Chemotherapy with Antibacterial Dyestuffs

Browning, C. H.

doi:10.1016/b978-1-4832-2972-0.50009-7

Cited by 9 publications

(8 citation statements)

References 87 publications

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“…Mechanisms of resistance to acridine dyes have been studied most extensively in trypanosomes (3,4) and, more recently, in E. coli (7; 11, 12). In these organisms acridine resistance appears correlated with a reduced net uptake of the dye, though our recent work suggests that with E. coli this may really represent an increased ability to expel a dye that can easily enter the cell (7).…”

Section: Discussionmentioning

confidence: 99%

Proflavine binding and release by sensitive and resistant Bacillus subtilis

Barabás¹,

Mehta²,

Kushner³

1970

Can. J. Microbiol.

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1970. Proflavine binding and release by sensitive and resistant BaciNlrs sublilis. Can. J. Microbiol. 16: 973-981. Proflavine binding of a sensitive strain of Bacilllis slrbiilis and of a resistant strain derived from it was compared. Proflavine was bound very rapidly and more was bound at 0 "C than at 37 "C. Boiling increased the proflavine-binding capacity at 37 "C of sensitive but not of resistant cells. The binding capacity of sensitive and resistant cells suspended in buffer was the same; this was also true in various growth media. If cells were able to grow in the presence of proflavine their proflavine content decreased.Bound proflavine was released when cells were treated with growth media or with the salts of growth media. Sodium salts of organic acids also caused a release. This effect seemed due to thcir Na+ content, and was somewhat higher for resistant than for sensitive cells. The mechanism of proflavine resistance in B. slrblilis is probably different from that of Escllerichia coli, which is thought to depend on an energydriven release of bound proflavine.

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Section: Discussionmentioning

confidence: 99%

Proflavine binding and release by sensitive and resistant Bacillus subtilis

Barabás¹,

Mehta²,

Kushner³

1970

Can. J. Microbiol.

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“…the combination of a photosensitiser, light and in situ oxygen to generate toxic radical species in the bacterial environment [3]. The uptake of dyes and stains by bacteria has long been used in their detection and several such dyes are inherently bactericidal [4]. An early example, crystal violetŵ hich is used in the di¡erential Gram stainŵ as recently tested for the chemotherapy of MRSA [5].…”

Section: Methicillin-resistantmentioning

confidence: 99%

Photobactericidal activity of phenothiazinium dyes against methicillin-resistant strains of Staphylococcus aureus

Wainwright

1998

FEMS Microbiology Letters

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The photodynamic antibacterial properties of a closely related series of phenothiazinium dyes were tested against several pathogenic strains of Staphylococcus aureus, four of which were methicillin-resistant. Illumination of the photosensitisers at a fluence rate of 1.75 mW cm 3P generally resulted in the enhancement of antibacterial activity in liquid culture and in greater efficacy than the methicillin analogue flucloxacillin. For methylene blue, dimethyl methylene blue and new methylene blue illumination led to increases in bactericidal activity 916-fold, typically 4-fold. In addition, dimethyl methylene blue and new methylene blue were active against epidemic strains of methicillin-resistant Staphylococcus aureus at concentrations lower than that of vancomycin (v0.5 WM). z 1998 Federation of European Microbiological Societies. Published by Elsevier Science B.V.

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“…As it moves around the updraft in this manner the side closest to the updraft tilts upward and eventually the material surface tips over. The more general conceptual intertwining of the updraft and downdraft in this general manner was first presented by Browning (1964) to explain how this type of long-lived storm, which he termed a supercell, could survive for several hours. Other reported supercomputer simulations (e.g., Klemp, Wilhelmson, and Ray, 1981) have also verified thais behavior, which Browning deduced from storm radar reflectivity (Doppler radar, which provides radial wind measurements, was not available at the time).…”

Section: Evolution Of the Simulated Stormmentioning

confidence: 98%

A Study of the Evolution of a Numerically Modeled Severe Storm

Wilhelmson

Jewett

Shaw

et al. 1990

The International Journal of Supercomputing Applications

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The numerical model simulation of thunderstorms in three spatial dimensions and time is leading to improved understanding of severe storm structure and evolution. The results from one of these simulations is presented using a variety of display techniques to illustrate the water and ice structure of a severe storm, how air moves and rotates in and around the storm, and how different physical processes influence storm rotation near the ground. The visualization of the data was a team effort, and the accompanying video illustrates the value of animation in studying complex fluid flow problems and the kind of visualization tools that will be readily available to most researchers in the near future.

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Chemotherapy with Antibacterial Dyestuffs

Cited by 9 publications

References 87 publications

Proflavine binding and release by sensitive and resistant Bacillus subtilis

Proflavine binding and release by sensitive and resistant Bacillus subtilis

Photobactericidal activity of phenothiazinium dyes against methicillin-resistant strains of Staphylococcus aureus

A Study of the Evolution of a Numerically Modeled Severe Storm

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