Chemotherapy for breast cancer during pregnancy

Mathelin, Carole; Annane, Kadour; Liégeois, Philippe; Bergerat, Jean‐Pierre; Dufour, Patrick

doi:10.1016/j.ejogrb.2005.05.012

Cited by 11 publications

(1 citation statement)

References 4 publications

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“…Estrogens regulate the expression of the p53 tumor suppressor protein and influence the balance between proliferation and surveillance [10], and p53 plays an important role as a tumor suppressor in Ewing's sarcoma [11]. Additionally, Estrogens receptor and the thyroid hormone receptor are known to activate transcription of the MDM2 gene [12], and both genetic and biochemical studies have shown that the MDM2 oncogene is a key negative regulator of the p53 protein [13]. It is well known that hormones, such as estrogens, thyroid hormone progestin and lots of other hormonal change greatly during pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Primary Ewing's Sarcoma/Primitive Neuroectodermal Tumor of Kidney with Caval Involvement in a Pregnant Woman

Ding

Huang²,

Ding³

et al. 2016

Urol Int

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In this article, we report the case of a woman in whom was found an abdominal mass during pregnancy and who underwent nephrectomy and extraction of the emboli after delivery. The kidney had a volume of 15 × 10 × 8 cm and pathological diagnosis was primary Ewing's sarcoma. The patient was treated with conventional chemotherapy for 1 year after surgery, at which time multiple metastases were found. From this case, we surmise that hormonal changes that occur during pregnancy may accelerate the growth of Ewing's sarcoma of the kidney, suggesting that renal tumors in pregnant women demand serious attention and that anti-cancer treatment should begin as soon as possible.

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