Chemopreventive allylthiopyridazines inhibit invasion, migration and angiogenesis in hepatocarcinoma cells

Lee, Eunjung; Shin, Injae; Kwon, Soon-Kyoung; Shin, Hea-Soon; Moon, Aree

doi:10.3892/ijo.23.6.1645

Cited by 3 publications

(5 citation statements)

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“…Angiogenesis inhibitors show promise as anti-cancer agents as they can act in both pre-invasive and invasive stages of cancer (Lee et al, 2003;Muehlbauer, 2003). Favourably, endothelial cell recruitment and proliferation is a central phenomenon of all cancer types and these cells are inherently stable and exhibit low mutagenesis rate, thereby reducing chances of multi-drug resistance (Tosetti et al, 2002;Bisacchi et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of the effect of Withania somnifera root extracts on cell cycle and angiogenesis

Mathur

Gupta

Singh

et al. 2006

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 99%

“…In this direction, plants are being actively explored as a source of new molecules that can curtail cancer growth (Dredge et al, 2003;Lee et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the effect of Withania somnifera root extracts on cell cycle and angiogenesis

Mathur

Gupta

Singh

et al. 2006

Journal of Ethnopharmacology

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“…There is growing interest in the inclusion of pine needle‐based products in the diet because of their health‐promoting properties. Extract of red pine (RP) plants exhibits anti‐inflammatory and antioxidative activities, and it has been reported that pine needles exert antiproliferative effects 4 …”

Section: Introductionmentioning

confidence: 99%

“…Extract of red pine (RP) plants exhibits antiinflammatory and antioxidative activities, and it has been reported that pine needles exert antiproliferative effects. 4 Several studies have implicated upregulation of MMPs in the development of liver cancer. 5 Hepatocellular carcinoma is the most frequent malignant tumor of the liver.…”

Section: Introductionmentioning

confidence: 99%

Phenolic Phytochemicals Derived from Red Pine (Pinus densiflora) Inhibit the Invasion and Migration of SK‐Hep‐1 Human Hepatocellular Carcinoma Cells

Lee

Hur

et al. 2007

Annals of the New York Academy of Sciences

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Considerable attention has recently been focused on identifying chemopreventive phytochemicals derived from medicinal plants. Here, we analyzed phenolic phytochemicals from red pine (RP) leaves and found epigallocatechin gallate (EGCG) and epigallocatechin (EGC), and catechin gallate (CG) as their major phenolic phytochemicals. This article also investigated whether RP leaf extract and its phenolic phytochemicals inhibit the invasion of SK-Hep-1 human hepatocellular carcinoma cells (SK-Hep-1 cells). RP suppressed the invasion and the migration of SK-Hep-1 cells. EGCG and CG also inhibited the invasion and migration, with EGC exhibiting a lower efficacy. Matrix metalloproteinases (MMPs), particularly gelatinase-A (MMP-2) and gelatinase-B (MMP-9), degrade components of the basement membrane and are strongly implicated in invasion and metastasis formation of malignant tumors. RP suppressed both MMP-2 and MMP-9 activities. EGCG and CG reduced the activities of MMP-9 and MMP-2 in a dose-dependent manner, with EGC exhibiting a lower efficacy on both MMPs. Our results suggest that RP inhibits tumor invasion and migration, which may be attributed to the effects of EGCG and CG. In particular, EGCG plays a key role in the efficacy of RP against hepatocarcinogenesis.

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“…The migration assay of the tumor cells was carried out as above without coating the polycarbonate filter with collagen. The number of migrated cells in the lower compartment was counted by a hemocytometer (Lee et al , ).…”

Section: Methodsmentioning

confidence: 99%

Berberine Inhibits Pulmonary Metastasis through Down‐regulation of MMP in Metastatic B16F‐10 Melanoma Cells

Purayil

Kuttan

2011

Phytotherapy Research

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The present study demonstrated the potential antimetastatic and antiinvasive effect of berberine using both in vivo mouse lung metastasis and in vitro models. Administration of berberine resulted in significant suppression of B16F-10 melanoma induced tumor nodule formation and enhanced the survival of tumor-bearing mice. Berberine treatment also decreased various biochemical parameters associated with lung metastasis. These inhibitory actions may be due to the significant suppression of several signaling molecules such as ERK1/2, NF-κB, ATF-2 and CREB involved in the transcription signaling pathways for MMP gene expression. It could also inhibit the migration and invasion of highly metastatic murine melanoma cells in a dose-dependent manner in vitro. The results clearly show that berberine could significantly inhibit experimental lung metastasis produced by intravenous injection of B16F-10 melanoma cells and this effect could be linked to the down-regulation of metastasis-related signaling molecules.

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Chemopreventive allylthiopyridazines inhibit invasion, migration and angiogenesis in hepatocarcinoma cells

Cited by 3 publications

References 0 publications

Evaluation of the effect of Withania somnifera root extracts on cell cycle and angiogenesis

Evaluation of the effect of Withania somnifera root extracts on cell cycle and angiogenesis

Phenolic Phytochemicals Derived from Red Pine (Pinus densiflora) Inhibit the Invasion and Migration of SK‐Hep‐1 Human Hepatocellular Carcinoma Cells

Berberine Inhibits Pulmonary Metastasis through Down‐regulation of MMP in Metastatic B16F‐10 Melanoma Cells

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