Chemopreventive aspects, investigational anticancer applications and current perspectives on allyl isothiocyanate (AITC): a review

Patil, Prasad; Patel, Jayvadan K.

doi:10.1007/s11010-023-04697-0

Cited by 6 publications

(2 citation statements)

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“…SFN at high doses suppressed tumor growth and cell proliferation, while at low concentrations, both were increased [133]. The same hormetic trend was shown in the modulation of GSH amount, suggesting that its close interaction with ITCs is strictly correlated with its antitumor and antiproliferative activities [134,135]. Such an effect can be explained since tumor cells show a high GSH content that readily interacts with elevated concentrations of ITCs, causing intracellular accumulation of GSH conjugate derivatives accountable for the antitumor activities [136].…”

Section: Glucosinolates and Gshmentioning

confidence: 66%

“…Despite their well-documented anticancer activities (Table 3), ITCs have been found to exhibit hormetic activities in tumor cells, which involve GSH amount in a biphasic dose-response relationship, wherein low doses of these compounds can induce beneficial effects while high doses may be detrimental in different cancer models in vitro and in vivo [133][134][135]. The modulatory effects of ITCs on GSH homeostasis and its hormetic activities are significant and hold great potential for therapeutic applications.…”

Section: Glucosinolates and Gshmentioning

confidence: 99%

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Natural Compounds and Glutathione: Beyond Mere Antioxidants

et al. 2023

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The tripeptide glutathione plays important roles in many cell processes, including differentiation, proliferation, and apoptosis; in fact, disorders in glutathione homeostasis are involved both in the etiology and in the progression of several human diseases, including cancer. Natural compounds have been found to modulate glutathione levels and function beyond their role as mere antioxidants. For example, certain compounds can upregulate the expression of glutathione-related enzymes, increase the availability of cysteine, the limiting amino acid for glutathione synthesis, or directly interact with glutathione and modulate its function. These compounds may have therapeutic potential in a variety of disease states where glutathione dysregulation is a contributing factor. On the other hand, flavonoids’ potential to deplete glutathione levels could be significant for cancer treatment. Overall, while natural compounds may have potential therapeutic and/or preventive properties and may be able to increase glutathione levels, more research is needed to fully understand their mechanisms of action and their potential benefits for the prevention and treatment of several diseases. In this review, particular emphasis will be placed on phytochemical compounds belonging to the class of polyphenols, terpenoids, and glucosinolates that have an impact on glutathione-related processes, both in physiological and pathological conditions. These classes of secondary metabolites represent the most food-derived bioactive compounds that have been intensively explored and studied in the last few decades.

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