Chemotherapy and cognition: comprehensive review on doxorubicin-induced chemobrain

El-Agamy, Sara Emad; Abdel-Aziz, Amal Kamal; Esmat, Ahmed; Azab, Samar S.

doi:10.1007/s00280-019-03827-0

Cited by 74 publications

(48 citation statements)

References 118 publications

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“…[5d,e, 12] The relatively nontoxic decomposition products of 1 may fight the neurological and cognitive disorders that commonly occur from cancer itself, or standard chemotherapy. [24] Future studies will be directed towards: i) tuning the reactivity and hydrophobicity of mixed-ligand V V complexes in aqueous media and in cell membrane models; [11] ii) testing the activity of V V complexes under the hypoxic conditions of solid tumors [25] that favor the formation of V IV and V III intermediates; [26] and iii) developing suitable stabilized formulations for intratumoral injections. [1]…”

Section: Angewandte Chemiementioning

confidence: 99%

A Short‐Lived but Highly Cytotoxic Vanadium(V) Complex as a Potential Drug Lead for Brain Cancer Treatment by Intratumoral Injections

et al. 2020

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The chemistry and short lifetimes of metal‐based anti‐cancer drugs can be turned into an advantage for direct injections into tumors, which then allow the use of highly cytotoxic drugs. The release of their less toxic decomposition products into the blood will lead to decreased toxicity and can even have beneficial effects. We present a ternary VV complex, 1 ([VOL1L2], where L1 is N‐(salicylideneaminato)‐N′‐(2‐hydroxyethyl)ethane‐1,2‐diamine and L2 is 3,5‐di‐tert‐butylcatechol), which enters cells intact to induce high cytotoxicity in a range of human cancer cells, including T98g (glioma multiforme), while its decomposition products in cell culture medium were ≈8‐fold less toxic. 1 was 12‐fold more toxic than cisplatin in T98g cells and 6‐fold more toxic in T98g cells than in a non‐cancer human cell line, HFF‐1. Its high toxicity in T98g cells was retained in the presence of physiological concentrations of the two main metal‐binding serum proteins, albumin and transferrin. These properties favor further development of 1 for brain cancer treatment by intratumoral injections.

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Section: Angewandte Chemiementioning

confidence: 99%

A Short‐Lived but Highly Cytotoxic Vanadium(V) Complex as a Potential Drug Lead for Brain Cancer Treatment by Intratumoral Injections

et al. 2020

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“…Doxorubicin can affect some key memory-related kinase systems. For instance, doxorubicin can activate p38 MAPK and extracellular signal-regulated kinase (ERK), two kinases that have opposite roles: while the former mediates synaptic inhibition, the latter promotes synaptic facilitation ( 40 ).…”

Section: Direct Neurotoxicitymentioning

confidence: 99%

Doxorubicin-Induced Cognitive Impairment: The Mechanistic Insights

Zhang

et al. 2021

Front. Oncol.

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Chemotherapy can significantly prolong the survival of patients with breast cancer; Nevertheless, the majority of patients receiving chemotherapy such as doxorubicin may have cognitive deficits that manifest as impairments in learning, reasoning, attention, and memory. The phenomenon of chemotherapy-induced cognitive decline is termed as chemotherapy-related cognitive impairment (CRCI) or chemo-brain. Doxorubicin (DOX), a commonly used drug in adjuvant chemotherapy for patients with breast cancer, has been reported to induce chemo-brain through a variety of mechanisms including DNA damage, oxidative stress, inflammation, dysregulation of apoptosis and autophagy, changes in neurotransmitter levels, mitochondrial dysfunction, glial cell interactions, neurogenesis inhibition, and epigenetic factors. These mechanisms do not operate independently but are inter-related, coordinately contributing to the development of chemo-brain. Here we review the relationships of these mechanisms and pathways in attempt to provide mechanistic insights into the doxorubicin-induced cognitive impairment.

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“…43 Moreover, more than 50% of patients on or following chemotherapy develop symptoms similar to those described above for long-COVID syndrome (Table 1), especially cognitive dysfunction, 44-47 a condition that has been termed "chemofog" 48,49 or "chemobrain," 50-54 and has been associated with distinct neuroimaging findings. 55,56 A number of drugs have been implicated in "chemobrain" (Table 2) most notably doxorubicin, [57][58][59] methotrexate, 60,61 lenalidomide, 62 rituximab, 62 and trastuzamab. 63 There have been intense efforts to understand the biochemical 64 or cellular 44,65,66 mechanisms responsible for chemobrain.…”

Section: Chemotherapymentioning

confidence: 99%

Long‐COVID syndrome‐associated brain fog and chemofog: Luteolin to the rescue

Cholevas²,

Polyzoidis³

et al. 2021

BioFactors

171

140

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COVID-19 leads to severe respiratory problems, but also to long-COVID syndrome associated primarily with cognitive dysfunction and fatigue. Long-COVID syndrome symptoms, especially brain fog, are similar to those experienced by patients undertaking or following chemotherapy for cancer (chemofog or chemobrain), as well in patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) or mast cell activation syndrome (MCAS). The pathogenesis of brain fog in these illnesses is presently unknown but may involve neuroinflammation via mast cells stimulated by pathogenic and stress stimuli to release mediators that activate microglia and lead to inflammation in the hypothalamus. These processes could be mitigated by phytosomal formulation (in olive pomace oil) of the natural flavonoid luteolin.

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Chemotherapy and cognition: comprehensive review on doxorubicin-induced chemobrain

Cited by 74 publications

References 118 publications

A Short‐Lived but Highly Cytotoxic Vanadium(V) Complex as a Potential Drug Lead for Brain Cancer Treatment by Intratumoral Injections

A Short‐Lived but Highly Cytotoxic Vanadium(V) Complex as a Potential Drug Lead for Brain Cancer Treatment by Intratumoral Injections

Doxorubicin-Induced Cognitive Impairment: The Mechanistic Insights

Long‐COVID syndrome‐associated brain fog and chemofog: Luteolin to the rescue

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