Chemotherapy of tumours transplanted intracerebrally

Rosso, R.; Donelli, M.G.; Innocenti, I. Reyers-Degli; Garattini, S.

doi:10.1016/0014-2964(67)90034-5

Cited by 15 publications

(3 citation statements)

References 2 publications

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“…1~ When the drug was given intravenously there was good uptake by the neoplastic cells in the main intracerebral tumor mass, but scant uptake by tumor cells infiltrating deeply into the surrounding brain. Rosso, et al, 6 implanted Sarcoma 180 and Ehrlich carcinoma in three different sites, intracerebral, intraperitoneal, and subcutaneous, and treated the animals with cyclophosphamide and sarcolysin. The subcutaneous and intraperitoneal tumors responded to treatment but the intracerebral tumors did not.…”

Section: Discussionmentioning

confidence: 99%

The development of an intracerebral glioma model for brain tumor chemotherapy

Wassenaar¹,

Tator²,

So³

1973

Journal of Neurosurgery

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✓ The authors describe a brain tumor model for chemotherapy studies. The tumor is an intracerebral ependymoblastoma that kills the host in a short time (median survival, 27.5 days) and yields consistent, uniform survival curves. A suspension of tumor cells is injected into the right frontal lobe of the mouse by means of a stereotaxic frame, and produces a highly invasive, almost entirely intracranial brain tumor. The use of mice permits extensive chemotherapeutic trials for brain tumors at low cost. It is felt that this model will prove to be very useful for studies of brain tumor chemotherapy.

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Section: Discussionmentioning

confidence: 99%

The development of an intracerebral glioma model for brain tumor chemotherapy

Wassenaar¹,

Tator²,

So³

1973

Journal of Neurosurgery

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“…Tire levels were sufficient to kill the animals in less than 14 days. Rosso et al (40) administered known numbers of Ehrlich carcinoma and S180 cells by the intracerebral route and reported an increasing rate of survival with decreasing cell numbers; the counts ranged from 103 to 10s cells. Earlier, Schrek (43) had followed the growth rate, latency period and percentage of takes of rat tumors, suspensions of cells being injected subcutane ously.…”

Section: Discussionmentioning

confidence: 99%

Brain Changes and Survival of Animals with Tumors Implanted in the Brain

Gershbein¹,

Benuck²,

Shurrager³

1975

Oncology

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The effects of tumor cells implanted into the brain of animals on survival rates and gross and microscopic brain changes have been ascertained. Walker carcinosarcoma 256 cell suspensions were injected at several brain sites in rats and leukemia L1210 and P388 and Ehrlich ascites tumor cells, intracerebrally into BDF₁ mice. Such neoplasms provided for rapid and rather predictable growth increments. The survival rates were dependent on the number of cells introduced, those receiving the higher counts succumbing first. The brains of the animals revealed fairly discrete space-occupying lesions and neurological symptoms became apparent only hours before death due to intracranial pressure.

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“…4. Tumor cells of non-glial origin implanted in the brain [17]. Some of these models, especially the glioma tumor growing in the rodent brain as a relatively large solitary nodule, have been useful in the development of therapeutic strategies against human malignant gliomas [2,3,6,9,10].…”

Section: Tumor Cells Of Glial Origin Implanted In Extra-mentioning

confidence: 99%

A new rat brain tumor model: Glioma disseminated via the cerebral spinal fluid pathways

et al. 1990

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A rat brain tumor model has been developed with the clinical and pathological features of dissemination via the cerebral spinal fluid (CSF) pathways. A precise number of 9L gliosarcoma cells (5 x 10(2) to 5 x 10(5)) is stereotactically injected into the CSF of the lateral ventricle. The interval until the onset of neurological symptoms and then death is reproducible and dependent upon the number of cells injected. The median survival of three groups of rats receiving 5 x 10(5) cells in three different experiments was 17, 18 and 19 days respectively. For three groups receiving 5 x 10(4) cells, the median survival was 23, 24 and 25.5 days respectively and for two groups receiving 5 x 10(3) cells the median survival was 28 and 30 days respectively. The animals developed multiple tumor implants along the CSF pathways usually resulting in hydrocephalus. This tumor model was developed to simulate dissemination via CSF pathways as seen with medulloblastoma and other primitive neuroectodermal tumors of the central nervous system. It will be used to evaluate the therapeutic efficacy of intraventricularly administered anti-neoplastic drugs against small implants and malignant cells in the CSF pathways.

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Chemotherapy of tumours transplanted intracerebrally

Cited by 15 publications

References 2 publications

The development of an intracerebral glioma model for brain tumor chemotherapy

The development of an intracerebral glioma model for brain tumor chemotherapy

Brain Changes and Survival of Animals with Tumors Implanted in the Brain

A new rat brain tumor model: Glioma disseminated via the cerebral spinal fluid pathways

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