Chemosensory Event-Related Potentials and Power Spectrum Could Be a Possible Biomarker in 3M Syndrome Infants?

Invitto, Sara; Grasso, Alberto; Lofrumento, Dario Domenico; Ciccarese, Vincenzo; Paladini, A; Paladini, Pasquale; Marulli, Raffaella; Pascalis, Vilfredo De; Polsinelli, Matteo; Placidi, Giuseppe

doi:10.3390/brainsci10040201

Cited by 4 publications

(4 citation statements)

References 45 publications

(70 reference statements)

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“…The odorants stimulation had a duration of 1 s, with an interstimulus of 20 sec. Scents were administered via an olfactometer, as in our previous studies [ 17 , 28 , 33 , 39 , 41 ], in two vials, with 20 μL of cinnamaldehyde/eucalyptus provided in 10 mL of Vaseline oil, and both odorous solutions were presented in 20 mL transparent glass vials.…”

Section: Methodsmentioning

confidence: 99%

“…Aside from criticism, various studies identify CSERPs as biomarkers of olfactory deficits or as biomarkers in neurodegenerative disorders, and it is relevant to see how, despite the different techniques used (e.g., classical component analysis [ 13 , 15 , 41 ], power spectrum analysis [ 42 ], or entropic analysis [ 38 ], the same type of result was obtained, which confirms component identification as a valid tool to identify functional deficits.…”

Section: Introductionmentioning

confidence: 99%

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Exploratory Study on Chemosensory Event-Related Potentials in Long COVID-19 and Mild Cognitive Impairment: A Common Pathway?

et al. 2023

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People affected by the Long COVID-19 (LC) syndrome often show clinical manifestations that are similar to those observed in patients with mild cognitive impairments (MCI), such as olfactory dysfunction (OD), brain fog, and cognitive and attentional diseases. This study aimed to investigate the chemosensory-evoked related potentials (CSERP) in LC and MCI to understand if there is a common pathway for the similarity of symptoms associated with these disorders. Eighteen LC patients (mean age 53; s.d. = 7), 12 patients diagnosed with MCI (mean age 67; s.d. = 6), and 10 healthy control subjects (mean age 66; s.d. = 5, 7) were recruited for this exploratory study. All of them performed a chemosensory event-related potentials (CSERP) task with the administration of trigeminal stimulations (e.g., the odorants cinnamaldehyde and eucalyptus). Study results highlighted that MCI and LC showed reduced N1 amplitude, particularly in the left frontoparietal network, involved in working memory and attentional deficits, and a reduction of P3 latency in LC. This study lays the foundations for evaluating aspects of LC as a process that could trigger long-term functional alterations, and CSERPs could be considered valid biomarkers for assessing the progress of OD and an indicator of other impairments (e.g., attentional and cognitive impairments), as they occur in MCI.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Exploratory Study on Chemosensory Event-Related Potentials in Long COVID-19 and Mild Cognitive Impairment: A Common Pathway?

et al. 2023

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“…The difference between OERP and CSERP is to distinguish the pure olfactory perception from olfactory perception with trigeminal nerve stimulation. OERP therefore uses pure odorants (2-phenylethyl alcohol, vanillin), while CSERP uses stimuli that can stimulate the trigeminal nerve (carbon dioxide, pheromones) [ 41 ]. Regardless of the type of stimulants used, both methods allow detection of changes in brain wave frequencies.…”

Section: Investigations For Olfactory Disordersmentioning

confidence: 99%

Investigations and Outcomes for Olfactory Disorders

Luke

Lee

Jegatheeswaran

et al. 2022

Curr Otorhinolaryngol Rep

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Purpose of Review To provide a detailed overview of the investigations and core outcome measures for olfactory disorders. Recent Findings Olfactory disorders can have a detrimental impact to the quality of life of patients. There are a wide range of causes of olfactory loss including sinonasal conditions, idiopathic, post-head trauma or infection. This review highlights the key investigations and reasoning for their use to clinically assess and research patients with olfactory disorders. In addition, this review outlines the core outcome measures for olfaction that will help inform future research in olfactory disorders. Summary A systematic approach with history taking and examination particularly with nasal endoscopy can determine the cause of the olfactory disorder in most cases. Specific olfactory disorder questionnaires can demonstrate the impact on quality of life, while psychophysical testing can objectively assess and monitor olfaction over time. Olfactory-evoked potentials and functional MRI are reserved for research, whereas CT and MRI imaging are used depending on history and examination. A core outcome set for olfaction has been developed that will help standardise the outcome measures used in olfaction and olfactory disorders research.

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“…Finally, “Chemosensory Event-Related Potentials and Power Spectrum Could Be a Possible Biomarker in 3M Syndrome Infants?” by Invitto and colleagues [ 6 ] analyzed the cortical olfactory response through chemosensory event-related potentials and power spectra calculated by electroencephalogram signals recorded in infants with 3M syndrome, a rare autosomal recessive dwarf syndrome. The results suggest that a diagnostic evaluation of the cortical olfactory response at an early age may provide indications for subsequent genetic screening.…”

mentioning

confidence: 99%