Chemosurgery with trichloroacetic acid for allergic rhinitis: Evaluation of the efficacy in terms of inhibition of Th2 cell infiltration

Yao, Kazuo; Sato, Kentaro; Usui, Daisuke; Kurihara, Rika; Okamoto, Makito; Iguchi, Yoshiaki; Nishiyama, Koichiro

doi:10.1016/j.anl.2008.08.005

Cited by 7 publications

(9 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have shown that a topical TCA injury can result in epithelial cell degeneration in the human nasal cavity. 7,10 However, the precise cellular effects were minimally investigated in these studies. Hoechst is a fluorescent dye that selectively and reliably labels DNA and nuclei organelles.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Topical Corticosteroid Pretreatment Mitigates Cellular Damage After Caustic Injury to the Nasal Upper Airway Epithelium

Huang

Velasquez

Nguyen

et al. 2019

Am J Rhinol�Allergy

View full text Add to dashboard Cite

Background Topical corticosteroids are currently employed to reduce established airway inflammation; their prophylactic use might help limit cellular damage against harmful stimuli. Objectives To determine the effects of a prophylactic topical application of budesonide (BD) on an in vivo nasal epithelium injury model induced by trichloroacetic acid (TCA). Methods C57Bl/6 mice were exposed to intranasal TCA topical application. Three groups received topical intranasal BD, saline solution, or no intervention prior to a single topical exposure to TCA. Controls were not exposed to TCA. Whole nasal cavity coronal sections were analyzed at 1, 3, and 6 days postinjury at tissue and cellular levels using histopathological analysis, immunofluorescent staining, and fresh tissue RNA microarray analysis. Results Prophylactic topical corticosteroid exposure protected the nasal epithelium from acute damage, maintaining epithelial thickness and cell survival. Six days following TCA exposure, epithelial and cellular changes were less pronounced on the BD-treated group compared to all exposure groups. The microarray analysis was used to evaluate the gene transcripts in all treatment groups. Ciliary tip protein, Sentan, and submucosal protein S100b were identified as potential factors in epithelial airway protection; immunofluorescent staining corroborated their presence and location within the respiratory epithelium. Conclusion Topical corticosteroid treatment to the nasal epithelium can mitigate several of the early deleterious effects of acute epithelial damage in experimental airway injuries caused by TCA. These findings suggest a novel, direct cytoprotective effect of corticosteroids on the nasal epithelium, and the potential of expanding the use of prophylactic periprocedural topical corticosteroids for respiratory epithelial tissues.

show abstract

Section: Discussionmentioning

confidence: 99%

“…6 Nasal TCA application has been reported as a "chemosurgery" treatment for patients with rhinitis through chemical cautery of the epithelium and subepithelium with associated protein degeneration. [7][8][9][10] Using our TCA nasal injury model, we determined the benefits of the corticosteroid pretreatment on preventing epithelial and cellular damage.…”

mentioning

confidence: 99%

Topical Corticosteroid Pretreatment Mitigates Cellular Damage After Caustic Injury to the Nasal Upper Airway Epithelium

Huang

Velasquez

Nguyen

et al. 2019

Am J Rhinol�Allergy

View full text Add to dashboard Cite

show abstract

“…Nasal provocation testing reveals a significant decrease in posttreatment responses. [6] Yao et al [7] observed improvement of other symptoms of AR, such as rhinorrhea and sneezing, after topical TCA application, and also demonstrated that TCA causes reduction in mucosal infiltration of T cells (Th2 type), which is responsible for symptoms of AR. This suggests that migration of these cells was inhibited by the local action of the acid.…”

Section: Discussionmentioning

confidence: 99%

“…This suggests that migration of these cells was inhibited by the local action of the acid. [7] Nasal obstruction can be evaluated by subjective and objective methods. Objective assessment is by acoustic rhinometry and rhinomanometry.…”

Section: Discussionmentioning

confidence: 99%

Clinical efficacy of combined treatment with trichloroacetic acid chemical cautery and steroid spray in allergic rhinitis with inferior turbinate hypertrophy

