Chemotherapeutic toxicity—the relationship between patientsʼ pretreatment expectations and post-treatment results

Cassileth, Barrie R.; Lusk, Edward J.; Bodenheimer, Brenda J.; Farber, John M.; Jochimsen, Peter R.; Morrin-taylor, Bonnie

doi:10.1097/00000421-198510000-00015

Cited by 69 publications

(59 citation statements)

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“…The fatigue prevalence rate of 76% is consistent with results of our initial survey [6] and previous studies that assessed the prevalence of fatigue in patients with cancer [1,5,12,14,15,[18][19][20][21]. The high prevalence of fatigue in cancer patients may be due in part to the evolution of more intensive treatment strategies, including combined modality approaches and high-dose chemotherapy [17].…”

Section: Discussionsupporting

confidence: 87%

Impact of Cancer-Related Fatigue on the Lives of Patients: New Findings From the Fatigue Coalition

et al. 2000

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Purpose. This survey was designed to confirm the prevalence and duration of fatigue in the cancer population and to assess its physical, mental, social, and economic impacts on the lives of patients and caregivers.Patients and Methods. A 25-minute telephone interview was completed with 379 cancer patients having a prior history of chemotherapy. Patients were recruited from a sample of 6,125 households in the United States identified as having a member with cancer. The median patient age was 62 years, and 79% of respondents were women. Patients reporting fatigue at least a few times a month were asked a series of questions to better describe their fatigue and its impact on quality of life.Results. Seventy-six percent of patients experienced fatigue at least a few days each month during their most recent chemotherapy; 30% experienced fatigue on a daily basis. Ninety-one percent of those who experienced fatigue reported that it prevented a "normal" life, and 88% indicated that fatigue caused an alteration in their daily routine. Fatigue made it more difficult to participate in social activities and perform typical cognitive tasks. Of the 177 patients who were employed, 75% changed their employment status as a result of fatigue. Furthermore, 65% of patients indicated that their fatigue resulted in their caregivers taking at least one day (mean, 4.5 days) off work in a typical month. Physicians were the health care professionals most commonly consulted (79%) to discuss fatigue. Bed rest/ relaxation was the most common treatment recommendation (37%); 40% of patients were not offered any recommendations.Conclusions. Cancer-related fatigue is common among cancer patients who have received chemotherapy and results in substantial adverse physical, psychosocial, and economic consequences for both patients and caregivers. Given the impact of fatigue, treatment options should be routinely considered in the care of patients with cancer.

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Section: Discussionsupporting

confidence: 87%

Impact of Cancer-Related Fatigue on the Lives of Patients: New Findings From the Fatigue Coalition

et al. 2000

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“…At this moment we can only speculate about possible beneficial interventions. Results have indicated that patients do no always expect fatigue to be a side-effect of treatment (Cassileth et al, 1985;Love et al, 1989;Tierney et al, 1991). Preparatory information on what to expect in terms of fatigue during and after treatment, could enhance the ability of patients to cope with this symptom.…”

Section: Discussionmentioning

confidence: 99%

“…Chemotherapy also results in a high incidence of fatigue. Prevalence rates between 75% and 100% of tiredness during chemotherapy have been reported (Linssen et al, 1979;Nerenz et al, 1982;Cassileth et al, 1985;de Haes et al, 1987;Nail & King, 1987;Love et al, 1989). Finally, feelings of tiredness are characteristic for the period of convalescence after surgery (Christensen et al, 1982).…”

mentioning

confidence: 99%

Fatigue in cancer patients

Smets

Garssen²,

Schuster-Uitterhoeve³

et al. 1993

Br J Cancer

272

139

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(Cristensen, 1989).To date there are few studies which systematically register how many cancer patients experience fatigue, in which stage of the disease process and to what extent. To give an indication, a literature-search using MEDLINE with CD-ROM over the period 1980 to 1991 yielded nine references in which 'fatigue' was included in the title and 'cancer' was included in title, keyword or abstract. Eight of these references pertained to nursing research.An appraisal of the research literature concerning fatigue in cancer is presented in this paper to give an overview of what is currently known. Literature, other than obtained using the MEDLINE-procedure, was gathered either by searching for studies in which fatigue was assessed as part of patient functioning or through references of the papers obtained. This procedure does evidently not lead to an exhaustive list of all the studies which included fatigue as an outcome-variable. However, we think to have obtained a representative sample. Topics that will be discussed are: the conceptualisation of fatigue and its measurement, prevalence rates of fatigue during and after treatment and somatic and psychological correlates of fatigue. Finally, considerations with regard to research and interventions will be discussed.

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“…Furthermore, CRF often continues even when the survivor's cancer is undetectable or in remission [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][23][24][25]. Survivors with varying cancer diagnoses and receiving different types of treatment report a frequency of CRF in the range of 60%-100%, with 41% or more indicating severe CRF (a score >7 on an 11-point Likert scale where 0 = no CRF and 10 = CRF as bad as you can imagine) during treatment [3][4][5]16,26,27]. Moreover, as many as 81% of survivors report persistent CRF, with 17%-38% indicating persistent severe CRF 6 months or longer after completing treatment [11,[27][28][29][30][31].…”

Section: Introductionmentioning

confidence: 99%

Integrative Nonpharmacologic Behavioral Interventions for the Management of Cancer-Related Fatigue

et al. 2007

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Chemotherapeutic toxicity—the relationship between patientsʼ pretreatment expectations and post-treatment results

Cited by 69 publications

References 0 publications

Impact of Cancer-Related Fatigue on the Lives of Patients: New Findings From the Fatigue Coalition

Impact of Cancer-Related Fatigue on the Lives of Patients: New Findings From the Fatigue Coalition

Fatigue in cancer patients

Integrative Nonpharmacologic Behavioral Interventions for the Management of Cancer-Related Fatigue

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