Chemosensory function assessed with psychophysical testing and event-related potentials in patients with atrophic rhinitis

Huart, Caroline; Eloy, Philippe; Collet, Stéphanie; Rombaux, Philippe

doi:10.1007/s00405-011-1670-3

Cited by 21 publications

(7 citation statements)

References 28 publications

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“…Evidence about reduced trigeminal sensitivity in ENS patients can be also found in a study by Huart et al, where in a smaller cohort of patients the authors reported that six out of nine had no trigeminal responses when assessed with event related potentials …”

Section: Discussionmentioning

confidence: 93%

Intranasal trigeminal function in patients with empty nose syndrome

et al. 2017

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Section: Discussionmentioning

confidence: 93%

Intranasal trigeminal function in patients with empty nose syndrome

et al. 2017

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“…Only a single study 21 to date has measured olfaction in ATR (N = 75), and that too was by a nonvalidated technique based on 4 colorless liquid odors, wherein 10% revealed normal olfaction while 90% showed abnormality—of which 30% had mild loss, 24% severe dysfunction, and 36% complete anosmia. A single study 22 on secondary ATR based on validated olfactory tests revealed dysfunction in 7 of 9 patients who underwent total bilateral inferior turbinectomy.…”

Section: Discussionmentioning

confidence: 99%

Olfaction in Primary Atrophic Rhinitis and Effect of Treatment

Mishra¹,

Shukla²,

Verma³

et al. 2020

OTO Open

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Objective To assess olfactory and clinical morbidity in primary (idiopathic)–type atrophic rhinitis and its course following treatment. Study Design Prospective nonrandomized controlled cohort study with follow-up. Setting Department of Otorhinolaryngology and Head and Neck Surgery of a university hospital (tertiary heath care center). Methods Sixty-one patients with atrophic rhinitis underwent assessment of clinical severity with baseline olfaction with the Brief Smell Identification test, while the improvement of their status following surgical versus nonsurgical treatment was further assessed. Results Olfaction was universally deranged with bimodal age presentation and female predominance (61%). Clinical improvement was significantly associated with surgical treatment but did not reveal any relation with up-front severity of disease. A near-significant association of age with severity did not reveal significance when stratified by age group. Baseline olfaction or its change following treatment did not reveal any significance with severity of disease or clinical improvement. Radiologic atrophy also did not reveal any significant relation with severity criteria. Conclusions Olfactory functions as compared with clinical parameters provided better reflection of underlying (systemic) pathology with environmental interaction, while later it mainly signified localized condition. Accordingly, olfaction was affected early and recovered slowly (or not at all), independent of clinical morbidity, which in turn is affected rather late but recovers early. Olfactory dysfunction at the initial stage may be a surrogate marker of potential worsening clinical condition, since bacteria often superinfect underlying susceptible nasal environment. While surgery mainly improved clinical parameters without affecting olfaction directly, a true improvement would include recovery of both.

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“…Taken together, these reports strongly suggest that rhinologists should consider assessment of trigeminal function, especially in patients potentially being prone to develop paradoxical nasal obstruction after surgery, a condition commonly coined as empty nose syndrome (60,61) .…”

Section: Trpm8 Importance For Intranasal Trigeminal Functionmentioning

confidence: 92%

Rhinology in review: from COVID-19 to biologicals

Fokkens¹,

Landis²,

Hopkins³

et al. 2021

Rhin

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We look back at the end of what soon will be seen as an historic year, from COVID-19 to real-world introduction of biologicals influencing the life of our patients. This review describes the important findings in Rhinology over the past year. A large body of evidence now demonstrates loss of sense of smell to be one of the most common symptoms of COVID-19 infection; a meta-analysis of 3563 patients found the mean prevalence of self-reported loss to be 47%. A number of studies have now shown long-term reduced loss of smell and parosmia. Given the high numbers of people affected by COVID-19, even with the best reported recovery rates, a significant number worldwide will be left with severe olfactory dysfunction. The most prevalent causes for olfactory dysfunction, besides COVID-19 and upper respiratory tract infections in general, are trauma and CRSwNP. For these CRSwNP patients a bright future seems to be starting with the development of treatment with biologics. This year the Nobel prize in Medicine 2021 was awarded jointly to David Julius and Ardem Patapoutian for their discoveries of receptors for temperature and touch which has greatly enhanced our understanding of nasal hyperreactivity and understanding of intranasal trigeminal function. Finally, a new definition of chronic rhinitis has been proposed in the last year and we have seen many papers emphasizing the importance of endotyping patients in chronic rhinitis and rhinosinusitis in order to optimise treatment effect.

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Chemosensory function assessed with psychophysical testing and event-related potentials in patients with atrophic rhinitis

Cited by 21 publications

References 28 publications

Intranasal trigeminal function in patients with empty nose syndrome

Intranasal trigeminal function in patients with empty nose syndrome

Olfaction in Primary Atrophic Rhinitis and Effect of Treatment

Rhinology in review: from COVID-19 to biologicals

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