2014
DOI: 10.1155/2014/291841
|View full text |Cite
|
Sign up to set email alerts
|

Chest Radiographs for Pediatric TB Diagnosis: Interrater Agreement and Utility

Abstract: The chest radiograph (CXR) is considered a key diagnostic tool for pediatric tuberculosis (TB) in clinical management and endpoint determination in TB vaccine trials. We set out to compare interrater agreement for TB diagnosis in western Kenya. A pediatric pulmonologist and radiologist (experts), a medical officer (M.O), and four clinical officers (C.Os) with basic training in pediatric CXR reading blindly assessed CXRs of infants who were TB suspects in a cohort study. C.Os had access to clinical findings for… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

4
20
0

Year Published

2015
2015
2023
2023

Publication Types

Select...
8
1

Relationship

0
9

Authors

Journals

citations
Cited by 27 publications
(24 citation statements)
references
References 14 publications
4
20
0
Order By: Relevance
“…Interestingly, modification of SPE with NH 2 -rGO/TNCC shows a significant increase of peak current with the peakto-peak separation (ΔEp) about 274 mV. This phenomenon indicates the excellent conductivity properties of NH 2 -rGO/TNCC due to the accomplishment of diffusional control by Fe(CN) 6 3−/4− ion on the surface of the electrode [49]. These results were further confirmed by the EIS measurements according to equivalent circuit Randle's model, which was found to accurately fit the experimental data as shown in Figure 3(b).…”
Section: Ftir Characterizationmentioning
confidence: 90%
See 1 more Smart Citation
“…Interestingly, modification of SPE with NH 2 -rGO/TNCC shows a significant increase of peak current with the peakto-peak separation (ΔEp) about 274 mV. This phenomenon indicates the excellent conductivity properties of NH 2 -rGO/TNCC due to the accomplishment of diffusional control by Fe(CN) 6 3−/4− ion on the surface of the electrode [49]. These results were further confirmed by the EIS measurements according to equivalent circuit Randle's model, which was found to accurately fit the experimental data as shown in Figure 3(b).…”
Section: Ftir Characterizationmentioning
confidence: 90%
“…For instance, tuberculin skin test [4] and acid-fast staining [5] are the most commonly used techniques. Meanwhile, chest radiograph [6], polymerase chain reaction (PCR) assay, Xpert MTB/RIF [7], and immunological tests [8] are the best options to shorten the diagnosis time to a few hours compared to conventional techniques which required several days. However, majority of the conventional diagnostic techniques have their limitations such as labour intensiveness, complex working protocol, and costly reagents [9].…”
Section: Introductionmentioning
confidence: 99%
“…Certain definitions were left unchanged due to a lack of interim evidence for modification. Given the recognized limitations of chest radiography for the diagnosis of tuberculosis in children and often poor interobserver agreement [27][28][29], a multistep process is still recommended that includes assessment of chest radiograph quality and independent assessment of radiologic lesion and location by at least 2 separate readers who are blinded to clinical information. There is a need to evaluate potential improved imaging techniques for the diagnosis of intrathoracic tuberculosis in children [30,31].…”
Section: Table 3 Revised Details and Definitions For Research Evaluamentioning
confidence: 99%
“…10 CXR while useful for diagnosing intrathoracic TB, is limited by poor inter-rater agreement. 11,12 Refinement of NIH definitions to be sensitive to early disease might warrant consideration. An ability to classify disease in these children would be helpful for earlier treatment with better treatment outcomes, and may be more applicable to patients followed closely on clinical trials.…”
Section: Discussionmentioning
confidence: 99%