Chemopreventive and antioxidant efficacy of (6)-paradol in 7, 12-dimethylbenz(a)anthracene induced hamster buccal pouch carcinogenesis

Suresh, K.; Manoharan, Shanmugam; Vijayaanand, Mariadoss Arokia; Govindasamy, S.

doi:10.1016/s1734-1140(10)70380-7

Cited by 47 publications

(32 citation statements)

References 38 publications

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“…In another report, both 6-GIN and 6-PAR were shown to induce apoptosis in HL-60 leukemia cells (46). 6-PAR treatment also induced apoptosis and caspase-3 activation in an oral squamous carcinoma cell line and demonstrated chemopreventive and antioxidant activity in the 7,12-dimethylbenz(a)anthracene (DMBA)-induced hamster buccal pouch carcinogenesis assay (47,48). As shown in Fig.…”

Section: Discussionmentioning

confidence: 76%

6-Shogaol from Dried Ginger Inhibits Growth of Prostate Cancer Cells Both In Vitro and In Vivo through Inhibition of STAT3 and NF-κB Signaling

Saha

Blando

Silver

et al. 2014

Cancer Prevention Research

136

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Despite much recent progress, prostate cancer continues to represent a major cause of cancer-related mortality and morbidity in men. Prostate cancer is the most common nonskin neoplasm and second leading cause of death in men. 6-Shogaol (6-SHO), a potent bioactive compound in ginger (Zingiber officinale Roscoe), has been shown to possess anti-inflammatory and anticancer activity. In the present study, the effect of 6-SHO on the growth of prostate cancer cells was investigated. 6-SHO effectively reduced survival and induced apoptosis of cultured human (LNCaP, DU145, and PC3) and mouse (HMVP2) prostate cancer cells. Mechanistic studies revealed that 6-SHO reduced constitutive and interleukin (IL)-6-induced STAT3 activation and inhibited both constitutive and TNF-a-induced NF-kB activity in these cells. In addition, 6-SHO decreased the level of several STAT3 and NF-kB-regulated target genes at the protein level, including cyclin D1, survivin, and cMyc and modulated mRNA levels of chemokine, cytokine, cell cycle, and apoptosis regulatory genes (IL-7, CCL5, BAX, BCL2, p21, and p27). 6-SHO was more effective than two other compounds found in ginger, 6-gingerol, and 6-paradol at reducing survival of prostate cancer cells and reducing STAT3 and NF-kB signaling. 6-SHO also showed significant tumor growth inhibitory activity in an allograft model using HMVP2 cells. Overall, the current results suggest that 6-SHO may have potential as a chemopreventive and/or therapeutic agent for prostate cancer and that further study of this compound is warranted. Cancer Prev Res; 7(6); 627-38. Ó2014 AACR.

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Section: Discussionmentioning

confidence: 76%

6-Shogaol from Dried Ginger Inhibits Growth of Prostate Cancer Cells Both In Vitro and In Vivo through Inhibition of STAT3 and NF-κB Signaling

Saha

Blando

Silver

et al. 2014

Cancer Prevention Research

136

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“…[41] All this may contribute to the kinetics of elimination of these metals from the system. Our observations were that Zingiber officinale had less percentage protection over Pb exposures.…”

Section: Discussionmentioning

confidence: 99%

Comparative study on the hepatoprotection to heavy metals of Zingiber officinale

Nwokocha¹,

Owu²,

Nwokocha³

et al. 2012

Phcog Res

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Context:Zingiber officinale (Zingiberaceae) is a herb used for culinary and therapeutic purposes due to its anti-inflammatory and antioxidant potentials.Objectives:We examined its protective ability against mercury (Hg), lead (Pb) and cadmium (Cd) accumulation in the liver.Materials & Methods:Ground Zingiber officinale (7%, w/w of feed) was administered to rats either at the same time with the exposure ofheavy metals (group 2), a week after exposure to heavy metals (group 3) or given a week before heavy metal exposure (group 4) for six weeks. Animals were exposed to either of Hg (10 ppm), Cd (200 ppm) and Pb (100 ppm) in drinking water. The heavy metal accumulations in the liver were determined using AAS.Results:Weight losses induced by these metals were not reversed by Zingiber officinale administration. There was a significant (P<0.01) increase in protection to Pb (97%) and Cd (63%) accumulation when compared to Hg (32%) at week 2. The protective ability was significantly (P<0.01) decreased at week 4 when compared to week 2 for Cd and Pb but not to Hg in groups 3 (50%) and 4 (52%). At week 6, hepatoprotection to Hg (44%) and Cd (85%) was significantly (P<0.01) different but not to Pb which was only significant (P<0.05) in week 2 of treatment for all groups.Discussion and Conclusion:Zingiber officinale affected the bioavailability, elimination and uptake of these metals in a time-dependent way with highest beneficial reducing effect to Cd followed by Hg and least protection to Pb in the liver.

