Chetomin induces apoptosis in human triple-negative breast cancer cells by promoting calcium overload and mitochondrial dysfunction

Dewangan, Jayant; Srivastava, Sonal; Mishra, Sakshi; Pandey, Prabhash Kumar; Divakar, Aman; Rath, Srikanta Kumar

doi:10.1016/j.bbrc.2017.11.199

Cited by 28 publications

(18 citation statements)

References 28 publications

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“…For chaetomin, its sperm motility-inhibiting effect may be explained in terms of mitochondrial toxicity. Chaetomin is known to induce cell apoptosis by disrupting the mitochondrial function and by promoting calcium overload [46]. For chaetoglobosin, its sperm motility-inhibiting effect and cytostatic effect could be very likely explained by its glucose transport-inhibiting activity [23,33].…”

Section: Discussionmentioning

confidence: 99%

Detection of Chaetomium globosum, Ch. cochliodes and Ch. rectangulare during the Diversity Tracking of Mycotoxin-Producing Chaetomium-like Isolates Obtained in Buildings in Finland

Salo

Kedves

Mikkola

et al. 2020

Toxins

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The diversity of Chaetomium-like isolates in buildings in Finland is poorly documented. This paper describes a set of methods for rapid diversity tracking of 42 indoor Chaetomium-like isolates. These isolates were categorized based on their fluorescence emission, ascomatal hair morphology, responses in three bioassays and resistance/sensitivity to the wetting agent Genapol X-080. Thirty-nine toxigenic isolates were identified [Ch. globosum (n = 35), Ch. cochliodes (n = 2) and Ch. rectangulare (n = 2)]. These isolates were identified down to the species level by tef1α gene sequencing. The major toxic substances in the ethanol extracts of the Ch. globosum and Ch. cochliodes strains were chaetoglobosin, chaetoviridin A and C, chaetomugilin D and chaetomin, identified based on HPLC-UV and mass spectrometry data (MS and MS/MS). Ethanol extracts from pure Ch. globosum cultures exhibited a toxicological profile in the boar sperm motility inhibition assay (BSMI), sperm membrane integrity damage assay (SMID) and inhibition of cell proliferation (ICP) assay, similar to that exhibited by pure chaetoglobosin A. Overall, differences in fluorescence, morphology, toxicity profile, mycotoxin production and sensitivity to chemicals were consistent with those in tef1α sequencing results for species identification. The results indicate the presence of Ch. cochliodes and Ch. rectangulare in Finnish buildings, representing a new finding.

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Section: Discussionmentioning

confidence: 99%

Detection of Chaetomium globosum, Ch. cochliodes and Ch. rectangulare during the Diversity Tracking of Mycotoxin-Producing Chaetomium-like Isolates Obtained in Buildings in Finland

Salo

Kedves

Mikkola

et al. 2020

Toxins

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“…Due to the inhibition of HIF-1α, chetomin was ( 52 ) reported to decrease invasiveness in MDA-MB-231 triple negative breast cancer cells under hypoxic conditions [167]. More recently, 52 was also found to induce apoptosis in human triple-negative breast cancer cells by mitochondrial dysfunction, through the inhibition of PI3K/mTOR induced ER stress and promotion of calcium overload [168]. In fact, additional molecular mechanisms underlying chetomin ( 52 ) anticancer effects have been reported.…”

Section: Chemistry and Biological Properties Of Marine Diketopipermentioning

confidence: 99%

Double the Chemistry, Double the Fun: Structural Diversity and Biological Activity of Marine-Derived Diketopiperazine Dimers

et al. 2019

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While several marine natural products bearing the 2,5-diketopiperazine ring have been reported to date, the unique chemistry of dimeric frameworks appears to remain neglected. Frequently reported from marine-derived strains of fungi, many naturally occurring diketopiperazine dimers have been shown to display a wide spectrum of pharmacological properties, particularly within the field of cancer and antimicrobial therapy. While their structures illustrate the unmatched power of marine biosynthetic machinery, often exhibiting unsymmetrical connections with rare linkage frameworks, enhanced binding ability to a variety of pharmacologically relevant receptors has been also witnessed. The existence of a bifunctional linker to anchor two substrates, resulting in a higher concentration of pharmacophores in proximity to recognition sites of several receptors involved in human diseases, portrays this group of metabolites as privileged lead structures for advanced pre-clinical and clinical studies. Despite the structural novelty of various marine diketopiperazine dimers and their relevant bioactive properties in several models of disease, to our knowledge, this attractive subclass of compounds is reviewed here for the first time.

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“…24 Dewangan J et al have demonstrated that in triple-negative breast cancer, calcium overload in mitochondria can lead to the release of cytochrome c, which in turn triggers caspase-3 mediated cell death, while inhibition of calcium signaling using BAPTA-AM can reduce apoptosis, thus confirming that calcium signaling is involved in chetomin-induced cell death. 25 Other experts have confirmed that Fe(III) in cells can be further reduced to ferrous ions, which interacts with dihydroartemisinin to increase the toxicity of tumor cells. The increased accumulation of dihydroartemisinin in tumor cells, and the joint release activation mechanism of dihydroartemisinin and Fe(III), especially under the guidance of an externally applied magnetic field, have demonstrated the potential of this antitumor in vivo.…”

Section: Discussionmentioning

confidence: 99%

Identification SYT13 as a novel biomarker in lung adenocarcinoma

Zhang

Fan

Zheng

et al. 2019

J of Cellular Biochemistry

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Synaptotagmins are a class of proteins that play an important role in the secretion of neurotransmitters by synaptic vesicles. However, recent studies have shown that members of this family also have a certain function in the development of tumors. In this study, we first identified through The Cancer Genome Atlas data analyzed that a novel synaptotagmin, SYT13, was closely related to the prognosis of lung adenocarcinoma, but was not significantly correlated with the prognosis of lung squamous cell carcinoma. Then we knocked down the expression of SYT13 gene in lung adenocarcinoma cell lines A549 and H1299, and successfully induced decreased proliferation and clonality of lung adenocarcinoma cell lines, and observed cell cycle arrest and apoptosis enhancement in both cell lines. In addition, we detected the migration ability of SYT13 knockdown lung adenocarcinoma cell lines by the cell scratch test and the transwell test. Interestingly, there was a decreased migration ability of SYT13 knockdown in H1299 cells even though there was no significant difference in the migration of A549 cells. These results demonstrate that SYT13 plays an important role in the development of lung adenocarcinoma, which deepens our understanding of the mechanism of lung adenocarcinoma development and provides new possibilities for targeted therapy of lung adenocarcinoma.

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Chetomin induces apoptosis in human triple-negative breast cancer cells by promoting calcium overload and mitochondrial dysfunction

Cited by 28 publications

References 28 publications

Detection of Chaetomium globosum, Ch. cochliodes and Ch. rectangulare during the Diversity Tracking of Mycotoxin-Producing Chaetomium-like Isolates Obtained in Buildings in Finland

Detection of Chaetomium globosum, Ch. cochliodes and Ch. rectangulare during the Diversity Tracking of Mycotoxin-Producing Chaetomium-like Isolates Obtained in Buildings in Finland

Double the Chemistry, Double the Fun: Structural Diversity and Biological Activity of Marine-Derived Diketopiperazine Dimers

Identification SYT13 as a novel biomarker in lung adenocarcinoma

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