Long‐COVID syndrome‐associated brain fog and chemofog: Luteolin to the rescue

Tc, Theoharides; Cholevas, Christos; Polyzoidis, Konstantinos S.; Politis, Antonios

doi:10.1002/biof.1726

Cited by 171 publications

(176 citation statements)

References 169 publications

(236 reference statements)

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“…The holistic approach to treatment should extend to the services offered, with professionals including occupational and speech and language therapists addressing cognitive changes 190. Cognitive impairment in long covid, sometimes called “brain fog,” has been compared to “chemobrain.”191 The Mayo clinic recommendations suggest strategies to manage chemobrain including repeating exercises, tracking what influences deficits, and using stress relief and coping strategies. Furthermore, medications including methylphenidate, donepezil, modafinil, and memantine may be considered 192.…”

Section: Guidelinesmentioning

confidence: 99%

See 1 more Smart Citation

Long covid—mechanisms, risk factors, and management

Crook

Raza

Nowell

et al. 2021

BMJ

1,274

1,213

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Since its emergence in Wuhan, China, covid-19 has spread and had a profound effect on the lives and health of people around the globe. As of 4 July 2021, more than 183 million confirmed cases of covid-19 had been recorded worldwide, and 3.97 million deaths. Recent evidence has shown that a range of persistent symptoms can remain long after the acute SARS-CoV-2 infection, and this condition is now coined long covid by recognized research institutes. Studies have shown that long covid can affect the whole spectrum of people with covid-19, from those with very mild acute disease to the most severe forms. Like acute covid-19, long covid can involve multiple organs and can affect many systems including, but not limited to, the respiratory, cardiovascular, neurological, gastrointestinal, and musculoskeletal systems. The symptoms of long covid include fatigue, dyspnea, cardiac abnormalities, cognitive impairment, sleep disturbances, symptoms of post-traumatic stress disorder, muscle pain, concentration problems, and headache. This review summarizes studies of the long term effects of covid-19 in hospitalized and non-hospitalized patients and describes the persistent symptoms they endure. Risk factors for acute covid-19 and long covid and possible therapeutic options are also discussed.

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Section: Guidelinesmentioning

confidence: 99%

“…These strategies may prove useful for long covid. Specific to long covid, luteolin, a natural flavonoid, may alleviate cognitive impairment by inhibiting mast cell and microglia activation,191 but clinical trials are required.…”

Section: Guidelinesmentioning

confidence: 99%

Long covid—mechanisms, risk factors, and management

Crook

Raza

Nowell

et al. 2021

BMJ

1,274

1,213

View full text Add to dashboard Cite

show abstract

“…'Brain fog' is a colloquial term being used to describe the cognitive difficulties faced by a large group of patients following COVID-19. Neuroinflammation, resulting from the pathogenic and stress stimuli, is the proposed mechanism for this condition, though concrete evidence is yet to be seen [17].…”

Section: Discussionmentioning

confidence: 99%

Persistent Symptoms in Post-COVID-19 Patients Attending Follow-Up OPD at Sukraraj Tropical and Infectious Disease Hospital (STIDH), Kathmandu, Nepal

et al. 2021

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The long-term effects of COVID-19 among survivors is a matter of concern. This research aimed to study persistent symptoms in post-COVID-19 patients attending a follow-up clinic at a tertiary care hospital in Nepal. All patients, presenting to the outpatient clinic during the study duration of six weeks, with history of positive reverse transcriptase- polymerase chain reaction for severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) at least two weeks prior to presentation, were included. The duration of follow-up ranged from 15 till 150 days with the mean duration of 28 days after diagnosis of COVID-19. Of 118 patients, 43 (36.4%) had a history of mild COVID-19, 15 (12.8%) had moderate, and 60 (50.8%) had severe. At the time of presentation, 97 (82.2%) patients reported that they had at least one persistent/new symptom beyond two weeks from the diagnosis of COVID-19. Dyspnea, fatigue, chest heaviness, and cough were the commonest persistent complaints in 48 (40.7%), 39 (33.1%), 33 (28%), and 32 (27.1%) patients, respectively. The findings in our study highlight the need for extended monitoring of post-COVID-19 patients following discharge, in order to understand and mitigate long-term implications of the disease.

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“…Hydrogel or cream enriched with HT has been proposed as an antiviral hand cream [26]. On another hand, it has been proposed that phytosomal formulation containing luteolin (in olive pomace oil) may mitigate some of the symptoms observed in long-COVID patients [28].…”

Section: Exploitation and Alternative Use Of Olive Oil Byproductsmentioning

confidence: 99%

Health benefits of olive oil and by-products and possible innovative applications for industrial processes

Centrone

Ranieri

Mise

et al. 2021

FFHD

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In the last few years, the production of olive oil has incredibly increased due to its beneficial properties on human health. On the other hand, the amount of waste and by-products derived from the olive oil industry has increased as well, prompting the development of new fields of research aiming to reduce disposal costs and valorize bioactive compounds from the viewpoint of the green economy. Interestingly, olive oil and by-products contain numerous molecules, including phenols, exhibiting pleiotropic effects in both in vitro and in vivo studies. This review aims to describe the more recent studies focusing to identify and describe the potential roles and the new applications of extracts isolated from wastes and by-products or specific compounds, such as hydroxytyrosol (HT) and oleuropein. Extracts or bioactive molecules from olive oil and by-products have been proposed as a food additive, to produce biofuel, for animal feeding, and to create new matrices in bioremediation protocols. Moreover, bio-compounds have been described to have numerous beneficial effects on human health as they reduce the risk of developing certain chronic diseases. Despite the already published studies, more research is necessary to valorize bioactive compounds in olive oil and by-products, as well as their potential use to improve human health and green applications in different industrial processes. Keywords: extra virgin olive oil, by-products, olive leaf extract, bioactive compounds, human health, and industrial application

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Long‐COVID syndrome‐associated brain fog and chemofog: Luteolin to the rescue

Cited by 171 publications

References 169 publications

Long covid—mechanisms, risk factors, and management

Long covid—mechanisms, risk factors, and management

Persistent Symptoms in Post-COVID-19 Patients Attending Follow-Up OPD at Sukraraj Tropical and Infectious Disease Hospital (STIDH), Kathmandu, Nepal

Health benefits of olive oil and by-products and possible innovative applications for industrial processes

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