Chemotactic Effect of Hormones in Mouse Spermatozoa

Acrosome reaction in the cumulus oophorus revisited: involvement of a novel sperm-released factor NYD-SP8

“…Although the attractants and the molecular mechanism of sperm chemotaxis in mammals are not yet known, sperm chemotaxis to follicular fluid, the mature oocyte and the surrounding cumulus oophorus have been reported by a number of studies (Jeon et al, 2001;Wang et al, 2001;Sun et al, 2005;Gil et al, 2008;Guidobaldi et al, 2008;Oren-Benaroya et al, 2008). It has been postulated that the chemoattractants, including heparin, progesterone, atrial natriuretic peptide (ANP), adrenaline, oxytocin, calcitonin and acetylcholine, might also be originated from the cumulus oophorus (Sliwa, 1993;Sliwa, 1994;Anderson et al, 1995;Sliwa, 1995;VillanuevaDíaz et al, 1995).…”

Chemotaction of Mouse Spermatozoa Induced by Certain Hormones

“…So far, it is not clear which of the substances affect the behavior of spermatozoa. Their chemotactic migration was induced in vitro by various natural substances, e.g., follicular fluid as a whole [I 1, 331 or heparin [30, 311 and certain hormones, oxytocin and noradrenalin [32], which are included in the follicular fluid. As suggested, the changes in spermatozoan motility and migration were created by adequate activation of the cell receptors.…”

“…So far, it is not clear which of the chemical substances present in the follicular fluid are chemoattractant for the sperm cells. A chemotactic effect was noted in vitro with reference to heparin [30, 3 11 and certain hormones [32], substances present under natural conditions in normal follicular fluid. A number of hormones are present in the follicular or oviduct fluid [9, 25, 281, and very little is known about their role in the fertilization process (e.g.…”

Hyaluronic Acid and Chemoattractant Substance From Follicular Fluid: In Vitro Effect of Human Sperm Migration

“…The chemotactic behavior of mammalian spermatozoa is not self-evident. In vitro studies of this process have been reported in rabbit [4], bull [11], man [1,18,22], and mouse [20,21]. This process in mammals has been investigated in response of spermatozoa to gradients of synthetic peptides [11], follicular fluid [2,8,15,25], and some substances presented in the follicular fluid, e.g., heparin [18,19] and hormones [14,[20][21][22].…”