Chewing Ability and Tooth Loss: Association with Cognitive Impairment in an Elderly Population Study

Lexomboon, Duangjai; Trulsson, Mats; Wårdh, Inger; Parker, Marti G.

doi:10.1111/j.1532-5415.2012.04154.x

Cited by 167 publications

(238 citation statements)

References 31 publications

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“…Cross sectional population studies [29], have looked at the masticatory ability and oral health of an elderly population and assessed their mental state using the mini-mental state examination (MMSE) to identify those with cognitive impairment, and found that a correlation exists between the two. This pattern of investigation was common across many reports.…”

Section: Human Studies Measuresmentioning

confidence: 99%

“…The BDNF levels are thought to be higher due to reduced uptake by TrkB, as expression of this receptor is reduced. The exact cause of the reduced TrkB expression is unknown, but various hypotheses are put forward; decreased mastication with the liquid diet leads to a drop in sensory input from the trigeminal and facial nerve to the somatic sensory cortex, or decreased mastication stimulates BDNF expression, and the continuous release of BDNF results in negative feed- Table 2 Results from human studies on mastication and the effects on cognitive function Reference Population Study Outcome [29] >77 years, Swedish population Dental status and chewing difficulty and cognitive function (measured by MMSE)…”

Section: Outcome Of Rodent Studiesmentioning

confidence: 99%

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The impact of mastication on cognition: Evidence for intervention and the role of adult hippocampal neurogenesis

Smith

Miquel-Kergoat²,

Thuret

2016

NUA

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Abstract. Adult hippocampal neurogenesis (AHN) in the dentate gyrus of the hippocampus has been shown to affect mood, cognition, learning ability and memory. A growing area of interest is whether mastication or chewing also affects AHN. This article aims to collect the evidence from animal and human studies to ascertain whether mastication is an oral environment enrichment capable of having a modulatory effect on AHN and associated behaviors.Current data point toward a causal relationship between masticatory ability and cognitive function. Experimental studies on mice and rats have consistently shown that impairing masticatory function results in physical and behavioral changes. A recurring theme of decreased neural stem cells proliferation in the hippocampus was seen in most of the studies found. Human population study has shown that tooth loss and masticatory difficulty are positively correlated with having greater odds of cognitive impairment. However, no causal mechanism has yet been found to explain the effects of mastication on AHN.Further studies, especially in humans, are warranted to ascertain whether mastication could be used as a potential health intervention to slowdown cognitive decline in the aging population or delay the onset of diseases such as dementia.

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Section: Human Studies Measuresmentioning

confidence: 99%

Section: Outcome Of Rodent Studiesmentioning

confidence: 99%

The impact of mastication on cognition: Evidence for intervention and the role of adult hippocampal neurogenesis

Smith

Miquel-Kergoat²,

Thuret

2016

NUA

View full text Add to dashboard Cite

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“…In particular, in the elderly person, a decrease in the number of existing teeth due to aging causes a decline in chewing ability, which in turn leads to a decrease in nutrient intake [4] [5]. Associations between chewing ability with activities of daily living (ADL) [6], cognitive function [7], and QOL [8] [9] have also been reported.…”

Section: Introductionmentioning

confidence: 99%

Relationship among Health Related Quality of Life, Quality of Sleep, and Oral Health Condition

