Chemoprotective effects of carnosine against genotoxicity induced by cyclophosphamide in mice bone marrow cells

Naghshvar, Farshad; Abianeh, Shahrzad Mohseni; Ahmadashrafi, Saeb; Hosseinimehr, Seyed Jalal

doi:10.1002/cbf.2834

Cited by 9 publications

(10 citation statements)

References 32 publications

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“…These studies established that carnosine exerts protective effects mainly through antioxidant activity. We recently showed that the administration of carnosine to mice before cyclophosphamide significantly reduced genotoxicity in mouse bone marrow cells (Naghshvar et al ., ). Carnosine was used to treat dyslexia (400 mg daily) and autistic spectrum disorders (800 mg daily) in children without causing any undesirable side effects (Chez et al ., ; Kairaluoma et al ., ).…”

Section: Discussionmentioning

confidence: 97%

“…These doses of carnosine were selected according to our previous study (Naghshvar et al ., ). The mice were irradiated with a total dose of 2 Gy gamma rays.…”

Section: Methodsmentioning

confidence: 97%

“…Carnosine prevents the detoxifying enzymes Cu‐ and Zn‐superoxide dismutase from hydrogen peroxide (H 2 O 2) and the hydroxyl radical (•OH) (Choi et al ., ; Kang et al ., ). Several studies have reported that administering carnosine prevented toxicity induced by several drugs including bleomycin‐induced lung injury, cisplatin‐induced nephrotoxicity, acetaminophen‐induced hepatotoxicity and cyclophosphamide‐induced genotoxicity (Cuzzocrea et al ., ; Fouad et al ., ; Yan et al ., ; Naghshvar et al ., ). In addition, we recently showed that carnosine significantly reduced DNA damage induced by cyclophosphamide in mouse bone marrow (Naghshvar et al ., ).…”

Section: Introductionmentioning

confidence: 97%

“…Several studies have reported that administering carnosine prevented toxicity induced by several drugs including bleomycin‐induced lung injury, cisplatin‐induced nephrotoxicity, acetaminophen‐induced hepatotoxicity and cyclophosphamide‐induced genotoxicity (Cuzzocrea et al ., ; Fouad et al ., ; Yan et al ., ; Naghshvar et al ., ). In addition, we recently showed that carnosine significantly reduced DNA damage induced by cyclophosphamide in mouse bone marrow (Naghshvar et al ., ). In this study, we have used the TUNEL test and histopathology to assess radioprotective effects of carnosine against testicular injury in mice exposed to gamma radiation.…”

Section: Introductionmentioning

confidence: 97%

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Carnosine mitigates apoptosis and protects testicular seminiferous tubules from gamma-radiation-induced injury in mice

et al. 2013

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This study investigated the radioprotective effects of a naturally occurring dipeptide, carnosine, on testicular damage. Carnosine was administered (10, 50 and 100 mg kg(-1) body weight) to male mice via intraperitoneal injection for 4 days prior to gamma irradiation (2 Gy). Apoptosis with the TUNEL assay and histopathological parameters were evaluated 12-h and 14-day post-irradiation. Pre-treatment with carnosine before irradiation significantly reduced the frequency of TUNEL-positive cells induced by radiation treatment at all doses by reduction factors of 1.8, 2.47 and 2.23 for carnosine at 10, 50 and 100 mg kg(-1) bw, respectively, unlike that observed in the radiation alone group. Exposure to ionising radiation decreased sperm count and reduced the height and diameter of seminiferous epithelial tubules. Pre-treatment with all doses of carnosine significantly augmented seminiferous epithelial height and tubule diameter and also increased the number of germinal cells in comparison to the group treated with radiation only. These results indicate that carnosine prevents testicular dysfunction induced by gamma-irradiation via an anti-apoptotic effect; this restoration of proper testicular function ultimately leads to the recovery of spermatogenesis.

