Pharmacotherapy is an essential component of dental practice to manage pain, prevent infections, and maintain oral health. Analgesics such as non steroidal anti-inflammatory drugs (NSAIDs) and opioids are commonly used to manage pain during and after dental procedures. Antibiotics are prescribed to treat and prevent infections, but their use should be limited to reduce the risk of antibiotic resistance. Local anesthetics provide safe and effective pain relief during dental procedures. Fluorides are used to prevent tooth decay and strengthen tooth enamel. Dental healthcare providers should evaluate each patient's individual needs and medical history to determine the most appropriate pharmacotherapy. Patient education on the proper use of medications and potential side effects is also important. By incorporating pharmacotherapy as part of a comprehensive dental care plan, patients can experience a more comfortable and successful dental experience.