Nemade¹

2018

Tr-ENT

View full text Add to dashboard Cite

Objectives: Comparison between efficacy of combined treatment with trichloroacetic acid (TCA) chemical cautery and steroid nasal spray in the treatment of allergic rhinitis (AR) with inferior turbinate hypertrophy (ITH). Patients and Methods: A total of 132 patients with ITH due to AR were included in the study. Forty-four patients each were treated with TCA chemical cauterization of inferior turbinate (Group A), steroid nasal spray (Group B), or combined treatment with TCA cautery and steroid nasal spray (Group C). The Symptom Severity Grade (SSG) 1-5 based on a validated Questionnaire Sheet (QS) as well as Visual Analog Scale were documented before and after treatment. Results: Before treatment, the SSG was 3-5 in 37 (84%), 36 (81.8%), and 40 (90.9%) patients in groups A, B, and C, respectively. At six months post-treatment, SSG 1-2 was achieved in 20 patients (45.4%) in Group A, 18 patients (40.9%) in group B and 31 patients (70.4%) in Group C. Statistically significant improvement was found in patients who received the combined treatment. Conclusion: Combined treatment with TCA chemical cauterization of inferior turbinate and steroid nasal spray can be effective therapy for amelioration of symptoms of AR and ITH.

show abstract

“…Histologic examination of the treated nasal mucosa showed gradual recovery of its normal function within 1 to 3 years after application without any serious side effects 41,47 . Initially blocked immunological function of the ciliated nasal epithelium was also found gradually recovering 45,48‐55 …”

mentioning

confidence: 92%

COVID ‐19: Topical agents and therapeutic prevention of nasal viral acquisition

Abdelhadi

Ruszczak

Schwartz

2020

Dermatologic Therapy

View full text Add to dashboard Cite

Since the spread of SARS‐CoV‐2 became a pandemic, the number of cases has been continuously growing worldwide. Numerous recommendations and suggestions have been published to prevent the acquisition and spread of the SARS‐CoV‐2, especially to protect health workers and front‐line caregivers. SARS‐CoV‐2 is transmitted by aerosol, rendering air defense with suitable ventilation and adequate mask use pivotal. Recently, locally applied antiseptic, antiviral, or structure competitive receptor blockers were suggested to attack the virus at its main point of invasion, the nasal mucosa and nasopharynx. We discuss the most plausible and safe ideas to reduce viral load at the point of entry, and subsequently the spread of SARS‐CoV‐2 to the lower respiratory tract, lungs, and other organs. In addition, we analyze the value and recommend clinical trials employing topical trichloroacetic acid (TCA), a substance well known from dermatologic and cosmetic procedures. It has been proven to successfully block the nasal entry for airborne allergens, preventing the development of allergic rhinitis and asthma, and to be curative for early stages of viral infections entering through the oral mucosa. For SARS‐CoV‐2, TCA in a single, short‐time application is expected to remodel the nasal and nasopharyngeal epithelia, eliminating both the receptors and cells responsible for viral entry and subsequent viral spread to the lower respiratory tract. Moreover, this may have therapeutic benefits for those recently infected by reducing local viral replication. Such procedures are cheap, safe, and can be conducted in almost every setting, especially in regions with inadequate financial and logistic resources.

show abstract

Chemosurgery with trichloroacetic acid for allergic rhinitis: Evaluation of the efficacy in terms of inhibition of Th2 cell infiltration

Cited by 7 publications

References 28 publications

Topical Corticosteroid Pretreatment Mitigates Cellular Damage After Caustic Injury to the Nasal Upper Airway Epithelium

Topical Corticosteroid Pretreatment Mitigates Cellular Damage After Caustic Injury to the Nasal Upper Airway Epithelium

Clinical efficacy of combined treatment with trichloroacetic acid chemical cautery and steroid spray in allergic rhinitis with inferior turbinate hypertrophy

COVID ‐19: Topical agents and therapeutic prevention of nasal viral acquisition

Contact Info

Product

Resources

About