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Section: Discussionmentioning

confidence: 97%

“…These doses of carnosine were selected according to our previous study (Naghshvar et al ., ). The mice were irradiated with a total dose of 2 Gy gamma rays.…”

Section: Methodsmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 97%

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Carnosine mitigates apoptosis and protects testicular seminiferous tubules from gamma-radiation-induced injury in mice

et al. 2013

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“…In addition, the number of PCEs among 500 total erythrocytes (PCE + NCE) per animal was recorded to evaluate bone marrow toxicity. 29,30 To calculate the protective (anti-mutagenic) rate of each honey against CP) mutagenic effect, as reflected by induction of micronucleus formation the following equation was applied. 4,30 100% (MN) in (CP + honey) groups × 100% (MN) in (CP) groups…”

Section: Mn Assaymentioning

confidence: 99%

Investigation of role magnetized water used in supplementary feeding for honeybees to modulate the genotoxic side effects induced by cyclophosphamide in mice bone marrow cells

Farhan¹,

Chechan

Alkinani

2017

J. contemp. med. sci.

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Objective To evaluate the possible protective role of honey formed through innovative way by using magnetized water instead of tab water in supplementary feeding for bees (HW) and compared with two honey types formed by two different feeding solutions; sugar syrup (HS) and nectar of flowers (HF) against cyclophosphamide (CP) genotoxicity in mice bone marrow cells, by using the micronucleus assay (MN). Methods Mice were divided into 8 groups from 3 animals each. G1 as control. G2 were exposed to CP (40 mg/kg), G3, G4, and G5 received two dose of three types of honey at doses (300, 600 mg/kg) respectively. The other groups G6, G7 and G8 were supplemented with three types honey (300 mg/kg) in three different experimental protocols, as pre 2 h, post 2 h, and concomitant treatment for 7 and 14 days. Results Examination and analysis of MN showed no mutagenic effect of three types honey per se doses, especially in low dose (300 mg/kg). Meanwhile, CP induced a significant (P < 0.01) increase in MN frequency. While dual treatment with groups of honey HW caused a significant reduction in MN induced by CP in bone marrow cells in a time-dependant manner. Also, the results confirmed the protective efficacy of HW group and/or HF group as compared with HS group, against CP-toxicity. Conclusion Our study suggests using magnetized water in supplementary feeding of bee, that could give the honey protective effect against genotoxicity induced by CP, it is also fosters antioxidant activity of honey constituents. Therefore, honey HW can be used as an adjuvant with chemotherapeutic agents for minimizing the genotoxic side effects of the anticancer drug CP.

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Carnosine and advanced glycation end products: a systematic review

Ghodsi

Kheirouri

2018

Amino Acids

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Advanced glycation end products (AGEs) are a cluster of heterogeneous molecules that are generated in a non-enzymatic reaction by the binding of sugars with amino groups of DNA, lipids and proteins. Carnosine is a naturally occurring dipeptide with antioxidant activity, which inhibits protein carbonylation and glycoxidation. This systematic review searched international sources for all published and unpublished original research in English from any year up to the end of April 2018. An electronic search of PubMed, Scopus and Google Scholar was conducted. 187 articles were initially found and 133 articles were selected after excluding duplicated data. Review articles, studies based on the components of carnosine and studies that were about the effects of carnosine on AGEs-induced changes were excluded. In total, 36 studies met the inclusion criteria. This included 19 in vitro studies, 15 animal studies and two human studies. All but two of the studies indicated that carnosine can prevent the formation of AGEs. The findings of this review indicating that carnosine has anti-glycating properties, and may hinder the formation of protein carbonyls and the cross-links induced by reduced sugars; however, there were few human studies. The mechanism by which carnosine prevents the formation of AGEs needs further investigation.

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Chemoprotective effects of carnosine against genotoxicity induced by cyclophosphamide in mice bone marrow cells

Cited by 9 publications

References 32 publications

Carnosine mitigates apoptosis and protects testicular seminiferous tubules from gamma-radiation-induced injury in mice

Carnosine mitigates apoptosis and protects testicular seminiferous tubules from gamma-radiation-induced injury in mice

Investigation of role magnetized water used in supplementary feeding for honeybees to modulate the genotoxic side effects induced by cyclophosphamide in mice bone marrow cells

Carnosine and advanced glycation end products: a systematic review

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