Chemosensory sensilla of the Drosophila wing express a candidate ionotropic pheromone receptor

He, Zhe; Luo, Yichen; Shang, Xueying; Sun, Jennifer S; Carlson, John R.

doi:10.1371/journal.pbio.2006619

Cited by 51 publications

(41 citation statements)

References 83 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Baseline sleep was also increased when Ir52a-GAL4 and Ir76b-GAL4 neurons were simultaneously silenced in the absence of wing cut. A recent study has shown that hydrophobic molecules can be transferred from one fly to the wing margin of another to influence male and female sexual behavior via Ir52a (34). These data support a role for Ir52a in sleep regulation given the interaction between sleep and sexual behavior (21).…”

Section: Specific Wing Chemosensory Neurons Mediate Wing Cut-induced mentioning

confidence: 65%

Disrupting flight increases sleep and identifies a novel sleep-promoting pathway in Drosophila

2020

View full text Add to dashboard Cite

Sleep is plastic and is influenced by ecological factors and environmental changes. The mechanisms underlying sleep plasticity are not well understood. We show that manipulations that impair flight in Drosophila increase sleep as a form of sleep plasticity. We disrupted flight by blocking the wing-expansion program, genetically disrupting flight, and by mechanical wing perturbations. We defined a new sleep regulatory circuit starting with specific wing sensory neurons, their target projection neurons in the ventral nerve cord, and the neurons they connect to in the central brain. In addition, we identified a critical neuropeptide (burs) and its receptor (rickets) that link wing expansion and sleep. Disrupting flight activates these sleep-promoting projection neurons, as indicated by increased cytosolic calcium levels, and stably increases the number of synapses in their axonal projections. These data reveal an unexpected role for flight in regulating sleep and provide new insight into how sensory processing controls sleep need.

show abstract

Section: Specific Wing Chemosensory Neurons Mediate Wing Cut-induced mentioning

confidence: 65%

Disrupting flight increases sleep and identifies a novel sleep-promoting pathway in Drosophila

2020

View full text Add to dashboard Cite

show abstract

“…Insects have evolved a complex peripheral taste system and possess taste sensory neurons in multiple organs including the legs, wings, and labellum (the distal segment of the proboscis) (Scott, 2018). These external taste neurons enable insects to rapidly sample different substrates as they navigate an environment, and insects use taste cues to guide ongoing behaviors including feeding as well as locomotion, egg-laying, grooming, and courtship (Corfas et al, 2019;He et al, 2019;Joseph and Heberlein, 2012;Thistle et al, 2012;Thoma et al, 2016;Yanagawa et al, 2014). Thus the presence of ON and OFF responses to tastants may be important for the generation of behavior in insects.…”

Section: Introductionmentioning

confidence: 99%

Individual bitter-sensing neurons inDrosophilaexhibit both ON and OFF responses that influence synaptic plasticity

Devineni

Deere

Sun

2020

Preprint

View full text Add to dashboard Cite

The brain creates internal representations that translate sensory stimuli into appropriate behavior. Most studies of sensory processing focus on which subsets of neurons are activated by a stimulus, but the temporal features of the neural response are also important for behavior. In the taste system, the timing of peripheral sensory responses has rarely been examined. We investigated the temporal properties of taste responses in Drosophila melanogaster and discovered that different types of taste sensory neurons show striking differences in their response dynamics. Strong responses to stimulus onset (ON responses) and offset (OFF responses) were observed in bitter-sensing neurons in the labellum, whereas bitter neurons in the leg and other classes of labellar taste neurons showed only an ON response. Individual bitter labellar neurons generate both the ON and OFF responses through a cell-intrinsic mechanism that requires canonical bitter receptors. The bitter ON and OFF responses at the periphery are propagated to dopaminergic neurons that innervate the mushroom body and mediate aversive learning. When bitter is used as a reinforcement cue, the bitter ON and OFF responses can drive opposing types of synaptic plasticity and the effect of the OFF response dominates, likely due to the rapid and preferential habituation of the ON response. Together, these studies characterize novel features of neural responses in the taste system and reveal their importance for neural circuit function.

show abstract

“…In insects, GRs expressed in gustatory neurons acts as taste receptors, which are responsible for feeding behaviors (Dunipace et al, 2001;Scott et al, 2001). As a large and highly divergent family of ionotropic glutamate receptors in Drosophila, IRs are subdivided into "antennal IRs, " which are expressed in antennae specifically and mainly involved in olfactory recognition; and "divergent IRs, " which are found in various tissues taking responsible for sensation of taste (Jaeger et al, 2018;Lee et al, 2018;He et al, 2019;Rimal et al, 2019). Various chemosensory associated proteins in insect play diverse functions, such as those listed in Table 1.…”

Section: Introductionmentioning

confidence: 99%

Identification of Leg Chemosensory Genes and Sensilla in the Apolygus lucorum

Zhang

et al. 2020

Front. Physiol.

View full text Add to dashboard Cite

Apolygus lucorum (Hemiptera: Miridae), one of the main insect pests, causes severe damage in cotton and many other economic crops. As is well-known, legs play important roles in the chemoreception of insects. In this study, the putative chemosensory proteins in legs of A. lucorum involved in close or contact chemical communication of adult bugs were investigated using RNA transcriptome sequencing and qPCR methods. Transcriptome data of forelegs, middle legs and hind legs of adult bugs demonstrated that 20 odorant binding protein (OBP) genes, eight chemosensory protein (CSP) genes, one odorant receptor (OR) gene, one ionotropic receptor (IR) gene and one sensory neuron membrane protein (SNMP) gene were identified in legs of A. lucorum. Compared to the previous antennae transcriptome data, five CSPs, IR21a and SNMP2a were newly identified in legs. Results of qPCR analysis indicated that all these putative chemosensory genes were ubiquitously expressed in forelegs, middle legs and hind legs of bugs. Furthermore, four types of sensilla on legs of A. lucorum including sensilla trichodea (subtypes: long straight sensilla trichodea, Str1; long curved sensilla trichodea, Str2), sensilla chaetica (subtypes: sensilla chaetica 1, Sch1; sensilla chaetica 2, Sch2; and sensilla chaetica 3, Sch3), sensilla basiconca (subtypes: mediumlong sensilla basiconca, Sba1; short sensilla basiconca, Sba2) and Böhm bristles (BB) were found using scanning electron microscopy. Additionally, the largest number of sensilla was observed on hind legs, while the forelegs had the smallest number of sensilla. Our data provide valuable insights into understanding the chemoreception of legs in A. lucorum.

show abstract

Chemosensory sensilla of the Drosophila wing express a candidate ionotropic pheromone receptor

Cited by 51 publications

References 83 publications

Disrupting flight increases sleep and identifies a novel sleep-promoting pathway in Drosophila

Disrupting flight increases sleep and identifies a novel sleep-promoting pathway in Drosophila

Individual bitter-sensing neurons inDrosophilaexhibit both ON and OFF responses that influence synaptic plasticity

Identification of Leg Chemosensory Genes and Sensilla in the Apolygus lucorum

Contact Info

Product

Resources

About