Chemotherapy, hypothyroidism and oral dysbiosis as a novel risk factor of cardiovascular pathology development

Avagimyan, Ashot; Gvianishvili, Tamuna; Gogiashvili, L; Kakturskiy, L. V.; Sarrafzadegan, Nizal; Aznauryan, Artashes

doi:10.1016/j.cpcardiol.2021.101051

Cited by 4 publications

(3 citation statements)

References 58 publications

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“…To assess the state of the redox system in the myocardium, both the markers of lipid peroxidation (LPO) damage (MDA), and the LPO limitation reproduction indices (SOD, GR, GP) were assessed. It is well-known that glutathione is the main intracellular thiol-disulfi de redox buff er, which is a cofactor of many antioxidant enzymes [19,20]. After 2 weeks, from the start of the AC-mode of chemotherapy administration, statistically signifi cant intergroup diff erences were recorded in the rat myocardial homogenate in terms of such indicators of redox homeostasis as the malondialdehyde concentra tion, and superoxide dismutase, glutathione reductase, and glutathione peroxidase activities (one-way ANOVA, p<0.0001) (Table ).…”

Section:  Resultsmentioning

confidence: 99%

Trimetazidine as a Modifier of Chemotherapy-Induced Cardiovascular Redox-Homeostasis Disturbances

Авагимян¹,

Хешмат-Гахдарижани²,

Кактурский³

2022

Кардиология В Беларуси

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Введение. Настоящее исследование направлено на изучение прооксидантного потенциала доксорубицин-циклофосфамидного режима химиотерапии наряду с оценкой возможностей антирадикальной защиты триметазидина.Цель. Оценить прорадикальное воздействие АС-режима химиотерапии на миокард наряду с обоснованием применения триметазидина.Материалы и методы. С целью проведения настоящей экспериментальной работы 80 половозрелых инбредных крыс линии Wistar были рандомным образом разделены на четыре равные группы. Модель индуцированного СПОЛ-ассоциированного повреждения миокарда была получена при одновременном применении доксорубицина и циклофосфамида. В качестве потенциального стабилизатора редокс-гомеостаза был использован триметазидин.Результаты. Определены и оценены маркеры окислительно-восстановительного баланса. Полученные данные подтвердили эффективность применения триметазидина как модификатора СПОЛ-индуцированного повреждения сердца и сосудов развившегося на фоне АС-режима химиотерапии.Выводы: 1. АС-режим химиотерапии оказывает СПОЛ-стимулирующее и антиоксидант-лимитирующее воздействие. 2. Триметазидин обеспечивает статистически достоверную нормализацию окислительно-восстановительного гомеостаза миокарда. Introduction. Our research was determined to investigate the Adriamycin + Cyclophos- phamide (AC)-mode of chemotherapy-related disturbances of cardiovascular (CV) ho- meostasis, and possibility of trimetazidine (TMZ)-induced cardioprotection.Purpose. Assess oxidative state of myocardium during AC-mode of chemotherapy ad- ministration, and justification of trimetazidine prescription among under-treatment and post-treatment cancer patient.Materials and methods. For this study, 80 inbred Wistar rats were randomly divided into four equal experimental groups. A model of lipid peroxidation (LPO)-induced myocardial injury, was attained via doxorubicin and cyclophosphamide co-administration. Trimetazi- dine was used as a probable limiter of heart and vessels morpho-functional homeostasis aggravations.Results. The markers of redox-balance, were determined and assessed. The data obtained showed that this TMZ modified the intensification of lipid peroxidation.Conclusions: 1. AC-mode of chemotherapy has LPO-stimulating and antioxidant-limiting impact. 2. TMZ provide statistically significant and valuable normalization of redox-ho- meostasis.

