Chicken-eaters and pork-eaters have different gut microbiota and tryptophan metabolites

Abstract

This study was aimed to evaluate the differences in the composition of gut microbiota, tryptophan metabolites and short-chain fatty acids in feces between volunteers who frequently ate chicken and who frequently ate pork. Twenty male chicken-eaters and 20 male pork-eaters of 18 and 30 years old were recruited to collect feces samples for analyses of gut microbiota composition, short-chain fatty acids and tryptophan metabolites. Chicken-eaters had more diverse gut microbiota and higher abundance of Prevotella 9, Dialister, Faecalibacterium, Megamonas, and Prevotella 2. However, pork-eaters had higher relative abundance of Bacteroides, Faecalibacterium, Roseburia, Dialister, and Ruminococcus 2. In addition, chicken-eaters had high contents of skatole and indole in feces than pork-eaters, as well as higher contents of total short chain fatty acids, in particular for acetic acid, propionic acid, and branched chain fatty acids. The Spearman’s correlation analysis revealed that the abundance of Prevotella 2 and Prevotella 9 was positively correlated with levels of fecal skatole, indole and short-chain fatty acids. Thus, intake of chicken diet may increase the risk of skatole- and indole-induced diseases by altering gut microbiota.

Dietary Alaska Pollock Protein Attenuates the Experimental Colitis Induced by Dextran Sulfate Sodium via Regulation of Gut Microbiota and Its Metabolites in Mice

“…The relative fecal composition of valeric acid positively correlated with the relative fecal abundance of [Ruminococcus] (Figure S3). Other reports also have indicated that valeric acid levels positively correlated with the relative abundance of [Ruminococcus] in human studies [11,57]. To the best of our knowledge, there have been no reports on [Ruminococcus] producing valeric acid.…”

Reconsidering Meat Intake and Human Health: A Review of Current Research

“…Recent studies have demonstrated that meat consumption influences the gut microbiota composition. [72,73] A large intake of red or processed meats results in incomplete absorption of excessive heme by the small intestine, [74] enabling unabsorbed heme to reach the large intestine and interact with gut microbes. Studies have reported that dietary heme (0.9 𝜇mol g −1 diet) reduced the 𝛼-diversity of gut microbiota, [75] increased the activity of sulfatereducing bacteria, and promoted degradation of the mucin network in mice.…”

Holistic Integration of Omics Tools for Precision Nutrition in Health and Disease

“…Remarkably, yoghurt consumption was associated with reduced visceral adiposity and changes in gut microbiome (transient increases of S. thermophilus and B. lactis species) and fecal metabolome (elevated concentrations of 3-hydroxyoctanoic acid) in female twins [ 50 ]. Of note, chicken eaters had more diverse gut microbiota and higher abundances of Prevotella 2 and 9 than pork eaters, which positively correlated with fecal levels of skatole and indole [ 51 ]. Moreover, the levels of circulatory or gut metabolites were concurrently influenced by gut microbiome alterations shaped by the quality of diet consumed [ 52 ].…”