Chemotherapy–radiotherapy association in Hodgkin's Disease, clinical stages IA, II2A: Results of a prospective clinical trial with 166 patients

Abstract

One hundred sixty-six patients with clinical stages IA, II2A Hodgkin's disease were treated between April 1972 and December 1976 with three courses of multiagent chemotherapy (methylchlorethamine, vincristine, procarbazine, prednisone) followed by mantle irradiation--excluding mediastinum for those with initial upper cervical presentation and absence of mediastinal involvement--or inverted Y radiotherapy. None had staging laparotomy. With a follow-up of 12--84 months, median 40 months, the overall survival is 93.5% and the overall relapse-free survival 89.9%. Eight patients died, three of them with evident disease. Ten patients relapsed; four are now free of disease after retreatment. With chemotherapy-radiotherapy sequence, staging laparotomy is not indicated. Results and side effects of this treatment strategy are compared with those of other treatment policies.

EBVD Combination Chemotherapy Plus Low Dose Involved Field Radiation is a Highly Effective Treatment Modality for Early Stage Hodgkin's Disease

“…Our results compare favorably with most other studies using various CT regimens, such as MOPP (6,38,39), ABVD (6,40,41), VBM (8,28,42,43), EBVP (7,44) or NOVP (45) and various doses and fields of RT. Our results compare favorably with most other studies using various CT regimens, such as MOPP (6,38,39), ABVD (6,40,41), VBM (8,28,42,43), EBVP (7,44) or NOVP (45) and various doses and fields of RT.…”

A population‐based study of the outcome for patients with first relapse of Hodgkin's lymphoma

“…The optimal salvage therapy for this patient group remains to be studied. In view of excellent results with a short course of CT + RT in early stages with unfavourable prognostic signs, also reported by others (23–25), the result favours an international trend to give all patients in early and intermediate stages a short course of CT followed by RT in order to reduce late toxicity (11, 26, 27), although opposing opinions have been expressed (28).…”

Evolution of radiation techniques in the treatment of mediastinal lymphoma: from 3D conformal radiotherapy (3DCRT) to intensity-modulated RT (IMRT) using helical tomotherapy (HT): a single-centre experience and review of the literature

“…An inverse rationale has been adopted for HL in order to achieve dose de-escalation. [6][7][8][9] The trial H15 9 decided to compare eight cycles of escalated BEACOPP, six cycles of escalated BEACOPP and eight cycles of non-escalated BEACOPP. Patients with a persistent mass on CT scan were further investigated by PET scan, followed by 30 Gy of irradiation in case of positive PET.…”