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Section:  Resultsmentioning

confidence: 99%

Trimetazidine as a Modifier of Chemotherapy-Induced Cardiovascular Redox-Homeostasis Disturbances

Авагимян¹,

Хешмат-Гахдарижани²,

Кактурский³

2022

Кардиология В Беларуси

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“…E. breviscapus is currently the best natural biological medicine for the treatment of obliterative cerebrovascular diseases and the sequela of cerebral hemorrhage, with an efficiency of >95% and slight side effects. According to the World Health Organization, the number of deaths from cardiovascular diseases will increase to 23.6 million by 2030 [ 10 ]. Therefore, E. breviscapus is of great significance for recovery and secondary prevention after the first onset of cardiovascular and cerebrovascular diseases.…”

Section: Introductionmentioning

confidence: 99%

Rapid and Efficient Optimization Method for a Genetic Transformation System of Medicinal Plants Erigeron breviscapus

Zhao

Guo

et al. 2023

IJMS

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Erigeron breviscapus is an important medicinal plant with high medicinal and economic value. It is currently the best natural biological drug for the treatment of obliterative cerebrovascular disease and the sequela of cerebral hemorrhage. Therefore, to solve the contradiction between supply and demand, the study of genetic transformation of E. breviscapus is essential for targeted breeding. However, establishing an efficient genetic transformation system is a lengthy process. In this study, we established a rapid and efficient optimized protocol for genetic transformation of E. breviscapus using the hybrid orthogonal method. The effect of different concentrations of selection pressure (Hygromycin B) on callus induction and the optimal pre-culture time of 7 days were demonstrated. The optimal transformation conditions were as follows: precipitant agents MgCl2 + PEG, target tissue distance 9 cm, helium pressure 650 psi, bombardment once, plasmid DNA concentration 1.0 μg·μL−1, and chamber vacuum pressure 27 mmHg. Integration of the desired genes was verified by amplifying 1.02 kb of htp gene from the T0 transgenic line. Genetic transformation of E. breviscapus was carried out by particle bombardment under the optimized conditions, and a stable transformation efficiency of 36.7% was achieved. This method will also contribute to improving the genetic transformation rate of other medicinal plants.

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“…В настоящее время на их долю ежегодно приходится более 17,6 млн смертей. Согласно прогнозам, к 2030 г. число пациентов с ССЗ превысит 23,6 млн [1]. Одним из триумфов профилактической медицины стало выявление и последующий контроль факторов риска развития и прогрессирования атеросклероза, артериальной гипертонии и сахарного диабета.…”

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Molecular mechanisms of inflammation in the development of heart failure: A review

Buziashvili,

Asymbekova,

Tugeeva

et al. 2023

Consilium Medicum

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Cardiovascular diseases continue to be the main cause of hospital mortality and lead to great disability of the working population. Numerous clinical and experimental studies have shown that inflammation is the main factor causing the growth and progression of atherosclerosis. Despite significant progress in basic therapy aimed at both preventing the development of heart failure (HF) and treating it, the prognosis in patients after their first hospitalization remains extremely unfavorable. HF is the leading cause of morbidity and mortality worldwide. Various stimuli at different stages of HF pathophysiology trigger a cascade of proinflammatory reactions with the release of interleukins, the formation of reactive oxygen species, mitochondrial DNA damage and the induction of autophagy. Based on the presented results from experimental and clinical studies, it can be expected that a better understanding of the molecular aspects in the pathophysiology of HF will open opportunities for the development of new therapeutic monoclonal antibodies.

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Chemotherapy, hypothyroidism and oral dysbiosis as a novel risk factor of cardiovascular pathology development

Cited by 4 publications

References 58 publications

Trimetazidine as a Modifier of Chemotherapy-Induced Cardiovascular Redox-Homeostasis Disturbances

Trimetazidine as a Modifier of Chemotherapy-Induced Cardiovascular Redox-Homeostasis Disturbances

Rapid and Efficient Optimization Method for a Genetic Transformation System of Medicinal Plants Erigeron breviscapus

Molecular mechanisms of inflammation in the development of heart failure: A review

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