - TNBS group; G3, G4 -colitis and treated with hydroalcoholic extract of M. caesalpiniifolia 250 mg/kg/day after and before/after inducing colitis, respectively; G5, G6 - colitis and treated with hydroalcoholic extract of M. caesalpiniifolia at 125 mg/kg/day after and before/after inducing colitis respectively; G7,G8 - colitis and treated with ethylacetate fraction of M. caesalpiniifolia at 50 mg/kg/day after and before/after inducing colitis, respectively; G9,G10 - colitis and treated with ethylacetate fraction of M. caesalpiniifolia at 50 mg/kg/day after and before/after inducing colitis, respectively. Rats treated with hydroalcoholic extract of M. caesalpiniifolia for both doses showed lower tissue damage in the distal colon. Ethylacetate fraction was effective at the highest dose only when administrated after inducing colitis. A downregulation of COX-2 was detected to rats suffering colitis and treated with M. caesalpiniifolia at high dose. On the other hand, TNF-alpha immunoexpression decreased in groups treated with M. caesalpiniifolia at low dose after inducing colitis. In summary, our results suggest that M. caesalpiniifolia attenuated the lesions of the colon, reduced inflammation, and modulates the expression of COX-2 and TNF-α during chronic colitis induced by TNBS when using for therapeutic purposes on a dose-dependent manner.

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Review of the Pharmacological Effects ofVitis vinifera(Grape) and its Bioactive Constituents: An Update

2016

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Vitis vinifera fruit (grape) contains various phenolic compounds, flavonoids and stilbenes. In recent years, active constituents found in the fruits, seeds, stems, skin and pomaces of grapes have been identified and some have been studied. In this review, we summarize the active constituents of different parts of V. vinifera and their pharmacological effects including skin protection, antioxidant, antibacterial, anticancer, antiinflammatory and antidiabetic activities, as well as hepatoprotective, cardioprotective and neuroprotective effects in experimental studies published after our 2009 review. Clinical and toxicity studies have also been examined. Copyright © 2016 John Wiley & Sons, Ltd.

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Chemopreventive activity of grape juice concentrate (G8000TM) on rat colon carcinogenesis induced by azoxymethane

Cited by 9 publications

References 33 publications

Chemoprevention of Colorectal Cancer by Dietary Compounds

Chemoprevention of Colorectal Cancer by Dietary Compounds

The Anti-Inflammatory Potential of Mimosa caesalpiniifolia Following Experimental Colitis: Role of COX-2 and TNF-Alpha Expression

Review of the Pharmacological Effects ofVitis vinifera(Grape) and its Bioactive Constituents: An Update

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