Chemotherapy for primary retroperitoneal yolk sac tumor: Report of a case

Hong, Waun Ki; Bhutani, Rakesh; Gerzof, Stephen G.; Doos, Wilhelm G.

doi:10.1002/1097-0142(19810101)47:1<19::aid-cncr2820470104>3.0.co;2-g

Cited by 14 publications

(7 citation statements)

References 12 publications

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“…However, extragonadal EST continues to be rare with only 40 cases reported by 1981. 9 Our series, therefore, is unique in that five of the six patients had their tumor in extragonadal sites. Occurrence of EST on the face in two of our patients is even more unusual.…”

Section: Discussionmentioning

confidence: 93%

“…Because of] this, regimens used in adults to treat ovarian carcinoma or seminoma such as modified VAC] with or without cis-platinum, vinblastine, bleomycin, and Adriamycin have been used for EST. 9,17,18 The number of patients treated with these regimens is too small to allow conclusions but the early results are encouraging. Our results parallel those reported in the literature.…”

Section: Discussionmentioning

confidence: 99%

“…The germinal origin of this tumor was later confirmed 2 and the name yolk sac carcinoma was suggested because the tumor resembled the yolk sac in early embryogenesis. In addition to the gonads, EST was reported to arise from a variety of extragonadal midline organs such as vulva, 3 vagina, 4 prostate, 5 sacrococcygeal region, 6,7 suprasellar region, 8 retroperitoneum, 9 pineal body, 10 and mediastinum. 11,12 Because of the rarity of these tumors and the multiplicity of their sites, it has not been possible to develop a uniform approach for their treatment.…”

Section: Introductionmentioning

confidence: 99%

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Yolk SAC (Endodermal Sinus) Tumor in Children: A Report of Six Cases

et al. 1984

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The purpose of this study is to describe the clinical features and results of treatment in children with gonadal and extragonadal yolk sac (endodermal sinus) tumors seen at the King Faisal Specialist Hospital and Research Centre between 1975 and 1982. Six children (five girls and one boy) with an age range of 2 to 12 years (median 4 years) are analyzed. The sites of origin included vagina (two cases), face (two cases), mediastinum (one case) and ovary (one case). One child had complete surgical excision of her ovarian tumor at the time of diagnosis. In the remaining five children, the tumor was unresectable and surgery was limited to a biopsy only. All five patients who were tested had elevated alpha-fetoprotein at diagnosis. All patients received combination chemotherapy plus radiation. Combination chemotherapy included vincristine and actinomycin D plus cyclophosphamide, Adriamycin, bleomycin, or cis-platinum. One patient was lost to follow-up while in remission, three patients are known to have died, and two children are disease-free 22 and 24 months after diagnosis. This study demonstrates a preponderance of the extragonadal form of endodermal sinus tumor in our practice and that it is highly malignant and often fatal in spite of therapy.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Yolk SAC (Endodermal Sinus) Tumor in Children: A Report of Six Cases

et al. 1984

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“…In select patients, chemotherapy alone can serve as an effective treatment. A similar case presented by Hong et al detailed the use of BEP therapy to successfully treat a primary retroperitoneal YST in an adult male patient [ 8 ]. This strategy has also been reportedly successful in the management of similar presentations in children.…”

Section: Discussionmentioning

confidence: 99%

Management of a Primary Retroperitoneal Yolk Sac Tumor

et al. 2021

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Patient: Male, 31-year-old Final Diagnosis: Primary retroperitoneal yolk sac tumor Symptoms: Lower abdominal pain Medication:— Clinical Procedure: — Specialty: Oncology • Surgery Objective: Rare disease Background: Existing literature has detailed occurrences of retroperitoneal yolk sac tumors (YSTs) as the result of metastasis from a primary gonadal site. However, primary retroperitoneal YSTs are extremely rare, thus remaining a challenge to diagnose and treat. We present a complex case of a large primary retroperitoneal YST in a man treated with neoadjuvant chemotherapy followed by surgical resection. Case Report: A 31-year-old man presented with a chief symptom of severe lower abdominal pain. Diagnostic imaging revealed a large, rapidly progressing neoplasm in the retroperitoneal region, initially thought to be a sarcoma. However, the pathological results from further biopsies found the mass to be a retroperitoneal YST, which was tethered to a large portion of the small bowel. A testicular ultrasound was used to confirm that the mass was a primary tumor with no origins in the gonads. The tumor progressed to involve several fistulas connected to the small intestine and anterior abdominal wall. The patient was treated with 3 cycles of bleomycin, etoposide, and cisplatin, followed by surgical excision of the residual mass. The patient retained normal gastrointestinal functions, and subsequent imaging revealed no evidence of recurrence 2.5 years following resection. Conclusions: Owing to the rarity of extragonadal primary YSTs, diagnostic and treatment standards have not yet been sufficiently explored. Our case demonstrates that a combination of chemotherapy and surgical resection should be considered for select patients with primary YST in the retroperitoneal region.

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“…Included in these 50 patients were 2 patients with yolk sac tumors, both of whom achieved complete remission. Based on this success, Hong et al [14] treated a 29-year-old male with a yolk sac tumor who presented with a solid retroperitoneal mass and intravenacaval obstruction, using the combination of limited surgical resection and chemotherapy consisting of cyclophosphamide, vinblastine, actinomycin D, bleomycin, and high dose cisplatinum. After induction therapy the patient improved symptomatically.…”

Section: Discussionmentioning

confidence: 99%

Primary yolk sac (endodermal sinus) tumor of the prostate: Case report and review of the literature

Schriber¹,

Flax²,

Trudeau³

et al. 1990

The Prostate

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A primary yolk sac (endodermal sinus) tumor of the prostate is described in a 40-year-old male. This is the second documented case of a yolk sac tumor occurring in the prostate gland. Treatment included surgical removal and subsequent combination chemotherapy. Four months following diagnosis, the patient died of complications. At autopsy, no residual tumor was detected. The role of combination chemotherapy as potentially curative therapy in the treatment of extragonadal yolk sac tumors is discussed.

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Chemotherapy for primary retroperitoneal yolk sac tumor: Report of a case

Cited by 14 publications

References 12 publications

Yolk SAC (Endodermal Sinus) Tumor in Children: A Report of Six Cases

Yolk SAC (Endodermal Sinus) Tumor in Children: A Report of Six Cases

Management of a Primary Retroperitoneal Yolk Sac Tumor

Primary yolk sac (endodermal sinus) tumor of the prostate: Case report and review of the literature

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