Chemotactic cytokine receptor 5 gene polymorphism: Relevance to microvascular complications in type 2 diabetes

Buraczyńska, Monika; Żukowski, Paweł; Waciński, Piotr; Berger-Smyka, Beata; Drăgan, M; Mozul, Slawomir

doi:10.1016/j.cyto.2012.01.007

Cited by 17 publications

(23 citation statements)

References 26 publications

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“…Pro-inflammatory, Th1, Th2, and Th17 cytokines, as well as transforming growth factor-beta (TGF-β) have been reported to take part in the development and progression of diabetic nephropathy [46]. In this regard, gene polymorphism of cytokines and their receptors may exhibit functional variations, the delineation of which may be useful to predict the susceptibility and progression of diabetic nephropathy [48]. Certainly, improved knowledge of recognizing cytokines as significant pathogenic mediators in diabetic nephropathy would open new avenues for development of novel potential therapeutic agents in the future.…”

Section: Inflammatory Cytokines As Biomarkers In Diabetic Nephropathymentioning

confidence: 99%

Review and discussion of tubular biomarkers in the diagnosis and management of diabetic nephropathy

Tramonti

Kanwar

2012

Endocrine

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The prevalence of diabetic nephropathy has tremendously increased with the relentless rise in the incidence of diabetes over the last couple decades. Diabetic nephropathy is a leading cause of morbidity and mortality, and it invariably leads to an end stage renal disease (ERSD). In an effort to delay the onset of ESRD systematic screening and appropriate management are needed to evaluate the progression of renal damage in diabetic nephropathy. The reliability of current tests in predicting the onset, progression and response to various regimens for diabetic nephropathy is still under debate; and it has engendered a search for more sensitive and specific urinary biomarkers, especially those reflective of tubular dysfunctions. It is well known that there is a good correlation between the degree of damage to the tubulo-interstitial compartment and the deterioration of renal functions. In view of this, the utility of urinary biomarkers, reflective of tubular injury, reported in the literature is discussed in this brief review.

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Section: Inflammatory Cytokines As Biomarkers In Diabetic Nephropathymentioning

confidence: 99%

Review and discussion of tubular biomarkers in the diagnosis and management of diabetic nephropathy

Tramonti

Kanwar

2012

Endocrine

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“…In clinical studies, CCR5 gene polymorphisms are not only related to the phenotypes [75, 76] but also to the risk of nephropathy in type 1 and type 2 diabetes patients [82–86]. During diabetic nephropathy, the production of chemokines, such as RANTES, CCL3, and CCL4, by glomerular and tubular cells has been reported in hyperglycemia [87–89].…”

Section: Introductionmentioning

confidence: 99%

Emerging role of chemokine CC motif ligand 4 related mechanisms in diabetes mellitus and cardiovascular disease: friends or foes?

Chang¹,

Chen

2016

Cardiovasc Diabetol

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Chemokines are critical components in pathology. The roles of chemokine CC motif ligand 4 (CCL4) and its receptor are associated with diabetes mellitus (DM) and atherosclerosis cardiovascular diseases. However, due to the complexity of these diseases, the specific effects of CCL4 remain unclear, although recent reports have suggested that multiple pathways are related to CCL4. In this review, we provide an overview of the role and potential mechanisms of CCL4 and one of its major receptors, fifth CC chemokine receptor (CCR5), in DM and cardiovascular diseases. CCL4-related mechanisms, including CCL4 and CCR5, might provide potential therapeutic targets in DM and/or atherosclerosis cardiovascular diseases.

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“…This polymorphism leads to a premature stop codon, and thus results in a shortened non-functional protein that fails to reach the cell surface (Khademi et al, 2008). The 59029 G/A polymorphism of the CCR5 gene, which is detected in the promoter region, causes increased transcriptional activity of the gene, thus increasing the protein level (Buraczynska et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Effects of genetic variants of CCR5 chemokine receptors on oral squamous cell carcinoma

Tanyel¹,

Çinçin²,

Röhlig³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. We aimed to evaluate the effect of genetic variants of the chemokine C-C motif receptor (CCR5) in the pathogenesis of oral squamous cell carcinoma (OSCC). A total of 127 patients diagnosed with OSCC and 104 healthy individuals were included in the study. The polymorphisms CCR5 59029 and CCR5-delta32 were assessed with the polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP) method from peripheral blood samples of both groups. There was a statistically significant difference between the control and patient groups for CCR5 59029 A/G genotypes (P < 0.01). Individuals carrying the CCR5 59029 G allele (GG +AG genotypes) had a 2.84-fold increased risk for OSCC (P < 0.0001), and the CCR5 59029 AA genotype frequency was higher in the control group than in the patient group (P < 0.0001). The CCR5-delta 32 genotype frequencies did not differ significantly between controls and cases (P > 0.05). CCR5 59029 GG and CCR5- CCR5 gene in oral carcinoma delta32 DD + ID genotype frequencies were significantly increased in Grade II-III OSCC patients compared with Grade I-II OSCC patients. In conclusion, these results suggested that the G allele of the CCR5 59029 polymorphism might be a risk factor due to the loss of receptor function that might cause increased inflammation leading to the development of OSCC.

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Chemotactic cytokine receptor 5 gene polymorphism: Relevance to microvascular complications in type 2 diabetes

Cited by 17 publications

References 26 publications

Review and discussion of tubular biomarkers in the diagnosis and management of diabetic nephropathy

Review and discussion of tubular biomarkers in the diagnosis and management of diabetic nephropathy

Emerging role of chemokine CC motif ligand 4 related mechanisms in diabetes mellitus and cardiovascular disease: friends or foes?

Effects of genetic variants of CCR5 chemokine receptors on oral squamous cell carcinoma

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