Carbohydrates are a complex class of essential biomolecules that can be considered as the dark matter of the biological universe as they are greatly understudied yet omnipresent in all kingdoms of life and vital to fully understand biological processes. The structurally diverse carbohydrates are present both on the cell surface and inside cells. They decorate the cell surface to form the so-called glycocalyx, a dense and complex layer of carbohydrates unique for every type of cell or organism, and as such are key to many important biological recognition events by interacting with carbohydrate-binding proteins. Carbohydrate-protein interactions play an important role in various biological events occurring at the cell surface, such as bacterial and viral infections [1,2], cancer metastasis [3,4], and immune response [4]. The study of the interactions between carbohydrates and other biomolecules at biological surfaces