Chemoresistance factors in non-small cell lung cancer

Шевченко, А. І.; Колесник, А. П.; Kadzhoian, A. V.; Кuzmenko, V. А.

doi:10.14739/2310-1237.2016.1.71945

Cited by 2 publications

(2 citation statements)

References 27 publications

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“…За даними [2], відомо декілька внутрішньоклітинних комплексів, що здійснюють репарацію ДНК: 1) комплекс видалення нуклеотидів (NER); 2) комплекс гомологічної рекомбінації; 3) комплекс негомологічного з'єднання кінців (тип генетичної рекомбінації, що використовується клітинами для відновлення дволанцюгових розривів ДНК); 4) комплекс ВER, здатний розпізнавати точкові пошкодження нуклеотидів і усувати їх за допомогою ферментів глікозилаз), 5) комплекс репарації невідповідності (MMR). На відміну від ВER, комплекс видалення нуклеотидів NER розпізнає об'ємні пошкодження зв'язків між ланцюгами ДНК і здійснює висікання пошкодженого сегмента ДНК [2]. Більшість внутрішньоланцюгових поперечних з'єднань вилучаються системою NER шляхом висікання пошкоджених нуклеотидів і синтезу ДНК для відновлення генетичної цілісності, інші пошкодження відновлюються комплексними механізмами [13].…”

Section: посилення процесів репарації днкunclassified

“…Ці механізми є дуже складними і недостатньо вивченими. Наприклад, комплекс видалення нуклеотидів NER являє собою цілу систему, до якої входять декілька основних складових: XPA-XPG, ERCC1, білок реплікації A (RPA), Rad23A, ДНК полімерази δ і ε та ДНК-лігаза [2]. Ключове значення в комплексі NER належить білку ERCC1 через його здатність відновлювати поперечні зв'язки і подвійні розриви ланцюгів ДНК, усуваючи індуковані цисплатином пошкодження ДНК [2].…”

Section: посилення процесів репарації днкunclassified

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Peculiarities of interaction of malignant cells and tumors with chemotherapeutic nanocomposite remedies

Turanska,

Krupska,

Turov

et al. 2023

Poverhn.

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The purpose of the review is to find, generalize and analyze scientific data related to the specifics of the interaction of chemotherapeutic official drugs and nanocomposites based on them with malignant cells and tumors, primarily characterized by the emergence of drug resistance, the determination of promising directions and ways to overcome it, and the creation of new effective nanocomposite remedies for use in antitumor chemotherapy. The given data indicate the relevance of the topic. Targeted studies of the resistance of malignant cells and neoplasms to chemotherapeutic drugs have been carried out since the 1990s. The majority of works were performed according to the methodology, that involves the traditional use of chemotherapeutic drugs. In these works, the principle of the multifactorial nature of resistance was determined, the processes and mechanisms of its implementation were studied, related to the reduction of the accumulation of the chemotherapeutic drug in cells, the increase in the activity of detoxification systems, the strengthening of DNA repair processes, the reduction of apoptosis, and autophagy. A number of promising substances and influencing factors contributing to overcoming of resistance have been identified. However, the discovered ways to overcome the resistance of malignant cells and neoplasms to the corresponding drugs are at the stages of laboratory, preclinical, or, in the best case, clinical research. At the same time, it is not excluded that the use of the latest highly effective chemotherapeutic drugs will lead to the emergence of new mechanisms of resistance. Thus, at this time the results of research on the traditional use of chemotherapeutic drugs constitute a significant fundamental and practically important development regarding the determination of mechanisms of drug resistance, however, the problem of its medicinal overcoming remains far from being solved, and the used approaches give the impression of dead ends. With the development of nanotechnology, new scientific directions have been initiated and a significant amount of researches has been carried out, devoted to the creation and search for promising applications in oncology of nanocomposites based on bioinert, biocompatible and bioactive nanoparticle materials and modern chemotherapeutic drugs. It should be emphasized that all these works contain data indicating the advantages of introducing nanocomposite drugs into clinical practice, compared to the use of chemotherapeutic drugs in traditional forms. Against this background, purposeful researches are distinguished carried out by scientists of O.O. Chuiko Institute of Surface Chemistry of National Academy of Sciences of Ukraine and R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of National Academy of Sciences of Ukraine in the field of creation of modern polyfunctional nanocomposite chemotherapeutic agents for use in antitumor therapy, capable of overcoming drug resistance of malignant cells and neoplasms. So, at O.O. Chuiko Institute of Surface Chemistry of National Academy of Sciences of Ukraine for the first time magnetic fluids were synthesized containing antitumor drugs cisplatin, doxorubicin, gemcitabine, corresponding antibodies, their physicochemical properties were studied, and parameters for standardization were determined. At R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of National Academy of Sciences of Ukraine the antitumor properties of magnetic fluids were studied. On the basis of magnetic fluid with cisplatin, the first native magnetosensitive oncological drug "Feroplat" has been proposed, which has no analogues in the world. Feroplat is a standardized tool for increasing the effectiveness of chemotherapy and overcoming drug resistance of malignant neoplasms, intended for the delivery of cytostatics directly to the tumor tissue. This ensures its maximum entry into the cells and helps to increase the therapeutic effect. In order to introduce "Feroplat" into production and clinical practice, its preclinical tests were successfully performed. The analysis of the given data indicates the priority of works in the field of creation of new nanocomposite chemotherapeutic drugs for use in antitumor therapy, capable of overcoming drug resistance of malignant cells and neoplasms. The facts of overcoming the drug resistance of malignant neoplasms to cisplatin with the new native oncological drug "Feroplat", as well as high indicators of cytotoxic / cytostatic activity of nanobiocomposites based on saline solution, magnetite and cisplatin, doxorubicin, gemcitabine, etc., may indicate the fundamental need to change approaches to the use of modern antitumor chemotherapeutic agents – by replacing their traditional molecular forms with appropriate nanocomposite forms.

