Chemopreventive effect of carvacrol on 1,2-dimethylhydrazine induced experimental colon carcinogenesis

Arivalagan, S.; Gunasekaran, S.; Nalini, Namasivayam

doi:10.4103/0973-1482.154925

Cited by 38 publications

(12 citation statements)

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“…In the current study, the major markers of oxidative stress response were found to be increased including LPO and NO, concurrently with the depletion of glutathione (GSH) and related redox cycle enzymes like SOD and CAT. Lipid peroxidation is one of the important markers of oxidative damage and high level of MDA, the end products of lipid peroxidation, has been found after DMH treatment [18-19]. Consistent with previous studies, our findings also showed noteworthy elevation in the level of LPO after DMH injection.…”

Section: Discussionsupporting

confidence: 82%

Bone Marrow Cell Therapy on 1,2-Dimethylhydrazine (DMH)-Induced Colon Cancer in Rats

El‐Khadragy

Nabil

Hassan

et al. 2018

Cell Physiol Biochem

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Background/Aims: Stem cell based therapies are being under focus due to their possible role in treatment of various tumors. Bone marrow stem cells believed to have anticancer potential and are preferred for their activities by stimulating the immune system, migration to the site of tumor and ability for inducting apoptosis in cancer cells. The current study was aimed to investigate the tumor suppressive effects of bone marrow cells (BMCs) in 1,2-dimethylhydrazine (DMH)-induced colon cancer in rats. Methods: The rats were randomly allocated into four groups: control, BMCs alone, DMH alone and BMCs with DMH. BMCs were injected intrarectally while DMH was injected subcutaneously at 20 mg/kg body weight once a week for 15 weeks. Histopathological examination and gene expression of survivin, β-catenin and multidrug resistance-1 (MDR-1) by real-time reverse transcription-polymerase chain reaction (RT-PCR) in rat colon tissues. This is in addition to oxidative stress markers in colon were performed across all groups. Results: The presence of aberrant crypt foci was reordered once histopathological examination of colon tissue from rats which received DMH alone. Administration of BMCs into rats starting from zero-day of DMH injection improved the histopathological picture which showed a clear improvement in mucosal layer, few inflammatory cells infiltration periglandular and in the lamina propria. Gene expression in rat colon tissue demonstrated that BMCs down-regulated survivin, β-catenin, MDR-1 and cytokeratin 20 genes expression in colon tissues after colon cancer induction. Amelioration of the colon status after administration of MSCs has been evidenced by a major reduction of lipid peroxidation, nitric oxide, and increasing of glutathione content and superoxide dismutase along with catalase activities. Conclusion: Our findings demonstrated that BMCs have tumor suppressive effects in DMH-induced colon cancer as evidenced by down-regulation of survivin, β-catenin, and MDR-1 genes and enhancing the antioxidant activity.

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Section: Discussionsupporting

confidence: 82%

Bone Marrow Cell Therapy on 1,2-Dimethylhydrazine (DMH)-Induced Colon Cancer in Rats

El‐Khadragy

Nabil

Hassan

et al. 2018

Cell Physiol Biochem

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“…Carvacrol supplementation significantly improved the weight gain and growth rate of animals with colon cancer induced by 1,2-dimethylhydrazine (DMH), exhibiting a lower incidence of tumors and pre-neoplastic lesions, along with a reduction in oxidative stress damage (higher levels of GSH, GPx, GR, SOD and CAT), suggesting that carvacrol presents chemopreventive effects ( Sivaranjani et al, 2016 ).…”

Section: Resultsmentioning

confidence: 99%

“…Carvacrol supplementation significantly improved the weight gain and growth rate of animals with colon cancer induced by 1,2dimethylhydrazine (DMH), exhibiting a lower incidence of tumors and pre-neoplastic lesions, along with a reduction in oxidative stress damage (higher levels of GSH, GPx, GR, SOD and CAT), suggesting that carvacrol presents chemopreventive effects (Sivaranjani et al, 2016). Li et al (2019) showed that tumor growth in mice with DENinduced hepatocarcinoma and treated with carvacrol was limited, revealing tumor cell reduction, rare mitotic figures, normal arrangement of cells, few microvessels, a central necrotic area on tumor tissue and a reduction of intrastromal and peritumor lymphocytes.…”

