Chemotypes of Artemisia herba-alba in Israel based on their sesquiterpene lactone and essential oil constitution

Composition and infraspecific variability of Artemisia herba-alba from southern Spain

“…Analysis of oil samples from Morocco had established the existence of at least seven chemotypes of the so-called armoise oil (Benjilali et al, 1982;Ouyahya et al, 1990;Lawrence, 1993). Other chemotypes were found in oil samples from Israel and the Sinai Desert (Segal et al, 1980;Feuerstein et al, 1986;Segal et al, 1987;Yashphe et al, 1987) and further types in oil samples from Egypt (El-Hawary et al, 1983;El-Sayed and Seida, 1990). Oil composition of this species from various areas of Algeria was used to characterize a chemotype different from those found in Morocco (Vernin and Merad, 1994;Vernin et al, 1995).…”

Antiproliferative activities of Artemisia herba-alba ethanolic extract in human colon cancer cell line (HCT116)

“…[23][24][25][26][27] Artemisia herba-alba Asso is a plant that is used extensively in folk medicine in the Mediterranean region. 1,2,[28][29][30][31][32][33] Despite reported biological, pharmacological, and toxicological activities of Artemisia herba-alba, there has been no published work on the effects of extracts or components of this plant on cancer cells. In this study we investigated, for the first time, the antioxidant and anti-colon-cancer activities of AHE Asso.…”

Quantitative HPLC analysis of sesquiterpene lactones and determination of chemotypes in Eremanthus seidelii MacLeish & Schumacher (Asteraceae)

“…[3][4][5][6][7][8][9] Some of the SL isolated from the Eremanthus genus posses important biological activities, 3,[6][7][8]10 like the antiproliferative effects on some cancer cell lines 11 and the modulation of the inflammatory process in vitro, by inhibiting the NF-κβ transcriptor factor. 12 Seasonal, [13][14][15][16] circadian [17][18][19] and populational [20][21][22][23][24] variations in the content of almost all classes of secondary metabolites, including SL, [25][26][27][28][29] were reported. The recognition of variations in secondary metabolite production can be helpful in chemotaxonomic studies, specially for the determination of qualitative and quantitative chemical markers that could be applied to establish chemotypes and as additional taxonomic characters for the definition of complex taxa.…”

“…Together, these SL can be responsible for up to 7.5% of the weight of the dry leaves (data from plant 6, population A). This remarkable predominance, taken together with the SL utility as chemotaxonomic markers 24,26,29,32,33 and biological activities 3,6-8,10-12 led us to develop the present HPLC method for their quantification. …”

“…Therefore, the difference possibly remains in a differential activity of the enzymes that cyclisation 1 to 2. These significant differences in the levels of biosynthetically related SL, taken together with the valuable property of SL as chemotaxonomic markers 24,26,29,32,33 and the fact that 1 and 2 are the main constituents from the secondary chemistry in leaves of E. seidelii, lead us to propose the following quantitative chemotypes: (i) plants in this cluster are the only ones that present 2 in higher concentrations than 1. In fact, individuals in this cluster present the highest concentrations of 2 (more than 2.7% of the dried leaf weight in the plants studied) and the lowest concentrations of 1 (below 1.7% in the plants studied).…”