Chicken anemia virus and avian gyrovirus 2 as contaminants in poultry vaccines

Varela, Ana Paula Muterle; Santos, Helton Fernandes dos; Cibulski, Samuel Paulo; Scheffer, Camila Mengue; Schmidt, Candice; Lima, Francisco Esmaile Sales; Silva, Alessandra D'Avila; Esteves, Paulo Augusto; Franco, Ana Cláudia; Roehe, Paulo Michel

doi:10.1016/j.biologicals.2014.08.002

Cited by 36 publications

(21 citation statements)

References 22 publications

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“…5, 6 AGV2 infections have furthermore been identified in diverse locations, such as Italy, South Africa, The United States, Brazil and The Netherlands, suggesting a worldwide distribution. 5, 7, 8 Moreover, a study focusing on the detection of AGV2 as a contaminant of commercially available poultry vaccines identified the presence of AGV2 in 9 out of 32 live vaccines produced in Brazil, Canada and The Netherlands, 9 which may be an explanation for the widespread distribution of AGV2. Thus, exploration of the AGV2 epidemic and AGV2 infections is warranted, especially in poultry, one of its primary hosts.…”

mentioning

confidence: 99%

Avian gyrovirus 2 in poultry, China, 2015–2016

Yao

Tuo

Gao

et al. 2016

Emerging Microbes & Infections

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confidence: 99%

Avian gyrovirus 2 in poultry, China, 2015–2016

Yao

Tuo

Gao

et al. 2016

Emerging Microbes & Infections

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“…The characteristics of the critical amino acid residues in the VP1 from the new isolates in this study indicated that although almost all the strains were virulent, some had the features of low virulent or attenuated viruses. Therefore, in this study the CAV with low or attenuated virulent features were probably mixed as a contaminant in various vaccines [8], and recover their virulence in the host. Consequently, monitoring and improving the quality of vaccines may be a useful way to control the prevalence of CAV.…”

Section: Discussionmentioning

confidence: 94%

“…CAV also has dramatic financial impact in a1111111111 a1111111111 a1111111111 a1111111111 a1111111111 areas of intensive chicken farming. Vaccination is generally used to contain the spread of the virus [8]. In a recent study, a novel human gyrovirus was isolated from a skin swab and designated as human Gyrovirus (HGyV) [9].…”

Section: Introductionmentioning

confidence: 99%

Molecular epidemiology of chicken anaemia virus in sick chickens in China from 2014 to 2015

et al. 2019

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Chicken anaemia virus (CAV), a member of the genus Gyrovirus, is the etiological agent of chicken infectious anaemia. CAV infects bone marrow-derived cells, resulting in severe anaemia and immunosuppression in young chickens and a compromised immune response in older birds. We investigated the molecular epidemiology of CAV in sick chickens in China from 2014 to 2015 and showed that the CAV-positive rate was 13.30%, in which mixed infection (55.56%) was the main type of infection. We isolated and identified 15 new CAV strains using different methods including indirect immunofluorescence assay and Western Blotting. We used overlapping polymerase chain reaction to map the whole genome of the strains. Phylogenetic analyses of the obtained sequences and related sequences available in GenBank generated four distinct groups (A–D). We built phylogenetic trees using predicted viral protein (VP) sequences. Unlike CAV VP2s and VP3s that were well conserved, the diversity of VP1s indicated that the new strains were virulent. Our epidemiological study provided new insights into the prevalence of CAV in clinical settings in recent years in China.

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“…This could be explained because the conditions in broiler farms-enclosures with a high density of individuals of the same species-likely favor a faster spread of any infection by avian pathogens than in the pristine rainforest studied here. In addition, it has been shown that CAV and GyV2 are present as contaminants in some commercial poultry vaccines [41], which could explain seroprevalence values as high as 100% in some chicken flocks for CAV [37] and the widespread distribution of GyV2 [11].…”

Section: Discussionmentioning

confidence: 99%

A Novel and Divergent Gyrovirus with Unusual Genomic Features Detected in Wild Passerine Birds from a Remote Rainforest in French Guiana

Truchado

Diaz-Piqueras

Gómez-Lucı́a

et al. 2019

Viruses

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Sequence-independent amplification techniques have become important tools for virus discovery, metagenomics, and exploration of viral diversity at the global scale, especially in remote areas. Here, we describe the detection and genetic characterization of a novel gyrovirus, named GyV11, present in cloacal, oral, and blood samples from neotropical wild birds in French Guiana. The molecular epidemiology revealed the presence of GyV11 only in passerine birds from three different species at a low prevalence (0.73%). This is the first characterization and prevalence study of a gyrovirus carried out in resident wild bird populations in a remote region, and provides evidence of the fecal-oral route transmission and local circulation of the virus. The molecular phylogeny of gyroviruses reveals the existence of two distinct gyrovirus lineages in which GyV11 is phylogenetically distinct from previously reported gyroviruses. Furthermore, GyV11 is placed basal in the gyrovirus phylogeny, likely owing to its ancestral origin and marked divergence. This study also provides important insights into the ecology, epidemiology, and genomic features of gyroviruses in a remote neotropical rainforest. The pathogenesis of this virus in avian species or whether GyV11 can infect humans and/or chickens needs to be further investigated.

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Chicken anemia virus and avian gyrovirus 2 as contaminants in poultry vaccines

Cited by 36 publications

References 22 publications

Avian gyrovirus 2 in poultry, China, 2015–2016

Avian gyrovirus 2 in poultry, China, 2015–2016

Molecular epidemiology of chicken anaemia virus in sick chickens in China from 2014 to 2015

A Novel and Divergent Gyrovirus with Unusual Genomic Features Detected in Wild Passerine Birds from a Remote Rainforest in French Guiana

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