Section: Description Of In Vivo Studies With Carvacrol and Thymolmentioning

confidence: 99%

Antitumor Effects of Carvacrol and Thymol: A Systematic Review

et al. 2021

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Background: It is estimated that one in five people worldwide faces a diagnosis of a malignant neoplasm during their lifetime. Carvacrol and its isomer, thymol, are natural compounds that act against several diseases, including cancer. Thus, this systematic review aimed to examine and synthesize the knowledge on the antitumor effects of carvacrol and thymol.Methods: A systematic literature search was carried out in the PubMed, Web of Science, Scopus and Lilacs databases in April 2020 (updated in March 2021) based on the PRISMA 2020 guidelines. The following combination of health descriptors, MeSH terms and their synonyms were used: carvacrol, thymol, antitumor, antineoplastic, anticancer, cytotoxicity, apoptosis, cell proliferation, in vitro and in vivo. To assess the risk of bias in in vivo studies, the SYRCLE Risk of Bias tool was used, and for in vitro studies, a modified version was used.Results: A total of 1,170 records were identified, with 77 meeting the established criteria. The studies were published between 2003 and 2021, with 69 being in vitro and 10 in vivo. Forty-three used carvacrol, 19 thymol, and 15 studies tested both monoterpenes. It was attested that carvacrol and thymol induced apoptosis, cytotoxicity, cell cycle arrest, antimetastatic activity, and also displayed different antiproliferative effects and inhibition of signaling pathways (MAPKs and PI3K/AKT/mTOR).Conclusions: Carvacrol and thymol exhibited antitumor and antiproliferative activity through several signaling pathways. In vitro, carvacrol appears to be more potent than thymol. However, further in vivo studies with robust methodology are required to define a standard and safe dose, determine their toxic or side effects, and clarify its exact mechanisms of action.This systematic review was registered in the PROSPERO database (CRD42020176736) and the protocol is available at https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=176736.

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“…). Administration of carvacrol to adult male albino rats with chemical induced CRC, revealed that carvacrol reduced the number of colon tumors, dysplastic polyps, aberrant crypts foci, increased glutathione peroxidase and glutathione reductase activities and restored levels of liver peroxidation products [183]. Moreover, combined treatment between carvacrol and X-radiation significantly decreased tumor incidence [200].…”

Section: In Vivo Studies In Crc Animal Modelsmentioning

confidence: 99%

Chemoprevention of Colorectal Cancer by Dietary Compounds

Costea

Hudiţă

Ciolac

et al. 2018

IJMS

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Colorectal cancer is one of the leading causes of death, and the third most diagnosed type of cancer, worldwide. It is most common amongst men and women over 50 years old. Risk factors include smoking, alcohol, diet, physical inactivity, genetics, alterations in gut microbiota, and associated pathologies (diabetes, obesity, chronic inflammatory bowel diseases). This review will discuss, in detail, the chemopreventive properties of some dietary compounds (phenolic compounds, carotenoids, iridoids, nitrogen compounds, organosulfur compounds, phytosterols, essential oil compounds, polyunsaturated fatty acids and dietary fiber) against colorectal cancer. We present recent data, focusing on in vitro, laboratory animals and clinical trials with the previously mentioned compounds. The chemopreventive properties of the dietary compounds involve multiple molecular and biochemical mechanisms of action, such as inhibition of cell growth, inhibition of tumor initiation, inhibition of adhesion, migration and angiogenesis, apoptosis, interaction with gut microbiota, regulation of cellular signal transduction pathways and xenobiotic metabolizing enzymes, etc. Moreover, this review will also focus on the natural dietary compounds’ bioavailability, their synergistic protective effect, as well as the association with conventional therapy. Dietary natural compounds play a major role in colorectal chemoprevention and continuous research in this field is needed.

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Chemopreventive effect of carvacrol on 1,2-dimethylhydrazine induced experimental colon carcinogenesis

Abstract: The results of this study suggest that carvacrol at a dose of 40 mg/kg b.wt showed a significant beneficial effect against chemically-induced colon carcinogenesis in rats.

Cited by 38 publications

References 0 publications

Bone Marrow Cell Therapy on 1,2-Dimethylhydrazine (DMH)-Induced Colon Cancer in Rats

Bone Marrow Cell Therapy on 1,2-Dimethylhydrazine (DMH)-Induced Colon Cancer in Rats

Antitumor Effects of Carvacrol and Thymol: A Systematic Review

Chemoprevention of Colorectal Cancer by Dietary Compounds

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