Chemotherapy for advanced ovarian cancer

Markers of Oxidative Stress and Inflammation in Ascites and Plasma in Patients with Platinum‐Sensitive, Platinum‐Resistant, and Platinum‐Refractory Epithelial Ovarian Cancer

“…It is approved by the European Medicines Agency as a treatment for the first recurrence of platinum-sensitive EOC and for the management of various solid tumors in combination with cytotoxic chemotherapy [ 18 ]. Women who present with progression despite the platinum are considered platinum-refractory and present with the worst prognosis [ 19 ].…”

Effect of TRA-8 Anti-Death Receptor 5 Antibody in Combination With Chemotherapy in an Ex Vivo Human Ovarian Cancer Model

“…It has been suggested that a combination of taxane platinum-based chemotherapy regimens administered intravenously or intraperitoneally provides the best survival outcomes. 2 Despite this aggressive treatment program, most patients will develop chemoresistance and cancer recurrence within a few years of initial diagnosis. Multiple chemotherapeutic agents have been used in an attempt to treat patients with recurrence, but response rates are generally low (10%Y20%).…”

Intravenous Versus Oral Dexamethasone Premedication in Preventing Paclitaxel Infusion Hypersensitivity Reactions in Gynecological Malignancies

“…15Y25 We assumed that docetaxel 26 and nab-paclitaxel were equivalent to paclitaxel in efficacy 27Y29 and that treatment with combination chemotherapy (platinum and taxane) had a mortality odds ratio of 0.91 (95% confidence interval [CI], 0.79Y1.05) compared to singleagent platinum. 30 The model was programmed using TreeAge Pro 2009 (TreeAge Software, Williamston, MA). For the base case, we assumed that patients were compliant with their medications as prescribed.…”