Chemopreventive Potential of an Ethyl Acetate Fraction from Curcuma Longa is Associated with Upregulation of p57^kip2and Rad9 in the PC-3M Prostate Cancer Cell Line

Combinatorial cytotoxic effects of Curcuma longa and Zingiber officinale on the PC-3M prostate cancer cell line

“…Recently, we reported that C. longa extract showed not only inhibition of the colony-forming ability of PC-3M cells but also up-regulated the cell cycle genes P57 KIP2 and Rad9 and reduced the migration and invasive ability of prostate cancer cells (25). Using proteomic profiling, we have further reported that this extract induced 29 differentially-expressed proteins, among which 13 were down-regulated and 16 up-regulated (26).…”

“…Accordingly, we have attempted to test some medicinal plant extracts from Generally Recognized as Safe (GRAS) plants that may be useful in the prevention and treatment of cancer using a highly metastatic (PC-3M) prostate cancer cell line as model system (see Figure 1). We recently reported that Curcuma longa extract not only inhibited the colony-forming ability of PC-3M cells but also up-regulated cell cycle genes P57 KIP2 and Rad9 and reduced the migration and invasive ability of prostate cancer cells (25). Using proteomic profiling, we further reported that this extract induced 29 differentially-expressed proteins, among which 13 were down-regulated and 16 up-regulated (26).…”

Bioassay-Guided Isolation and HPLC Quantification of Antiproliferative Metabolites from Stahlianthus thorelii

“…Many species in this family have already been studied for their phytochemicals and bioactivities, which display significant anticancer, antimicrobial, anti-inflammation bioactivities [1]. The potential of anticancer activities of the species in the Zingiberaceae family have been were investigated through many studies [2][3][4][5][6][7][8][9]. Extracts of eight species of Zingiberaceae including Amommum cardamomum, Curcuma longa, C. mangga, C. xanthorrhiza, Kaempferia pandurata, Zingiber officinale, Z. aromaticum, and Z. cassumunar were found to inhibit the growth of MCF-7 and HT-29 cancer cell lines [2].…”

“…Extracts of eight species of Zingiberaceae including Amommum cardamomum, Curcuma longa, C. mangga, C. xanthorrhiza, Kaempferia pandurata, Zingiber officinale, Z. aromaticum, and Z. cassumunar were found to inhibit the growth of MCF-7 and HT-29 cancer cell lines [2]. In 2015, an ethanolic extract of C. longa was reported to possess the antiproliferative and proapoptotic effects on murine melanoma B164A5 [3] and prostate cancer cell lines [4]. In addition, Z. officinale [5,6], K. pandurata [7], and Alpinia galangal [8] were mentioned to have the promising cytotoxicity against several cancer cell lines.…”