Chemotherapy of Pneumococcal and Other Infections

Whitby, LionelE.H.

doi:10.1016/s0140-6736(00)89787-1

Cited by 95 publications

(8 citation statements)

References 14 publications

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“…From a study of experimental pneumococcal peritonitis in mice, Whitby (12) concluded that "the capsules became swollen and crenated and eventually disappeared" as the result of sulfapyridine therapy. This conclusion was in accord with the theory of Levaditi and Vaisman (13), who suggested that sulfonamide drugs also prevented the capsulation of hemolytic streptococci.…”

Section: Discussionmentioning

confidence: 99%

Studies on the Mechanism of Recovery in Pneumococcal Pneumonia

Wood

McLeod

Irons

1946

Journal of Experimental Medicine

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Section: Discussionmentioning

confidence: 99%

Studies on the Mechanism of Recovery in Pneumococcal Pneumonia

Wood

McLeod

Irons

1946

Journal of Experimental Medicine

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“…IR spectra (KBr discs) were recorded on an FTIR plus 460 or Pye Unicam SP-1000 spectrophotometer. The 1 H and 13 C NMR spectra were recorded on a Bruker Avance (III)-400 spectrometer (400 and 100 MHz, respectively) in DMSO-d 6 using Si (CH 3 ) 4 as an internal standard at the Ain Shams University, Cairo, Egypt. Elemental analyses were obtained from the Microanalytical Data Center at Cairo University, Egypt, and were performed on Vario El III Elemental CHNS analyzer.…”

Section: Methodsmentioning

confidence: 99%

Tailored‐design Synthesis of Sulfapyrimidine Derivatives

Azzam

2018

Journal of Heterocyclic Chem

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In this paper, we report an efficient and convenient approach for the synthesis of tailored‐design target sulfapyrimidine derivatives expected to show remarkable antimicrobial activities. The approach is based on reacting arylsulfonyl guanidine with α,β‐unsaturated carbonyl compounds to afford N‐(4,6‐diarylpyrimidin‐2‐yl)arylsulfonamide or with ylidene derivatives to afford N‐(6‐aryl‐5‐cyanopyrimidin‐2‐yl)arylsulfonamide, N‐(4‐amino‐5‐cyano‐6‐(methylthio)‐pyrimidin‐2‐yl)‐arylsulfonamide, and N‐(5‐cyanopyrimidin‐2‐yl)arylsulfonamide compounds through Michael addition reaction. The structure of the newly synthesized compounds was confirmed from spectral data and elemental analysis.

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“…Among the earliest uses of the antimicrobial compound sulfanilamide was that for the treatment of pneumococcal pneumonia, although the frequency with which this option was selected was limited by the popularity of serotherapy [5 11. Since the pneumococcus did not exhibit the same extreme susceptibility to sulfanilamide as did Srreptococcus pyogenes, Whitby [88] undertook a systematic search for a related chemical compound with good in vitro activity but relatively low toxicity. According to this author, "these experiments represent the one striking success in the chemotherapy of pneumococcal infections in an assessment of no less than 64 related sulfanilamide compounds."…”

Section: Sulfanilamidementioning

confidence: 99%

“…(Whitby's approach has been the basis, in more modem times, for selection of a particular formulation of a given antimicrobial compound for further clinical testing.) This work [88] was followed only 5 weeks later in The Lancer by the study of Evans and Gaisford [89], who reported that treatment with sulfapyridine reduced the overall case-fatality rate from 27% to 8% among patients with pneumonia (including 100 with lobar pneumonia) at the Dudley Road Hospital in Birmingham, England.…”

Section: Sulfanilamidementioning

confidence: 99%

A Brief History of the Pneumococcus in Biomedical Research: A Panoply of Scientific Discovery

Watson

Musher

Jacobson

et al. 1993

Clinical Infectious Diseases

125

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Because of its prominence as a cause of disease in humans, Streptococcus pneumoniae has been the subject of intensive investigation at both the clinical level and the basic scientific level during the past century. In a number of instances, these studies have resulted in important progress toward the comprehension of basic biological principles. The areas advanced by studies of the pneumococcus include an understanding of the concept of pathogenesis of infectious disease; the development of Gram's stain for identification of bacteria in specimens from patients; the elucidation of the role of the bacterial capsule in resistance to phagocytosis by cells of the host's immune system; the demonstration that molecules other than proteins are capable of eliciting the host's humoral immune responses and later, by extension, that isolated bacterial exopolysaccharides can be used safely and effectively as vaccines in humans; the documentation of the efficacy of penicillin; the collection of conclusive evidence that DNA encodes genetic information; and the investigation of putative proteinaceous virulence factors.

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Chemotherapy of Pneumococcal and Other Infections

Cited by 95 publications

References 14 publications

Studies on the Mechanism of Recovery in Pneumococcal Pneumonia

Studies on the Mechanism of Recovery in Pneumococcal Pneumonia

Tailored‐design Synthesis of Sulfapyrimidine Derivatives

A Brief History of the Pneumococcus in Biomedical Research: A Panoply of Scientific Discovery

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