Chemotactic defects in severe combined immunodeficiency

Pahwa, Savita; Smithwick, Elizabeth M.; Grimes, Elena; O’Reilly, Richard J.; Pahwa, Rajendra; Good, Robert A.

doi:10.1016/s0022-3476(78)80068-7

Cited by 16 publications

(2 citation statements)

References 23 publications

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“…Phenotypic Analysis of Lymphocytes. T and B lymphocytes and T-cell subsets were quantified in whole blood using monoclonal antibodies (mAbs) (Ortho-immune, Coulter clone, and Becton Dickinson reagents) by flow cytometry (22).…”

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confidence: 99%

Recombinant interleukin 2 therapy in severe combined immunodeficiency disease.

Pahwa

Chatila

Pahwa

et al. 1989

Proc. Natl. Acad. Sci. U.S.A.

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Severe combined immunodeficiency disease (SCID) is a congenital disorder of severe B-and T-lymphocyte dysfunction in which several pathogenic mechanisms have been identified. The present study describes a female child with SCID who had a primary defect in the ability of T cells to secrete interleukin 2 (IL-2). B-and T-cell numbers were normal, but their functions were severely deficient. Mitogen and antigen-driven lymphoproliferative responses were diminished but were correctable in vitro with recombinant IL-2

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mentioning

confidence: 99%

Recombinant interleukin 2 therapy in severe combined immunodeficiency disease.

Pahwa

Chatila

Pahwa

et al. 1989

Proc. Natl. Acad. Sci. U.S.A.

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“…Persistent abnormal leucotactic movement has been observed in several patients affected by primary immunodeficiencies (4,9,16,23). The incidence of this association remains unknown, since the routine immunological study in most of the immunodeficient patients does not include leucotactic studies.…”

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confidence: 99%

Neutrophil Chemotactic Defect and Hypogammaglobulinemia

Lorente¹,

Fontán²,

Rodrı́guez³

et al. 1980

Acta Paediatrica

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A 15-months-old boy developed agranulocytosis after administration of Chloramphenicol and Aminopyrine. In spite of total hematological recovery, the patient's immunological study disclosed a persistent neutrophil chemotactic defect and hypogammaglobulinemia. Other studies of specific and non-specific immunity were normal. Neutrophil adherence, random and random stimulated mobility were always within the normal range. The presence of chemotactic inhibitors was discarded. In vitro incubation of his neutrophils with Cytochalasin B at 0.1 micrograms/ml final concentration, reversed the chemotactic abnormality suggesting a possible cell membrane defect.

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