Chemopreventive efficacy of a betel leaf extract against benzo[a]pyrene-induced forestomach tumors in mice

Bhide, S. V.; Zariwala, Maimoona B; Amonkar, A.J.; Azuine, Magnus A.

doi:10.1016/0378-8741(91)90039-g

Cited by 61 publications

(36 citation statements)

References 22 publications

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“…Although most Taiwanese people consume a combination of betel nut, piper betle influorescence and lime paste, some use betel nut wrapped in betel leaf. Betel leaf contains eugenol and hydroxycavicol, which are thought to be antimutagenic and anticarcinogenic (Bhide et al, 1991;Ko et al, 1995). The latter workers have reported that chewing betel nut wrapped in betel leaf seemed to be less of an oral cancer risk than the combination of betel nut, piper betle influorescence and lime paste.…”

Section: Discussionmentioning

confidence: 99%

Risk of betel chewing for oesophageal cancer in Taiwan

Lee

et al. 2001

Br J Cancer

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Among 104 cases of squamous-cell oesophageal carcinoma patients and 277 controls in Taiwan, after adjusting for cigarette smoking, alcohol consumption, and other confounders, we found that subjects who chewed from 1 to 495 betel-year and more than 495 betel-years (about 20 betel quid per day for 20 years) had 3.6-fold (95% Cl = 1.3–10.1) and 9.2-fold risk (95% Cl = 1.8–46.7), respectively, of developing oesophageal cancer, compared to those who did not chew betel. © 2001 Cancer Research Campaign http://www.bjcancer.com

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Section: Discussionmentioning

confidence: 99%

Risk of betel chewing for oesophageal cancer in Taiwan

Lee

et al. 2001

Br J Cancer

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“…Thus there was no correlation between the results of the DNA biosynthesis experiment and those of the anticarcinogenicity assays done by Azuine et al (1991), Athar et al (1989) and Soudamini et al (1991, wherein all the test agents, with the exception of eugenol, prevented DMBA induced skin tumours. This lack of correlation could be because the dose of test compound used was not appropriate or else repetitive treatment was needed to exert any protective effect, as is seen in the anticarcinogenicity study done by Azuine et al (1991).…”

Section: Discussionmentioning

confidence: 81%

Studies on possible protective effect of plant derived phenols and the vitamin precursors—β‐Carotene and α‐tocopherol on 7,12 dimethylbenz (a) anthracene induced tumour initiation events

Moushumi

Sumati

1994

Phytotherapy Research

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Our earlier experiments have shown that the plant phenols-hydroxychavicol, eugenol, catechin, curcumin, and the vitamins--6-carotene and a-tocopherol-are potent inhibitors of polycyclic aromatic hydrocarbon (PAH) induced mutagenesis and carcinogenesis. In an attempt to elucidate their mode of action, we studied their effect on mouse skin DNA synthesis following 7,12 dimethylbenzanthracene (DMBA) treatment and 'H-7,12 dimethylbenzanthracene-DNA interaction in u h o (in the presence of mouse skin S9). With the exception of eugenol, all the phenols and vitamins tested inhibited 'H-DMBA-DNA interaction in uilro. In the DNA biosynthesis assay, of the chemopreventive agents tested only b-carotene effectively modulated DMBA suppressed DNA synthesis in the mouse skin. Our results indicate that the assay of DNA biosynthesis is not of predictive value with respect to the chemopreventive effect of a chemical, while assay of carcinogen-DNA interaction shows correlation between the chemopreventive property and the inhibition of the interaction of carcinogen with DNA.

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“…The betel leaves act as breath-freshener and are used in the Indian system of medicine and health and include medicinal properties such as digestive, antacid, decongestant, carminative, stimulant, antipyretic, anti-inflammatory, anti-allergic, anti-septic, hepatoprotective, radio-protective, anti-fungal, anti-platelet, anti-fertility, nematocidal and anti-oxidant [7][8][9][10][11][12][13][14][15][16]. The chief constituent of the leaves is a volatile oil which contains phenols, betel-phenol; chavibetol and chavicol; cadinene and hydroxychavicol, which have been ascribed to possess anti-oxidant and anti-carcinogenic activities [8,17]. This crop is claimed to have hundreds of landraces broadly grouped into three types, Bangla, Kapoori and others [18,19].…”

Section: Introductionmentioning

confidence: 99%