Chemoprotective properties of rooibos (Aspalathus linearis), honeybush (Cyclopia intermedia) herbal and green and black (Camellia sinensis) teas against cancer promotion induced by fumonisin B1 in rat liver

Marnewick, Jeanine L.; Westhuizen, Francois H. van der; Joubert, Elizabeth; Swanevelder, Sonja; Gelderblom, W.C.A.

doi:10.1016/j.fct.2008.11.004

Cited by 104 publications

(75 citation statements)

References 62 publications

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“…In our study the activity of this enzyme was not determined, but that of another antioxidant enzyme, glutathione peroxidase (GPx) was. According to Kang and Alexander (1996), kidney cells do not react to FB 1 with a GPx activity alteration in vitro, but Marnewick et al (2009) reported increased GPx activity induced by an FB 1 dose of 250 mg/kg feed for 21 days in rats. Our short and not drastically high exposure did not affect the hepatic tissue activity of GPx.…”

Section: Reduced Glutathione and Glutathione Peroxidasementioning

confidence: 99%

Acute hepatic effects of low-dose fumonisin B1 in rats

Szabó

Szabó-Fodor

Fébel

et al. 2016

Acta Veterinaria Hungarica

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Adult male Wistar rats were enrolled in a study to test the acute hepatic effects of 50 mg/kg fumonisin B 1 in feed for 5 days. Fumonisin B 1 depressed growth and feed intake, and absolute and relative liver weight showed a significant increase. The proportions of C17:0, C18:3 n3, C22:5 n3 and C22:6 n3 fatty acids decreased in the hepatic phospholipid fraction. All proportional decreases modified the hepatocellular membrane lipids into a more rigid state. The fatty acid profile modifications were partly compensated for by endogenous glutathione (preventing the formation of conjugated dienes and trienes as initial phase lipid peroxidation indicators), while the enzymatic antioxidant defence system (glutathione peroxidase) was unaltered. In contrast, hepatic malondialdehyde, the cytotoxic product of end-phase lipid peroxidation showed a concentration increase even after 5 days of feeding. The results indicate a rather strong and rapid hepatic effect of FB 1 , immediately impairing membrane phospholipids, even before the enzymatic antioxidant defence is activated.Key words: Fumonisin B 1 , rat, hepatocellular membrane, fatty acids, oxidative stress, antioxidants Fumonisins are cancer-inducing metabolites of Fusarium proliferatum and Fusarium verticillioides. They have a long-chain hydrocarbon unit (mimicking to a certain extent cellular sphingosine and sphinganine), which plays a determinant role in their cell-membrane-associated toxicity. From the fumonisin group, fumonisin B 1 (FB 1 ) shows strong toxic effects and has been reported to promote hepatic tumour in rats. Fumonisin B 1 , the most abundant of the numerous fumonisin analogues, was classified by the IARC as a Group 2B carcinogen (possibly carcinogenic in humans; IARC, 2002).

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Section: Reduced Glutathione and Glutathione Peroxidasementioning

confidence: 99%

Acute hepatic effects of low-dose fumonisin B1 in rats

Szabó

Szabó-Fodor

Fébel

et al. 2016

Acta Veterinaria Hungarica

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“…The rats were maintained in a temperature controlled room of 22-25°C, humidity of 45-55%, 15-20 air changes per hour and on a 12 hour light/dark cycle and rats have free access to standard rat chow. The rats were treated by supplementing their diets with 2 ml red palm oil (Aboua et al, 2009) and/ or 2% rooibos tea extracts (Marnewick et al, 2009) for 7 weeks. The fermented rooibos was supplied by Rooibos Ltd (Clanwilliam, South Africa) and the red palm oil used was Carotino palm fruit oil from Malaysia.…”

Section: Preparation Of Rooibos Tea Extractmentioning

confidence: 99%

Effects of red palm oil and rooibos on sperm motility parameters in streptozotocininduced diabetic rats

Ayeleso¹,

Oguntibeju²,

Aboua³

et al. 2014

Afr. J. Trad. Compl. Alt. Med.

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Background: Diabetes mellitus characterized by hyperglycaemia could affect sperm quality as a result of increased oxidative stress. This study was performed to investigate the effects of red palm oil (RPO), aqueous rooibos tea extracts (RTE) as well as their combination (RPO + RTE) on sperm motility parameters in streptozotocin-induced diabetic rats. Materials and Methods: Diabetes was induced by a single administration of streptozotocin (50 mg/kg) and the rats were treated with red palm oil (2 ml/day) and / or aqueous rooibos tea extract (2%) for 7 weeks. Sperm motility parameters were measured using Computer Assisted Sperm Analyzer (CASA). Results: Hyperglycaemia negatively affected the sperm progressive motility significantly at p<0.05. There was a significant decrease (p<0.05) in sperm linearity (LIN) in the diabetic group when compared with the normal control group. RPO supplemented diabetic rats exhibited increased progressive sperm motility, sperm linearity (LIN) and wobble (WOB). Significant decreases (p<0.05) in straight line velocity (VSL) and average path velocity (VAP) of the sperms were observed in all the diabetic groups when compared to the control group. Significant (p<0.05) elevated levels of WOB and LIN were observed following RTE treatment and co-administration with RPO respectively. Conclusion:The present study suggests that red palm oil and / or rooibos administration exhibited no adverse effects on sperm motility parameters but rather showed some beneficial effects.

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“…While fresh leaves of rooibos contain polyphenols as flavanols, dihydrochalcones and aspalathin, processed leaves and stem include benzoic and cinnamic acid (Muller et al, 2016). Additionally, anti-cancer properties of rooibos demonstrated in rat liver, oesophagus, and skin carcinogenesis models, have been attributed to their polyphenolic compounds (Marnewick et al, 2009;Sissing et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Investigating the Physicochemical Properties and in Vitro Bioaccessibility of Phenolics and Antioxidant Capacity of Rooibos Herbal Tea Beverage

Suna¹

2017

GIDA

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In this research, production of novel beverages was planned and evaluation of physicochemical properties, total phenolics, antioxidant capacity, and bioaccessibility of products were aimed. Accordingly, 1% rooibos extract, citric and ascorbic acids, natural lemon flavor were added all types of beverages. Sucrose, agave, aspartame and acesulfame-K were respectively added to the beverages coded as RS, RA and RSW. Mixtures were plate filtered, filled into 200 mL glass bottles and pasteurized at 98 °C for 15 min. Total phenolic content and antioxidant capacity with FRAP, CUPRAC and DPPH assays were determined in beverages and rooibos extract. An in vitro model simulating gastrointestinal (GI) digestion system was also adapted to assess the bioaccessibility of phenolics and antioxidant capacity. Total phenolics were determined more bioaccessible in RS (405.02±4.57 mg GAE/100 mL) while the highest bioaccessibilities of antioxidant capacity was obtained from RA with CUPRAC (7.19%) and FRAP (1.82%) resulting with the highest functionality.

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Chemoprotective properties of rooibos (Aspalathus linearis), honeybush (Cyclopia intermedia) herbal and green and black (Camellia sinensis) teas against cancer promotion induced by fumonisin B1 in rat liver

Cited by 104 publications

References 62 publications

Acute hepatic effects of low-dose fumonisin B1 in rats

Acute hepatic effects of low-dose fumonisin B1 in rats

Effects of red palm oil and rooibos on sperm motility parameters in streptozotocininduced diabetic rats

Investigating the Physicochemical Properties and in Vitro Bioaccessibility of Phenolics and Antioxidant Capacity of Rooibos Herbal Tea Beverage

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