Cherubism: A Case Report

Abstract

Cherubism is a benign, self-limiting fibro-osseous lesion characterized by bilateral symmetric painless expansion of jaw which is more prominent in mandible than in maxilla. Males are commonly affected (2:1) and with greater severity. It becomes noticeable in early childhood and gradually regresses after puberty. Although cherubism is considered as a familial/inherited disease but many sporadic cases have been reported in literature with no familial history. Osteoblastic and osteoclastic remodeling replaces normal bone by excessive amount of fibrovascular tissue containing multinucleated giant cells. Here, we present a case report of cherubism in a 10 year old boy describing the clinical, histological, biochemical and radiographic features.

Cherubism: Cone-Beam Computed Tomography Findings in Two Siblings

“…Known to be a benign, infrequent condition with autosomal dominant inheritance, it is one of the very rare human osteoclastic lesions that is dictated by genetics. The disorder has been referred to by several names, such as bilateral giant cell tumor, familial multilocular disease, and hereditary or familial fibrous dysplasia [ 2 ].…”