Sato¹,

Kurokawa²,

Sugimoto³

et al. 2018

Health

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Japan's aging rate (ratio of elderly aged 65 and older to total population) has exceeded 20%. The aim of this study was to clarify the relationships between Health Related Quality of Life (HRQOL), Body Mass Index (BMI), and sleep quality. Subjects were 51 adults over 55 years old with chronic disease who living in the community. Instruments and structured interviews were used giving due consideration to privacy. Interviews were conducted within 10 -20 minutes at the out-patient department. The evaluation instruments included body-mass index, Pittsburgh Sleep Quality Index (PSQI), HRQOL, and OHIP-14. A significant positive correlation (ρ = 0.321, p < 0.05) between PSQI and QOL (OHIP-14) scores was confirmed with sleep quality being lower with lower QOL scores. A negative correlation (ρ = −0.339, p < 0.05) between physical health component summary scores (PCS) and mental health component summary scores (MCS) of HRQOL was confirmed, demonstrating that PCS was low, and the level of MCS was high. Sleep quality was found lower among those with lower oral health-related QOL scores. Moreover, in subjects with lower MCS scores, the PCS scores were found to be higher. Accordingly, it was considered appropriate that dental treatment and care, support the maintenance of activities and sleep, and mental health promotion which are likely requisites critical for elderly persons' maintenance of independent lifestyles in their familiar community.How to cite this paper: Sato, M.,

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“…Those who have less than 19 teeth and use no denture are in high risk of falling [29] and that chewing ability is related to problems with activities of daily living (ADL) [30], recognition function [31] and over-all HRQOL [32]. Although there are several reports concerning the relationship between chewing ability and QOL relating to health [33] [34], the relationship between chewing ability and the sleep quality has scarcely been studied.…”

Section: Introductionmentioning

confidence: 99%

The Relationship among Chronic Disease, Feeling-for-Their-Age, Sleep Quality, Health-Related Quality of Life and Activities of Daily Living of Community-Dwelling Persons over 55 Years of Age

Sugimoto¹,

Tanioka²,

Yasuhara³

et al. 2018

OJPsych

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Japan's aging population rate is increasing and healthy life expectancy has decreases by 10 years shorter than average life expectancy. The aim of this study is to determine the relationship among chronic disease, sleep quality, health-related quality of life (HRQOL), and activities of daily living in people over 55 years old who live in the community. Subjects were 161 persons aged 57 to 90 years who were treated with chronic disease in the outpatient department of the A hospital. Exclusion criteria included patients with dementia, cancer and severe heart disease. The survey evaluation questionnaires included the Pittsburgh Sleep Quality Index (PSQI), HRQOL by Short-Form 8 Health Survey (SF-8), and activities of daily living. Variables associated with quality of sleep, HRQOL in univariate analysis with p < 0.05 were entered into multivariate analysis using logistic regression with a stepwise forward selection procedure to determine independent variables and their association with major causes. The logistic regression analysis was done using SPSS software and the post-hoc power of the study was estimated using G*power. The level of significance was set at p < 0.05. The risk factor of poor sleep quality was because of history of cancer [odds ratio (OR): 3.53, 95% confidence interval (CI): 1.06 -11.77], and insomnia (OR: 3.25, 95% CI: 1.55 -6.79). The risk factors of poor physical HRQOL were motor disease (OR: 2.62, 95% CI: 1.36 -5.07), respiratory disHow to cite this paper: Sugimoto, H., Tanioka, T., Yasuhara, Y., Kurokawa, A., Sato, M., Ozawa, K., Locsin, R. and Honda, S. CI: 0.15-0.59) was as "younger than actual age" and advanced the risk factor of poor sleep quality. In addition, feeling-for-their-age (OR: 0.44, 95% CI: 0.21 -0.92) resulted in reduced risk factor of poor physical HRQOL. The risk factor of poor sleep quality was due to a patient with history of cancer. The factor for good sleep quality and the good factor for physical HRQOL were indications of feeling younger than the actual age.

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Chewing Ability and Tooth Loss: Association with Cognitive Impairment in an Elderly Population Study

Cited by 167 publications

References 31 publications

The impact of mastication on cognition: Evidence for intervention and the role of adult hippocampal neurogenesis

The impact of mastication on cognition: Evidence for intervention and the role of adult hippocampal neurogenesis

Relationship among Health Related Quality of Life, Quality of Sleep, and Oral Health Condition

The Relationship among Chronic Disease, Feeling-for-Their-Age, Sleep Quality, Health-Related Quality of Life and Activities of Daily Living of Community-Dwelling Persons over 55 Years of Age

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