Chenopodium album Linn. leaves prevent ethylene glycol-induced urolithiasis in rats

Sikarwar, Indu; Dey, Yadu Nandan; Wanjari, Manish; Sharma, Ajay; Gaidhani, Sudesh; Jadhav, Ankush

doi:10.1016/j.jep.2016.11.031

Cited by 41 publications

(26 citation statements)

References 32 publications

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“…Saponins possess antilithic properties 9 and are known to disintegrate mucoproteins that are crucial components of stone matrix. 20 Tannins and polyphenols inhibit CaOx crystal formation as well as dissolve the preformed CaOx crystals by aiding calcium complexation. 21…”

Section: Microscopy Of Caox Crystalsmentioning

confidence: 99%

Antiurolithiatic Activity of Daucus carota: An In vitro Study

Bawari¹,

Sah²,

Tewari³

2018

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Context:Urolithiasis is a polygenic disorder with complex etiology and even complicated treatment outcomes. Daucus carota is a widely cultivated crop with traditional claims for its antiurolithiatic potential. Aim: Present study was an attempt to investigate the antilithic potential of D. carota root extract (DCRE) against calcium oxalate (CaOx) urolithiasis by employing in vitro methods. Methods: Nucleation, growth and aggregation assay of CaOx crystallization were used. FT-IR analysis was used for characterizing CaOx crystals. Results: DCRE exhibited significant inhibition of nucleation, growth and aggregation of CaOx crystals. It produced a favorable morphological transformation of CaOx crystals from calcium oxalate monohydrate to calcium oxalate dihydrate. FT-IR analysis confirmed formation of calcium oxalate monohydrate crystals to be utilized for growth and aggregation assays. Conclusion: DCRE possesses significant antiurolithiatic activity against CaOx urolithiasis in vitro which could be attributed to its saponins, tannins, flavonoids and polyphenolic content.

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Section: Microscopy Of Caox Crystalsmentioning

confidence: 99%

Antiurolithiatic Activity of Daucus carota: An In vitro Study

Bawari¹,

Sah²,

Tewari³

2018

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“…Many people all over the globe suffer from this pathological condition, and there is an increasing preponderance from the twentieth century until today [1]. It is a common disorder estimated to occur in approximately 12% of the population with a recurrence rate of 70-80% in male and 47-60% in female [2]. In Nigeria, earlier reports on nephrolithiasis showed low prevalence until recent studies indicated a rising incidence of urolithiasis [3].…”

Section: Introductionmentioning

confidence: 99%

“…Surgical endoscopic stone removal and extracorporeal shock wave lithotripsy have revolutionized the treatment of urolithiasis but do not prevent the likelihood of new stone formation aside acute kidney injury as a result of shockwave [8]. Also, therapies like thiazide as diuretic and alkali citrate commonly used in preventing the recurrence of hypercalciuria and hyperoxaluria which induce calculi are less effective [2].…”

Section: Introductionmentioning

confidence: 99%

Effect of moonseed vine (Triclisia gilletii Staner) on ethane-1,2-diol-induced urolithiasis and its renotoxicity in Wistar albino rats

et al. 2020

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Background: Moonseed vine (Triclisia gilletii Staner) in the family Menispermaceae is a robust creeper of up to 10 cm diameter, of the lowland dense rain forest. In Ondo State, located in the South Western part of Nigeria, the plant which is usually called Peshe is used for the management of renal-related ailments. The present study was undertaken to explore the efficacy of Triclisia gilletii, a folkloric therapy in the management of renal-related ailment. Results: Phenols, steroids, saponins, and flavonoids are present in the TGME with a total antioxidant capacity of (30.36 ± 1.90 (mg GAE/g extract), LD 50 greater than 5000 mg/kg b.w., and in vitro anti-nucleation activity (iC 50 = 7.09 mg/mL). Calcium oxalate stone formation as a result of oxalate from ethane-1,2-diol was evident by hypocalcemia, and further electrolyte imbalance and decreased glomerular filtration rate. The enhanced oxidative milieu in hyperoxaluria was evident by increased MDA and PC and decreased enzymatic and non-enzymatic antioxidants as well as renal membrane enzymes activities. The renal histopathological study further emphasized oxalateinduced damage and the ameliorative potential of TGME. Conclusion: The abnormal biochemical, redox electrolyte, membrane integrity, and histological alterations were attenuated by TGME which affirms its usage as nephroprotectant.

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“…Saponins possess antilithic properties and are known to disintegrate mucoproteins that are crucial components of stone matrix. 31 Rutin, quercetin, hyperoside and diosmin are known as flavonoids with high antioxidant and anti-lithiatic activities. 32 nBFMU contains 7.52 ± 0.40 mg quercetin equivalents/g flavonoids and 30.32 ± 0.62 mg diosgenin equivalent saponin/g.…”

Section: Discussionmentioning

confidence: 99%

Anti-urolithiatic activities of Macrotyloma uniflorum Mediated through Multiple Pathway

Patel¹,

Acharya²

2020

IJPER

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Background: Macrotyloma uniflorum Linn. (Fabaceae) seeds are widely used for their diuretic and urolithiatic effects in India. The present study investigated the effect of n-butanol fraction of M. uniflorum (nBFMU) on kidney stone using in vitro and in vivo method. Materials and Methods: Nucleation, crystal growth, crystal aggregation and crystal dissolution assays were performed for nBFMU. Two doses of nBFMU (400 and 800 mg/kg) were studied for their diuretic activity and sodium oxalate (NaOx) (70 mg/kg, i.p) induced urolithasis in male Wistar albino rats. Determination of body and kidney weight, measurement of various biochemical parameters in biological samples and examination of histology of kidney at the end of experiment were also done. Results: nBFMU exhibited a concentration dependent inhibitory activity on nucleation and aggregation along with decreased number of crystals of calcium oxalate (CaOX) produced in metastable solutions of CaOX in the in vitro experiments. Co-administration of nBFMU with NaOX has significantly (p<0.001) increased the urine volume and the level of calculus inhibitors like magnesium, citrate and decreased the level of calculus promoters like oxalate, calcium, urea and uric acid. nBFMU supplement also prevented the pathological changes in kidney and increased the glomerulus activity of the kidney. Conclusion: These results indicate that nBFMU showed significant activity in urolithiasis which might be due to its diuretic, CaOX crystal formation inhibitory effects and its ability to increase the levels of inhibitors and decrease the level of promoters of urolithiasis.

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Chenopodium album Linn. leaves prevent ethylene glycol-induced urolithiasis in rats

Cited by 41 publications

References 32 publications

Antiurolithiatic Activity of Daucus carota: An In vitro Study

Antiurolithiatic Activity of Daucus carota: An In vitro Study

Effect of moonseed vine (Triclisia gilletii Staner) on ethane-1,2-diol-induced urolithiasis and its renotoxicity in Wistar albino rats

Anti-urolithiatic activities of Macrotyloma uniflorum Mediated through Multiple Pathway

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