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Section: посилення процесів репарації днкunclassified

Peculiarities of interaction of malignant cells and tumors with chemotherapeutic nanocomposite remedies

Turanska,

Krupska,

Turov

et al. 2023

Poverhn.

View full text Add to dashboard Cite

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Increase in efficiency of chemotherapeutic drugs: physico-chemical factor

Turanska,

Krupska,

Turov

et al. 2024

Him. Fiz. Tehnol. Poverhni

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With the development of nanotechnology, new scientific directions have been initiated and a significant amount of researches has been carried out, dedicated to the creation and search for promising applications in medicine, in particular, oncology, of nanocomposites based on bioinert, biocompatible and bioactive nanoparticle materials and modern chemotherapeutic drugs with different mechanisms of action. These works contain data indicating the advantages to introduce nanocomposite drugs into clinical practice, compared to the traditional use of chemotherapeutic drugs. The research results confirm the priority of works in the field of creation of new nanocomposite chemotherapeutic drugs for use in antitumor therapy and overcoming of drug resistance of malignant cells and neoplasms. The purpose of the review is to generalize and analyze the authors’ experimental works performed at Chuiko Institute of Surface Chemistry of National Academy of Sciences of Ukraine, concerning the specifics of the effect of chemotherapeutic drugs with different mechanisms of action and related nanocomposites, on cellular systems and tumors. Such data are relevant to determine promising directions and ways of creation of new effective nanocomposite drugs for use, in particular, in antitumor chemotherapy. At Chuiko Institute of Surface Chemistry of National Academy of Sciences of Ukraine, using the chemical engineering method, magnetically sensitive core-shell nanocomposites were synthesized with a multi-level hierarchical nanoarchitecture capable of performing a complex of diagnostic and therapeutic functions with various mechanisms of action, characteristic of medico-biological nanorobots. Their use makes it possible to implement the principle of targeted delivery of antitumor drugs, to carry out real-time local therapy by various methods and MRI diagnosis of the disease, to realize the synergy of treatment with antitumor drugs of different mechanisms of action, to reduce the toxic side effects of oncological drugs on the body. The combination of the above features of nanocomposites, as well as their role in overcoming the drug resistance of cells of malignant neoplasms to cisplatin, testify to the perspective of creation and research of nanocomposite drugs in solving the problem of increase in the efficiency of chemotherapy.

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Chemoresistance factors in non-small cell lung cancer

Cited by 2 publications

References 27 publications

Peculiarities of interaction of malignant cells and tumors with chemotherapeutic nanocomposite remedies

Peculiarities of interaction of malignant cells and tumors with chemotherapeutic nanocomposite remedies

Increase in efficiency of chemotherapeutic drugs: physico-chemical factor

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