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“…Due to their structural similarity, several other polyphenols are considered as HCA analogs [72]. For instance, the phenylethanol derivatives, which comprise the 3,4-dihydroxy phenylethanol (hydroxytyrosol) and the 4-hydroxyphenyl ethanol (tyrosol), the curcumin and derivatives, such as yakuchinone A and yakuchinone B, the capsaicin and dihydrocapsaicin and derivatives, rosmarinic acid and derivatives, [6]-gingerol, [6]-paradol and derivatives are also considered as antioxidant components of diet and a natural inspiration for the development of new potent and effective antioxidants [73][74][75][76]. One of the most important HCA derivatives is chloro-genic acid (CGA) which has been reported as an efficient antioxidant agent [56,57].…”

mentioning

confidence: 99%

Antioxidant Properties of Hydroxycinnamic Acids: A Review of Structure- Activity Relationships

Razzaghi‐Asl¹,

Garrido²,

Khazraei³

et al. 2013

CMC

172

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Hydroxycinnamic acids (HCAs) are important phytochemicals possessing significant biological properties. Several investigators have studied in vitro antioxidant activity of HCAs in detail. In this review, we have gathered the studies focused on the structure-activity relationships (SARs) of these compounds that have used medicinal chemistry to generate more potent antioxidant molecules. Most of the reports indicated that the presence of an unsaturated bond on the side chain of HCAs is vital to their activity. The structural features that were reported to be of importance to the antioxi-dant activity were categorized as follows: modifications of the aromatic ring, which include alterations in the number and position of hydroxy groups and insertion of electron donating or withdrawing moieties as well as modifications of the car-boxylic function that include esterification and amidation process. Furthermore, reports that have addressed the influence of physicochemical properties including redox potential, lipid solubility and dissociation constant on the antioxidant activ-ity were also summarized. Finally, the pro-oxidant effect of HCAs in some test systems was addressed. Most of the investigations concluded that the presence of ortho-dihydroxy phenyl group (catechol moiety) is of significant importance to the antioxidant activity, while, the presence of three hydroxy groups does not necessarily improve the activity. Optimiza-tion of the structure of molecular leads is an important task of modern medicinal chemistry and its accomplishment relies on the careful assessment of SARs. SAR studies on HCAs can identify the most successful antioxidants that could be use-ful for management of oxidative stress-related diseases.Keywords: Antioxidant, hydroxycinnamic acids, in vitro, ROS, structure-activity relationships. OXIDATIVE STRESS AND ANTIOXIDANTSReactive oxygen species (ROS) are oxygen derived molecules that readily react with other compounds and macromolecules and oxidize them. Some representative exam-ples of these species include superoxide (O2•-), hydroxy (HO • ) and peroxy (ROO • ) radicals, hydrogen peroxide (H2O2) and singletROS are involved in important physiological processes such as immune response, gene expression, signal transduc-tion and growth regulation [5,6]; however if they are not kept under tight control by physiological antioxidant systems they will be able to oxidize and damage various biological molecules leading to a condition called oxidative stress [1,7,8]. In this regard, oxidative stress has been reported to be in-volved in the pathogenesis of diseases such as cancer [9], neurodegenerative diseases [10], stroke [11], and others [12,13].Since an important source of ROS comes from environment [14], with the industrial development and the change in life style, oxidative stress related diseases need a special attention [15].Antioxidants operate by preventing or slowing the progression of oxidative damage reactions [16,17]. An antioxidant has been defined as "any substance that delays, p...

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Chemopreventive and antioxidant efficacy of (6)-paradol in 7, 12-dimethylbenz(a)anthracene induced hamster buccal pouch carcinogenesis

Cited by 47 publications

References 38 publications

6-Shogaol from Dried Ginger Inhibits Growth of Prostate Cancer Cells Both In Vitro and In Vivo through Inhibition of STAT3 and NF-κB Signaling

6-Shogaol from Dried Ginger Inhibits Growth of Prostate Cancer Cells Both In Vitro and In Vivo through Inhibition of STAT3 and NF-κB Signaling

Comparative study on the hepatoprotection to heavy metals of Zingiber officinale

Antioxidant Properties of Hydroxycinnamic Acids: A Review of Structure- Activity Relationships

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