Chemotherapy Effects on Hepatoblastoma

Saxena, Romit; Salisbury, Jonathan R.; Davenport, Mark; Howard, E.R.; Mowat, A P; Mieli‐Vergani, G.; Leake, J; Malone, M; Pritchard, Jon; Spitz, Lewis; Shafford, E. A.

doi:10.1097/00000478-199312000-00008

Cited by 66 publications

(37 citation statements)

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“…The increased survival of low birth weight infants and their increased risk of hepatoblastoma may account for the increased incidence of hepatoblastoma seen in the SEER data. the left, with bilobar involvement seen in 20%-30%, and multicentric involvement in 15% [14,15]. Less common symptoms are anorexia, weight loss, and pain [15].…”

Section: Epidemiologymentioning

confidence: 99%

“…Less common symptoms are anorexia, weight loss, and pain [15]. Association with precocious puberty has been reported [14].…”

Section: Epidemiologymentioning

confidence: 99%

“…7). In one study, osteoid made up a small component of 36% of untreated hepatoblastoma, but was increased in treated hepatoblastoma to 82% and composed up to 90% of the tumor area [14]. The presence of mesenchymal elements has been associated with improved prognosis in patients with advanced disease [29].…”

Section: Pathology/molecular Biologymentioning

confidence: 99%

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Childhood Cancers: Hepatoblastoma

2000

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Hepatoblastoma is the most common primary liver tumor in children, accounting for just over 1% of pediatric cancers. The etiology is unknown, but it has been associated with Beckwith-Weidemann syndrome, familial adenomatosis polypi, and low birth weight. The primary treatment is surgical resection, however, chemotherapy plays an important role by increasing the number of tumors that are resectable. The prognosis for patients with resectable tumors is fairly good, however, the outcome for those with nonresectable or recurrent disease is poor. Texas-Houston Medical School, 1515 Holcombe Blvd., Houston, Texas 77030, USA. Telephone: 713-745-0157; Fax 713-792-0608; e-mail: cherzog@ mdanderson.org Received June 21, 2000; accepted for publication September 6, 2000. ©AlphaMed Press 1083-7159/2000 INTRODUCTIONHepatoblastoma is the most common malignant tumor of the liver in children. Surgery remains the primary means of curative therapy, but the role of chemotherapy in both the adjuvant and neoadjuvant setting has become increasingly important over the past three decades. New insight has also been gained into the molecular biology of hepatoblastoma.

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Section: Epidemiologymentioning

confidence: 99%

“…Less common symptoms are anorexia, weight loss, and pain [15]. Association with precocious puberty has been reported [14].…”

Section: Epidemiologymentioning

confidence: 99%

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Childhood Cancers: Hepatoblastoma

2000

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“…Again, thorough examination of the biopsy or resection specimen should show other patterns of differentiation in hepatoblastoma. Another point to note is that the tumors may "differentiate" after chemotherapy (125).…”

Section: Hepatocellular Tumors In Childrenmentioning

confidence: 99%

Liver Pathology: Cirrhosis, Hepatitis, and Primary Liver Tumors. Update and Diagnostic Problems

Ferrell

2000

Modern Pathology

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“…This tumor is composed of epithelial and mesenchymal elements, the latter being represented by spindle cells, cartilage, and bone. Osteoid formation is particularly prominent after chemotherapy (12). The epithelial elements consist of a hepatocytic component that recapitulates the various stages of hepatocyte development, from the primitive blastema to embryonal hepatocytes to fetal hepatocytes.…”

mentioning

confidence: 99%