ChikDenMaZika Syndrome: the challenge of diagnosing arboviral infections in the midst of concurrent epidemics

Paniz‐Mondolfi, Alberto; Rodríguez‐Morales, Alfonso J.; Blohm, Gabriela M.; Márquez, M. Carmen; Villamil-Gómez, Wilmer E.

doi:10.1186/s12941-016-0157-x

Cited by 87 publications

(98 citation statements)

References 40 publications

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“…Considerations on the differential diagnostic approach, not only to ZIKV infection but other arboviruses, is challenging and must be based not only the type of cutaneous lesions but also on systemic signs and symptoms. In‐depth understanding of the natural history and epidemiology of arboviral infections is pivotal, as the incubation period and onset of symptoms may differ widely or overlap in some circumstances . For example, the incubation period for ZIKV, CHIKV and DENV may significantly overlap, with a time range of 5–10 days for each .…”

Section: Diagnosismentioning

confidence: 99%

“…In‐depth understanding of the natural history and epidemiology of arboviral infections is pivotal, as the incubation period and onset of symptoms may differ widely or overlap in some circumstances . For example, the incubation period for ZIKV, CHIKV and DENV may significantly overlap, with a time range of 5–10 days for each . Other commonly considered differentials include Mayaro virus, West Nile virus, human herpesviruses (particularly HHV‐6), enteroviruses, rubella and measles, among others .…”

Section: Diagnosismentioning

confidence: 99%

“…In 2014, ZIKV reached the Americas, causing great concern because of its unprecedented pathogenicity. Even though ZIKV infections are usually mild or remain clinically unapparent, cutaneous manifestations remain a hallmark of the disease as for other mosquito‐borne viruses . We review the cutaneous clinical spectrum of ZIKV infection, and describe several aspects of its interaction with human skin cells.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cutaneous features of Zika virus infection: a clinicopathological overview

et al. 2018

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Summary Zika virus (ZIKV) is an emerging mosquito‐borne flavivirus transmitted mainly by Aedes species of mosquitos. Although the infection is usually mild and self‐limiting, it is emerging as a public health challenge in tropical and subtropical countries owing to its unprecedented pathogenicity and increased risk for fetal malformations and neurological symptoms. Cutaneous manifestations as for other mosquito‐borne viruses remain a hallmark of the disease. This article provides a detailed overview on ZIKV infection, including its varied cutaneous clinical manifestations and diagnostic aspects, and also provides detailed insights into its pathogenesis in human skin.

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Section: Diagnosismentioning

confidence: 99%

Section: Diagnosismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cutaneous features of Zika virus infection: a clinicopathological overview

et al. 2018

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“…While we evaluated the cross‐reactivity of the CHIKV immunoassays with a variety of pathogens, future studies could also evaluate the cross‐reactivity of these assays with Mayaro virus (MAYV), another alphavirus sharing geographical distribution with CHIKV in Latin America (Paniz‐Mondolfi, Rodriguez‐Morales, Blohm, Marquez, & Villamil‐Gomez, ). Recently, MAYV has caused outbreaks in Venezuela, and infections/co‐infections have been detected during outbreaks of CHIKV and DENV in Haiti and Brazil, respectively (Auguste et al, ; Vieira et al., ; White et al, ).…”

Section: Discussionmentioning

confidence: 99%

Combining anti‐IgM and IgG immunoassays for comprehensive chikungunya virus diagnostic testing

Mendoza

Robinson

Dimitrova

et al. 2019

Zoonoses and Public Health

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Chikungunya virus (CHIKV) is a mosquito‐borne pathogen that causes CHIKV fever. Definitive diagnosis is crucial for patients experiencing symptoms similar to other arboviral diseases because they can vary in clinical consequences. An increasing number of patients experience long‐term rheumatic effects of CHIKV infection, but these cases may not be optimally detected by molecular assays and anti‐CHIKV IgM ELISAs (M‐ELISAs) used for confirmation and screening, respectively. The subsequent confirmatory serological test, the plaque reduction neutralization test (PRNT), is laborious and time‐consuming. In this study, we evaluated a new diagnostic algorithm in which the M‐ELISA is conducted in parallel with an anti‐CHIKV IgG ELISA (G‐ELISA) and observed that the Euroimmun M‐ELISA combined with the Euroimmun G‐ELISA or the Abcam G‐ELISA exhibited excellent sensitivity and specificity for CHIKV. The combinations demonstrated perfect and near perfect inter‐rater agreement with the PRNT, respectively, suggesting their potential to be used as alternatives to the confirmatory serological PRNT assay for CHIKV.

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“…More clinical and epidemiological information regarding OROV is urgently needed. Especially in highly vulnerable areas, such as those where other arboviruses (CHIKV, ZIKV, DENV) are circulating because vector and climate conditions are suitable for transmission 10– 13 , research on OROV deserves more incentives among institutions, so that specific laboratory tests can be designed and more knowledge on this this emerging arbovirus can be gathered properly 2, 10– 13 . Currently, differential diagnosis of these arboviruses (CHIKV, DENV, ZIKV, MAYV) poses a significant challenge 10 , especially in the scenario of co-circulation and/or syndemics with emerging and circulating arboviruses, or even in the scenario of co-infections 10– 13 .…”

Section: Discussionmentioning

confidence: 99%