Chemopreventive potential of epigallocatechin gallate and genistein: evidence from epidemiological and laboratory studies

Park, Ock Jin; Surh, Young‐Joon

doi:10.1016/j.toxlet.2003.06.001

Cited by 184 publications

(116 citation statements)

References 91 publications

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“…Antigenotoxic effect of genistein and also its opposite effect are discussed in excellent reviews by POLKOWSKI and MAZUREK (2000), LI (2002) andSURH (2004), altogether with the explanation of its effects at molecular and cellular levels.…”

Section: Discussionmentioning

confidence: 99%

“…These effects on the molecular and cellular levels are summarised in POLKOWSKI and MAZUREK (2000); LI (2002, 2004); PARK and SURH (2004). On the cellular level, it induces cellular differentiation, alters cell cycle progression, inhibits cell proliferation, and induces apoptosis.…”

Section: Antimutagenic Effect Of Genisteinmentioning

confidence: 99%

“…An association between high soya intake and lower incidence of endometrium cancer were also described (GOODMAN et al 1997). Epidemiologic data are summarised in PARK and SURH (2004). In a study of LAMARTINIERE et al (2002), genistein was confirmed as an agent protecting animals against experimentally induced mammary and prostate cancers.…”

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confidence: 98%

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Antimutagenic effect of genistein

Polívková¹,

Langova²,

Smerak³

et al. 2006

Czech J. Food Sci.

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POLÍVKOVÁ Z., LANGOVÁ M., ŠMERÁK P., BÁRTOVÁ B., BÁRTA I.: Antimutagenic effect of genistein. Czech J. Food Sci., 24: 119-126.A great variety of health benefits including the protection against breast and prostate cancers has been attributed to the soya consumption, because of the presence of soy beans isoflavones, genistein, and others. We investigated the antigenotoxic effect of genistein on the genotoxicity of three mutagens and carcinogens -aflatoxine B 1 (AFB 1 ), 2-amino-3-methylimidazo [4,5-f ]quinoline (IQ), and N-nitroso-N-methylurea (MNU), using the Ames bacterial mutagenicity test and the micronucleus test. In the Ames test on Salmonella typhimurium, a significant antimutagenic effect was determined against the indirect mutagen AFB 1 in two strains, TA98 and TA100. However, the effect on the IQ indirect mutagenicity was more pronounced in the test with TA98 than with TA100. The mutagenicity of the direct mutagen MNU was suppressed by genistein only at its highest concentration used (300 µg/plate). The protective effect of genistein against all three mutagens was proved in the micronucleus test as the treatment of mice with the combinations of genistein and mutagens resulted in a significant reduction of the number of micronuclei in comparison with the number of micronuclei induced by the individual mutagens alone.

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Section: Discussionmentioning

confidence: 99%

Section: Antimutagenic Effect Of Genisteinmentioning

confidence: 99%

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Antimutagenic effect of genistein

Polívková¹,

Langova²,

Smerak³

et al. 2006

Czech J. Food Sci.

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“…15 Despite the large number of flavonoids, studies have focused only on a select few. The flavonoids most intensely studied in PCa to date are the soy isoflavones (genestein/daidzein), 16,17 the green tea catechins (EGCGepigallocatechin-3-gallate) 18,19 and the milk thistle flavonones (silibinin/silymarin). 20,21 Little is known of the biological effect of most other flavonoids.…”

Section: Introductionmentioning

confidence: 99%

Novel antiproliferative flavonoids induce cell cycle arrest in human prostate cancer cell lines

Haddad

Venkateswaran

Viswanathan

et al. 2005

Prostate Cancer Prostatic Dis

152

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Epidemiologic studies have demonstrated an inverse association between flavonoid intake and prostate cancer (PCa) risk. The East Asian diet is very high in flavonoids and, correspondingly, men in China and Japan have the lowest incidence of PCa worldwide. There are thousands of different naturally occurring and synthetic flavonoids. However, only a few have been studied in PCa. Our aim was to identify novel flavonoids with antiproliferative effect in PCa cell lines, as well as determine their effects on cell cycle. We have screened a representative subgroup of 26 flavonoids for antiproliferative effect on the human PCa (LNCaP and PC3), breast cancer (MCF-7), and normal prostate stromal cell lines (PrSC). Using a fluorescence-based cell proliferation assay (Cyquant), we have identified five flavonoids, including the novel compounds 2,2 0 -dihydroxychalcone and fisetin, with antiproliferative and cell cycle arresting properties in human PCa in vitro. Most of the flavonoids tested exerted antiproliferative effect at lower doses in the PCa cell lines compared to the non-PCa cells. Flow cytometry was used as a means to determine the effects on cell cycle. PC3 cells were arrested in G2/M phase by flavonoids. LNCaP cells demonstrated different cell cycle profiles. Further studies are warranted to determine the molecular mechanism of action of 2,2 0 -DHC and fisetin in PCa, and to establish their effectiveness in vivo.

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“…5 Their effects on proliferation and differentiation have been studied both in cancerous and noncancerous cell lines. 1,6,7 However, there is little information about their effects on adipocytes. 6,8,9 Few studies have focused on the action of procyanidins, an oligomeric class of flavonoids, in the adipose cell 10 or on the relationship between procyanidins and the adipose differentiation process.…”

Section: Introductionmentioning

confidence: 99%

Grape-seed derived procyanidins interfere with adipogenesis of 3T3-L1 cells at the onset of differentiation

et al. 2005

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OBJECTIVE: Our group's previous results on the effects of a grape seed procyanidin extract (GSPE) on adipose metabolism showed that peroxisome proliferator-activated receptor-g (PPARg) plays a central role in the lipolytic effects of GSPE on adipocytes. Since PPARg2 is a main regulator of the differentiation process of adipocytes, we investigated whether GSPE affects the adipogenesis of 3T3-L1 cells. DESIGN: We performed a time point screening by treating 3T3-L1 cells with GSPE during the differentiation process for 24 h. MEASUREMENTS: Differentiation markers and differential gene expression due to GSPE treatment (using the microarray technique). RESULTS: Twenty four hour-GSPE treatment at the onset of differentiation reduces adipose-specific markers and maintains the expression of preadipocyte marker preadipocyte factor-1 (Pref-1) significantly elevated. These effects were not found in other time points. Microarray analysis of gene expression after GSPE treatment at the early stage of differentiation showed a modified gene expression profile in which cell cycle and growth-related genes were downregulated by GSPE. CONCLUSION: These results suggest that GSPE affects adipogenesis, mainly at the induction of differentiation, and that procyanidins may have a new role in which they impede the formation of adipose cells.

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Chemopreventive potential of epigallocatechin gallate and genistein: evidence from epidemiological and laboratory studies

Cited by 184 publications

References 91 publications

Antimutagenic effect of genistein

Antimutagenic effect of genistein

Novel antiproliferative flavonoids induce cell cycle arrest in human prostate cancer cell lines

Grape-seed derived procyanidins interfere with adipogenesis of 3T3-L1 cells at the onset of differentiation

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